Psychiatric Manifestations of Celiac Disease Include Depression, Anxiety, and Eating Disorders

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By Jefferson Adams

September 26, 2022
By Jefferson Adams • September 26, 2022

Psychiatric Manifestations of Celiac Disease Include Depression, Anxiety, and Eating Disorders

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Reviewed and edited by a celiac disease expert.

Celiac disease is associated with a higher risk of depression, anxiety, eating disorders, along with ASD and ADHD., according to a new study.

Caption: Gone. Image: CC BY-ND 2.0--Georgie_Pauwels

Celiac.com 09/26/2022 - Celiac disease is on the rise, and so are the gastrointestinal and other symptoms that go with it. A number of researchers have documented connections between various psychiatric disorders and celiac disease. However, the relationship between celiac disease, and such psychiatric disorders is not well studied or documented.

A team of researchers recently set out to provide a greater understanding of the existing evidence and theories surrounding psychiatric manifestations of celiac disease.

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The research team included Emma Clappison, Marios Hadjivassiliou, and Panagiotis Zis. They are variously affiliated with the Medical School of the University of Sheffield, Sheffield, and the Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust and University of Sheffield, Sheffield.

Their systematic review and meta-analysis appears in a special issue on gluten-related disorders, titled, Time to Move from Gut to Brain.

The team conducted a search of online medical literature search using PubMed, pulling data on rates of celiac disease and psychiatric disorders from eligible articles. They then conducted a meta analysis of odds ratios. For their review, the team found a total of 37 articles that met their eligibility parameters.

Compared with healthy controls, the team found people with celiac disease to have a significantly higher risk for autistic spectrum disorder, attention deficit hyperactivity disorder, depression, anxiety, and eating disorders. They found no significant differences for bipolar disorder or schizophrenia.

The study revealed that celiac disease is associated with a higher risk of depression, anxiety, eating disorders, along with ASD and ADHD.

The team is calling for more research into the specific biological reasons underpinning this connection, along with the potential benefits of a gluten free diet in improving these conditions.

Read more in Nutrients 2020, 12(1), 142
anxiety

celiac disease

depression

eating disorders

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psychiatric
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Posterboy 401

Posted October 7, 2022

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To All,

It might be because Celiac's are often low in in many B-Vitamins (and commonly Magnesium as well).

Here is a nice overview article that explains how B-Vitamins regulate inflammation in the body triggering Depression symptom's by their involvement in Cytokine production.

Entitled "The effects of vitamin B (aka commmonly known as B-Vitamins) on the immune/cytokine network and their involvement in depression"

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I hope this is helpful but it is not medical advice.

Posterboy by theh grace of God,

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Posterboy 401

Posted October 7, 2022

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To All,

Here is another nice article about B-Vitains role in a healthy Central Nervous System before I get too busy and forget to post it....

Entitled "B Vitamins in the (Central) nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine (Vitamin B1), pyridoxine (Vitamin B6), and cobalamin (B12)"

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Again I hope this is helful but it is not medical advice.

Posterboy,

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About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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