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Why Can't I Understand This Genetic Testing?

Lilpig99

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Lilpig99 Newbie
Lilpig99
Posted

First post and trying to figure out what the genetic results mean:

Alpha 3:01, 5

Beta 3:01, 3:02

This test was HLA typing for Celiac and was done at Mayo. Still waiting for doc appt to understand the results.

Results show "permissive" for celiac and also "celiac pairs present", but I'd like to understand the numbers. Nowhere does it say HLA dq2 or HLA dq8. And these don't seem to read like other results.

Btw...my guy has a horrid amount of food allergies, eosinophilic esophagitis and duodenitis. Currently undertaking major elimination diet and repeat endoscopes. First scope showed normal villous architecture and no lymphocyte infiltration. This test was throwing the net wide to find out what's going on with vomitting etc. We had regular blood testing done for celiac but he was already on the elimination diet and not eating wheat ...so I still don't know why we did that bloodwork--it all came back zero for antibodies. Lol

Thanks for helping my make sense of the numbers...

:)))

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SMRI Collaborator
SMRI
Posted

Mayo reports their gene testing a bit strange and I still can't understand mine :D.  What were his numbers from his Celiac tests?

Lilpig99 Newbie
Lilpig99
Posted
  • Author

Here's the entire lineup:

DQ Alpha1 03:01, 05

----------------------------------------

DQ Beta1 03:01, 03:02

Serologic Equivalent: 7,8

----------------------------------------

Celia Gene Pairs Present? Yes

These genes are permissive for celiac. .....

Tissue Transglutaminase IGA 0

Gliadin IGA Antibody 0

Immunoglobulin A (IGA) Celiac 95 (range 21-291)

(Wheat IgE 3.15 Class 2)

I'm usually just fine with medical stuff but yes, Mayo's HLA typing is hard for me to understand.:(

SMRI Collaborator
SMRI
Posted

Did they run more than that?  From what these are saying, he is not Celiac, unless he is Celiac and these are follow up tests after being gluten free, which then means this is good.  The IgA that is 95 is a total IgA and they run that to make sure that is in the normal range.  Generally they run a total IgG as well.  I've never been able to get a straight answer on the gene testing here so not sure if someone will help or not.  When I asked my GI, he wasn't even sure how to read them...well, the GI intern I talked to :D. 

 

Gluten is found in more than just wheat so he may or may not have been exposed to Gluten at the time of the testing.  What was/is he eating typically at that time and how long had he been off wheat?  

 

I don't know about the Wheat IgE #s if that is normal, high, low, etc.  Did they run any other Ig anything tests?

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