Jump to content
  • Sign Up

Clinical Significance Of Genetic Test Results?

Rate this topic

Recommended Posts

Hi everyone!

I posted here a few months ago with a host of non-specific symptoms (of which I still haven't been able to decipher if they are part of Hashimoto's, imbalanced gut flora due to a heavy dose of antibiotics this year or a crappy diet). Nothing to really jump out at me (like an irregular menstrual cycle) to say "a-ha! this is something seriously abnormal going on here!" The most annoying symptom has to be a feeling of constant sleepiness, and loose, smelly stools all the time regardless of what I am eating.

I decided to do a genetic test because I was curious, but at the same time knowing that the clinical significance would be very little due to the fact that 40% of people have a genetic predisposition. 

My gene test was positive for DQ8 and a DQX.x (X means non DBQ2/DBQ8 and x means non DQA5) - which only puts me on a *slightly* higher risk than the general population, a 1 in 89 chance opposed to a 1 in 100. From what I understand, fewer than 10% of people with celiac have DQ8 and the majority have DQ2. 

Do I need to do regular testing for celiac disease in this case? Or can I just lay low on testing in the meanwhile? My TTG-IgA test was negative in August, although I probably know I should try doing the full panel at least once.



edit: Also, isn't DQ8 associated with thyroiditis? That may explain why I have it! X_X and probably a genetic predisposition to a host of other AI diseases, too. My dad has 3 AI conditions, as of 2013.

Share this post

Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

  • Create New...