Reversal of Psychopathology in Adult Coeliac Disease with the Aid of Pyridoxine (vitamin B6) - Scandinavia

Welcome to Celiac.com!

You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1-M):
Get Celiac.com Updates:

Support Our Content

eNewsletter

Donate
Record is Archived
This article is now archived and is closed to further replies.
By Scott Adams

July 26, 1996
By Scott Adams • July 26, 1996

Reversal of Psychopathology in Adult Coeliac Disease with the Aid of Pyridoxine (vitamin B6) - Scandinavia

Followers 0
Reviewed and edited by a celiac disease expert.

Source: Scandinavian Journal of Gastroenterology, 18:(2):299-304, 1983 Mar.
Authors - Hallert C., Astrom J., Walan A.

Celiac.com Sponsor (A12):
Signs of mental depression are typical in adults with coeliac disease. The response to treatment was evaluated in 12 consecutive patients by means of the Minnesota Multiphasic Personality Inventory (MMPI), with surgical patients serving as controls. The coeliacs reported no change in depressive symptoms after 1 years gluten withdrawal despite evidence of improvement in the small intestine. When re-tested after 3 years, however, after 6 months of 80mg/day of oral pyridoxine (vitamin B6) therapy, they showed a fall in the score of scale 2 (depression) from 70 to 56 (p less than 0.01), which became normalized like other pretreatment abnormalities in the MMPI. Cholecycstectomy in the control subjects produced no alterations in the MMPI profile. The results indicate a causal relationship between adult coeliac disease and concomitant depressive symptoms which seems to implicate metabolic effects from pyridoxine deficiency influencing central mechanisms regulating mood.
adult

coeliac

disease

psychopathology

pyridoxine

reversal

scandinavia

vitamin
Share
https://www.celiac.com/celiac-disease/reversal-of-psychopathology-in-adult-coeliac-disease-with-the-aid-of-pyridoxine-vitamin-b6-scandinavia-r142/
Followers 0
Go to articles
User Feedback
- 2 Comments
Recommended Comments

Guest DEbra Merryweather

Posted April 1, 2008

Share this comment

very very helpful

Link to comment

Share on other sites

Guest Iris

Posted April 1, 2009

Share this comment

Dear Scott,

Thanks a million for the newsletter and for the wonderful articles that prove we are not really depressed or crazy! I am forwarding them to my friends.

Link to comment

Share on other sites

This is now closed for further comments
Get Celiac.com Updates:

Support Celiac.com:

Join eNewsletter

Donate
About Me

Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.
Celiac.com Sponsor (A17):

Celiac.com Sponsor (A17):

Celiac.com Sponsors (A17-M):
Related Articles
Depressive Symptoms in Adult Celiac Disease
Celiac.com 11/24/2002 - The following is a Medline abstract on a study conducted by Italian researchers that demonstrated a connection between celiac disease and clinical depression.
Scand J Gastroenterol 1998 Mar;33(3):247-50 Related Articles, Links
Ciacci C, Iavarone A, Mazzacca G, De Rosa A.
Dept. of Gastroenterology, University of Naples Federico II, Italy.
BACKGROUND: Psychic symptoms and depression have been reported in celiac disease (celiac disease). The aim of this study was to explore depression in a large cohort of adult celiac disease patients.
METHODS: Depressive symptoms were evaluated in 92 adult celiacs, 100 normal controls (NC), and 48 chronic persistent hepatitis (CPH) patients by means of a modified version of the Zung Self-Rating Depression Scale...

Read Full Article...

0 comments

13,746 views
Depression and Celiac Disease
Addolorato G; Stefanini gluten-free; Capristo E; Caputo F; Gasbarrini A; Gasbarrini G
Institute of Internal Medicine, Universita Cattolica del Sacro Cuore, Rome.
Hepatogastroenterology, 43(12):1513-7 1996 Nov-Dec
Celiac.com 12/18/2002 - BACKGROUND/AIMS: Psychiatric illness and psychological behavioral pathologies may be present in celiac disease and in IBD patients. In these subjects anxiety and depression could be a main cause in the reduction of the compliance to the treatment. The aim of our study was to carry out a psychometric evaluation using appropriate means to determine the level of anxiety and depression and to distinguish between state and trait forms. The correction of such disturbances would improve the quality of life and the patients compliance to treatment...

Read Full Article...

0 comments

11,727 views
Higher Suicide Rates in Celiac Disease Patients
Celiac.com 10/03/2011 - A number of studies show that people with celiac disease have higher risk of depression and death from external causes, but there are no conclusive studies on death from suicide.
A research team set out to more deeply examine the risk of suicide in people with celiac disease. The team included J. F. Ludvigsson, C. Sellgren, B. Runeson, N. Långström, and P. Lichtenstein. They are affiliated with the Department of Paediatrics at Örebro University Hospital in Sweden.
The team examined suicide risk in individuals with celiac disease where the small intestinal biopsy showed no villous atrophy.
For their study, the team collected biopsy data from all 28 clinical pathology departments in Sweden for 29,083 individuals diagnosed during 1969-2007 with ce...

Read Full Article...

7 comments

20,414 views
Higher Depression Risk in Women with Celiac Disease
Celiac.com 01/09/2012 - Women with celiac disease face a higher risk for depression than the general population, even once they have adopted a gluten-free diet, according to U.S. researchers.
A team of researchers recently used a Web-mediated survey to assess a range of physical, behavioral and emotional experiences in 177 U.S. adult women, who reported a physician-provided diagnosis of celiac disease.
The team was led by Josh Smyth, professor of biobehavioral health and medicine at Pennsylvania State University, and included members from Syracuse University and Drexel University.
The survey gathered information about how closely people follow a gluten-free diet and assessed various symptoms of celiac disease from physical symptoms to the respondents' experience ...

Read Full Article...

13 comments

17,874 views
Recent Activity
1. 1 hour ago - nanny marley replied to nanny marley's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  9
  
  New here help needed
  
  Thankyou for that information yes I totally relate to that it's a very good read and I've felt like that too to the point were going out for dinner was aniexty before I even left home and it's funny her name is jean because that was my grandma's name and I also believe she coeliac undiagnosed because I look back now and she couldn't tolerate most things...
2. 2 hours ago - Woodster991 posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  0
  
  Is it gluten?
  
  I've had ibs for years however I have noticed recently when I've had alcohol and then the usual hangover takeaway I get a whole range of symptoms. To start with Gurgling in stomach Brain fog Occasional cramps Diarrhea Severe constipation where it comes out in slithers and very dry Knot in lower right abdo side. Sensitive...
3. 7 hours ago - nanny marley replied to Mantooth's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  Anyone Else Experiencing These Symptoms?
  
  Your on the right track lactose was a good change for me too this is a great forum keep asking questions I think we both found a pot of gold here to help us 😊 x
4. 14 hours ago - trents replied to nanny marley's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  9
  
  New here help needed
  
  Ichthus is the Greek word (using English letters) for fish. The letters in the actual Greek word form an acronym that come from the first letters in the Greek words for "Jesus", "God's Son," "Savior". Now, back to your family's denial of your celiac disease, I think you can relate to this:
5. 15 hours ago - Mantooth replied to Mantooth's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  3
  
  Anyone Else Experiencing These Symptoms?
  
  Thanks for the kind words. It's hard to convince my doctor to investigate further because of a negative blood test and he only tested me for one marker. 🙃 I've come to the point where I need to take this into my own hands because the doctors are infuriating and it's not going anywhere. I've been gluten free for a week and feeling better but I was still co...