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mum2girls

What Other Tests Should I Request ?

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Apologies for all the questions.   These are the tests the Doctor ran to rule out Coeliac Dissease for my 7yo,  would these not be considered definitive?  I don't even understand the results of these ones, if anyone could explain them to me, I would greatly appreciate it.    

 

Are there other tests which could provide more information or which are more accurate?   I am seeing a gastroenterologist on Tuesday,  but as we are based in the Middle East,  I am always a bit unsure about the competencies (medical & laboratory) and experiences in this part of the world. 

 

Thank you

 

Coeliac Screen :- 

 

Endomysial Antibodies - Negative

Tissue Transglutaminase  - 0.10 u/ml (ref range 0.0 -10.0)

Immunoglobulin A - 1.35 g/L ( ref range 0.34 - 3.05)

 

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The immunoglobulin A (IgA) is considered to be a control test for celiacs.  It is a measure of the immune function in the mucosal linings of the body like the intestines and mouth.  For some reason, celiacs have a much higher tendency to be deficient in IgA - about 5% are IgA deficient whereas in the regular population it is more like 1 in 700.  IgA deficiency affects celiac disease tests by causing false negatives in IgA based tests such as the tTG IgA, DGP IgA and EMA IgA. Your daughters IgA is fine so IgA deficiency will not affect her test results.

 

Tissue transgluatiminase IgA (tTG IgA) is the most common test done.  It is very specific to celiac disease; somewhere between 91-99% of all positive results can be attributed to celiac disease. It is fairly sensitive but it can miss between 5 and 25% of all celiacs.  Bevause it misses a minority of celiacs it is smart to have other tests done.

 

The endomysial antibodies (EMA IgA) test is very similar to the  tTG IgA (both will indicate damage to the endomysial layer of the intestines) except that it tends to show more advanced damage.  It is tested as a titre, meaning they keep diluting it until the antibody is no longer detected.  The results will be written as 1:10, 1:20, 1:40, 1:80, 1:160, etc.  A positive is often a 1:40, which (I believe) is the last dilution the EMA IgA was found.  It is very unusual to get a positive EMA IgA if the tTG IgA was negative, but some celiacs do have negative tests in these - the sensitivity is around 80%.

 

The other tests yo want done are:

  • tTG IgG - some celiacs only have positive IgG based tests (even without the IgA deficiency) so this is good to run although many doctors don't agree for some reason
  • DGP IgA and DGP IGG - these are newer tests that are considered to be the best in detecting celiac disease in children. (deaminated gliadin peptides) I higher recommend having them run.
  • AGA IgA and AGA IgG - these are older and less reliable tests that were replaced by the DGP tests. I would have them run if you can't get the DGP test.
  • endoscopic biopsy - ensure at least 6 samples are biopsied; it can miss as many as 1 in 5 celiacs.

This report (pages 10-12) has great info on testing: http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf

 

This is an interesting article about why symptoms are not a great diagnostic tool in children:  http://pediatrics.aappublications.org/content/early/2014/01/07/peds.2012-3765.full.pdf

 

Your only other option besides the tests I listed, as I see it, is to try the gluten-free diet. Those with non-celiac gluten sensitivity (NCGS) will feel better on the gluten-free diet but will have negative blood and biopsy tests.  Do not go gluten-free until you are satisfied that all testing is done.  A gluten-free diet will eventually result in negative celiac tests.

 

Best wishes.


Nicole 

"Acceptance is the key to happiness."

ITP - 1993

Celiac - June, 2012

Hypothyroid - August, 2012

CANADIAN

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