Ttg igg causes other than celiac

[pupppy]

Hello, I came back negative on all the celiac tests including the gene test at labcorp except for the ttg igg, which was 12 (range 0-5). My iga is low, but I came back negative on the dgp igg and the gene test which I understand ~100% rules it out. Does this indicate anything other than celiac, or should I ignore it?

Results

Deamidated Gliadin Abs, IgA 3 units 0 - 19 Negative 0 - 19 Weak Positive 20 - 30 Moderate to Strong Positive >30

Deamidated Gliadin Abs, IgG 3 units 0 - 19 Negative 0 - 19 Weak Positive 20 - 30 Moderate to Strong Positive >30

t-Transglutaminase (tTG) IgA <2 Tissue Transglutaminase (tTG) has been identified as the endomysial antigen. Studies have demonstr- ated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy.

t-Transglutaminase (tTG) IgG 12 High U/mL 0 - 5 01 Negative 0 - 5 Weak Positive 6 - 9 Positive >9

Endomysial Antibody IgA Negative Negative 01

Immunoglobulin A, Qn, Serum 65 Low mg/dL 90 - 386

 

Celiac Disease HLA DQ Assoc.

DQ2 (DQA1 0501/0505,DQB1 02XX) Negative 02

DQ8 (DQA1 03XX, DQB1 0302) Negative 02

Final Results:

DQA1*01:SXYS,03:RV

DQB1*04:AYGMA,05:BEFZC

Code Translation:

SXYS 01/04/05/12

BEFZC 01/07/12/18/27/29/30/31/32/44/45/103/104

/105/107/133/137/139/144/148/150/152/155 RV

01/02/03/04 AYGMA

04:02/04:11/04:13/04:23/04:30/04:32/04:39 /

04:41N

The patient is not positive for any of the HLA DQ risk alleles. Celiac Disease risk from the HLA DQA/DQB genotype is approximately 1:2518 (<0.04%).

I am happy because it supposedly means I won't develop it, so I can rule it out (?). However I am wondering what could cause the ttg igg to be elevated. My parents side of the family do have autoimmune diseases so I am just wondering if I should look into it.

[ravenwoodglass]

You do have that low positive so hopefully the doctors are looking for the cause. I know there are other disorders that can raise that just a bit above positive. It won't hurt to give the diet a good strict try for a bit to see if it helps as long as you are completely done with celiac related testing. I don't understand all the info you have about genes but I do know that there are folks that are firmly diagnosed celiac and don't have one of the two genes for which they usually test. I am one of those oddballs as I have two copies of a rarer celiac associated gene, DQ9.

[pupppy]

2 hours ago, ravenwoodglass said:

You do have that low positive so hopefully the doctors are looking for the cause. I know there are other disorders that can raise that just a bit above positive. It won't hurt to give the diet a good strict try for a bit to see if it helps as long as you are completely done with celiac related testing. I don't understand all the info you have about genes but I do know that there are folks that are firmly diagnosed celiac and don't have one of the two genes for which they usually test. I am one of those oddballs as I have two copies of a rarer celiac associated gene, DQ9.

I don't understand the genetic info either but after googling it seems like DQA1*01 = DQ1. And DQB1*04 = DQ4. So DQ1 and DQ4.  

Edit: DQ1 actually seems to split into DQ5 and DQ6, and upon further investigation it says DQA1*0103. This is listed under wikipedia as DQ6.1. So I have DQ6 and DQ4 (DQB1*0405 = DQ4.3/DR4-DQ4)

[pupppy]

3 hours ago, ravenwoodglass said:

You do have that low positive so hopefully the doctors are looking for the cause. I know there are other disorders that can raise that just a bit above positive. It won't hurt to give the diet a good strict try for a bit to see if it helps as long as you are completely done with celiac related testing. I don't understand all the info you have about genes but I do know that there are folks that are firmly diagnosed celiac and don't have one of the two genes for which they usually test. I am one of those oddballs as I have two copies of a rarer celiac associated gene, DQ9.

Which disorders? My paternal side have rheumatoid arthritis and psoriasis. It was 10 when I had it checked just last month (which is what led me to get the entire panel). I was hoping, if everything came back negative, that the ttg igg would decrease also and just be a fluke, but it seems to be going up. ? 

I had mainly digestive problems which is what led me to get tested in the first place, but it seems like it was just lactose intolerance. The only other digestive diseases I can think of are crohns and colitis, but those are very severe, and I don't have bloody #2's 

[Posterboy]

2 hours ago, pupppy said:

Does this indicate anything other than celiac, or should I ignore it?

 

1 hour ago, ravenwoodglass said:

You do have that low positive so hopefully the doctors are looking for the cause. I know there are other disorders that can raise that just a bit above positive. It won't hurt to give the diet a good strict try for a bit to see if it helps as long as you are completely done with celiac related testing.

pupppy,

I agree with Ravenwoodglass.  You should give the gluten free diet a try if you are through with all your celiac testing unless you have been sick lately from something else on the UChicago list.

To answer your question.

See this UChicago link.

Open Original Shared Link

It should be noted.  Though I did not see their source material other food allergens are on their list including milk ie. lactose etc.

Many time the milk allergy is to casein not lactose.  Try some Kefir 99% lactose free to see if it the casein protein in milk.

Here are two threads that might help you.

One who had a question about Giardia possibly causing a similar issue/question.

https://www.celiac.com/forums/topic/122551-celiac-has-reversed-turned-latent-on-gluten-diet/?tab=comments#comment-996306

and one by the user sugarcube who reported getting better (ttg went down) after getting over a Giaria infection.

https://www.celiac.com/forums/topic/113893-can-treatment-for-giardia-reverse-active-celiac/

I hope this is helpful but it is  not medical advice.

Good luck on your continued journey.

Posterboy by the grace of God,

 

[pupppy]

1 hour ago, Posterboy said:

 

pupppy,

I agree with Ravenwoodglass.  You should give the gluten free diet a try if you are through with all your celiac testing unless you have been sick lately from something else on the UChicago list.

To answer your question.

See this UChicago link.

Open Original Shared Link

It should be noted.  Though I did not see their source material other food allergens are on their list including milk ie. lactose etc.

Many time the milk allergy is to casein not lactose.  Try some Kefir 99% lactose free to see if it the casein protein in milk.

Here are two threads that might help you.

One who had a question about Giardia possibly causing a similar issue/question.

https://www.celiac.com/forums/topic/122551-celiac-has-reversed-turned-latent-on-gluten-diet/?tab=comments#comment-996306

and one by the user sugarcube who reported getting better (ttg went down) after getting over a Giaria infection.

https://www.celiac.com/forums/topic/113893-can-treatment-for-giardia-reverse-active-celiac/

I hope this is helpful but it is  not medical advice.

Good luck on your continued journey.

Posterboy by the grace of God,

 

I tested negative for all parasites and I haven't been sick in over 2 years. I also had the hydrogen breath test done which came back positive for lactose intolerance

This may be a wild shot in the dark, but is there any association between ttg igg and rheumatoid arthritis? Both my grandmother and aunt have it, and it says the DR4-DQ4 is associated with it.

[Posterboy]

31 minutes ago, pupppy said:

This may be a wild shot in the dark, but is there any association between ttg igg and rheumatoid arthritis?

pupppy,

Here is a couple of quick google searches on the topic.

You can find the same thing yourself but basically 1 in 4 (at least in older studies) of celiac's also had or could go on to develop RA (especially) if your not diagnosed as a celiac first.

Here is an older celiac.com article about it.

https://www.celiac.com/celiac-disease/celiac-disease-amp-related-diseases-and-disorders/arthritis-and-celiac-disease/studies-show-high-instance-of-rheumatoid-arthritis-and-osteoporosis-in-patients-with-celiac-disease-r1139/

Here is a more up to date study on it from 2015.

Open Original Shared Link entitled "Rheumatoid arthritis–celiac disease relationship: Joints get that gut feeling"

also have your Vitamin D levels checked.

see this latest research on Vitamin D and Arthritis from 2017 entitled "Maintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis"

Open Original Shared Link

I could say this almost every post.

Take a good B-complex, magnesium citrate a Vitamin D and you will  help many of your problems.

I say a good b-complex because B's work together in the body to manage stress/inflammation in the body.

see this research on B-6 and Arthritis.

Open Original Shared Link entitled "Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis."

and this pioneering work by William Kaufman now deceased about his discoveries about arthritis from the early 50s now forgotten in the medical world. he (dr. kaufman) pioneered (when vitamins where still relatively) new to the medical world the use of Vitamins in doses above the RDA to treat inflammation and arthritis in his patients.  and found out frequency of b-vitamins are as or more important as dose size.

Open Original Shared Link

because B-vitamins are water soluble we quickly become low and if not taken 2/daily it is hard to every catch up on being too low at least for a period/cycle of time like say 3 or 4 months then frequency can be tapered to a maintenance dose of once a day.

This is especially true if you are going through something very stressful in your life.

see this livestrong article on B-Vitamins and stress.

Open Original Shared Link

and we know B-Vitamins can help Celiac's.

https://www.celiac.com/celiac-disease/celiac-disease-diagnosis-testing-amp-treatment/b-vitamins-beneficial-for-celiacs-on-gluten-free-diet-r1416/ 

In my late 20s before I received my Celiac diagnosis taking Magnesium and Vitamin D (I was low in it) helped many of the aches and pains of my early onset arthritis (joint pain) symptoms.

Here is a livestrong article on Magnesium and arthritis.

Open Original Shared Link

My symptom's improved remarkably taking both Magnesium Citrtate, Vitamin D and a good B-complex.

search for Ennis_tx, the posterboy or knitty kitty on this forum we all have been helped by either a B-complex, + Magnesium and or a  B-complex + Vitamin D supplementation.

Here is a good thread on vitamins celiac should take.

https://www.celiac.com/forums/topic/122496-i-tested-positive-for-celiac-what-vitamins-and-minerals-i-should-check/?tab=comments#comment-996029

Your vitamin D levels will probably be low if they have checked you lately.

I hope this is helpful but it is  not medical advice.

2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the grace of God,

[pupppy]

1 hour ago, Posterboy said:

pupppy,

Here is a couple of quick google searches on the topic.

You can find the same thing yourself but basically 1 in 4 (at least in older studies) of celiac's also had or could go on to develop RA (especially) if your not diagnosed as a celiac first.

Here is an older celiac.com article about it.

https://www.celiac.com/celiac-disease/celiac-disease-amp-related-diseases-and-disorders/arthritis-and-celiac-disease/studies-show-high-instance-of-rheumatoid-arthritis-and-osteoporosis-in-patients-with-celiac-disease-r1139/

Here is a more up to date study on it from 2015.

Open Original Shared Link entitled "Rheumatoid arthritis–celiac disease relationship: Joints get that gut feeling"

also have your Vitamin D levels checked.

see this latest research on Vitamin D and Arthritis from 2017 entitled "Maintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis"

Open Original Shared Link

I could say this almost every post.

Take a good B-complex, magnesium citrate a Vitamin D and you will  help many of your problems.

I say a good b-complex because B's work together in the body to manage stress/inflammation in the body.

see this research on B-6 and Arthritis.

Open Original Shared Link entitled "Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis."

and this pioneering work by William Kaufman now deceased about his discoveries about arthritis from the early 50s now forgotten in the medical world. he (dr. kaufman) pioneered (when vitamins where still relatively) new to the medical world the use of Vitamins in doses above the RDA to treat inflammation and arthritis in his patients.  and found out frequency of b-vitamins are as or more important as dose size.

Open Original Shared Link

because B-vitamins are water soluble we quickly become low and if not taken 2/daily it is hard to every catch up on being too low at least for a period/cycle of time like say 3 or 4 months then frequency can be tapered to a maintenance dose of once a day.

This is especially true if you are going through something very stressful in your life.

see this livestrong article on B-Vitamins and stress.

Open Original Shared Link

and we know B-Vitamins can help Celiac's.

https://www.celiac.com/celiac-disease/celiac-disease-diagnosis-testing-amp-treatment/b-vitamins-beneficial-for-celiacs-on-gluten-free-diet-r1416/ 

In my late 20s before I received my Celiac diagnosis taking Magnesium and Vitamin D (I was low in it) helped many of the aches and pains of my early onset arthritis (joint pain) symptoms.

Here is a livestrong article on Magnesium and arthritis.

Open Original Shared Link

My symptom's improved remarkably taking both Magnesium Citrtate, Vitamin D and a good B-complex.

search for Ennis_tx, the posterboy or knitty kitty on this forum we all have been helped by either a B-complex, + Magnesium and or a  B-complex + Vitamin D supplementation.

Here is a good thread on vitamins celiac should take.

https://www.celiac.com/forums/topic/122496-i-tested-positive-for-celiac-what-vitamins-and-minerals-i-should-check/?tab=comments#comment-996029

Your vitamin D levels will probably be low if they have checked you lately.

I hope this is helpful but it is  not medical advice.

2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included.

Posterboy by the grace of God,

Wow thanks. That is some really good information. Yes my vitamin D was very low around two years ago when the results came back, it was 7. The doctor said to supplement and eat more dairy (can’t do that now). I had been ignoring it completely, I never realized the link between RA and vitamin D. I will definitely start supplementing. As far as B vitamins go I eat meat, trying to keep it limited to seafood.

I don’t think I have celiac disease. I don’t have the genes and all my tests were negative except for the ttg igg. My iron levels are fine too. Some type of immune response is going on however, I wish I knew ? I don’t want to pester my doctor over what may be nothing

[cyclinglady]

6 hours ago, pupppy said:

Which disorders? My paternal side have rheumatoid arthritis and psoriasis. It was 10 when I had it checked just last month (which is what led me to get the entire panel). I was hoping, if everything came back negative, that the ttg igg would decrease also and just be a fluke, but it seems to be going up. ? 

I had mainly digestive problems which is what led me to get tested in the first place, but it seems like it was just lactose intolerance. The only other digestive diseases I can think of are crohns and colitis, but those are very severe, and I don't have bloody #2's 

My niece has Crohn’s.  The only symptom she had was occasional abdominal pain.  Nothing else.  We thought for sure she had celiac disease, but a pill camera caught the damage located out of reach of both scopes.  Do not assume you do not have Crohn’s, let your doctor do that.  

Open Original Shared Link

[pupppy]

40 minutes ago, cyclinglady said:

disease, but a pill camera

Wow, I guess when I read stories of ibd it seemed more severe, like going to the bathroom 20 times a day and losing weight rapidly. I was afraid to get a diagnosis like IBS or SIBO. I get relief cutting dairy from my diet, and the breath test for lactose intolerance was barely positive (~17-20 ppm increase in h2), so my only curiosity left is the blood test. I was supposed to set up an appointment with a new gi a week ago-maybe I will go just to ask about the ttg 

[pupppy]

36 minutes ago, cyclinglady said:

My niece has Crohn’s.  The only symptom she had was occasional abdominal pain.  Nothing else.  We thought for sure she had celiac disease, but a pill camera caught the damage located out of reach of both scopes.  Do not assume you do not have Crohn’s, let your doctor do that.  

Open Original Shared Link

One question, did your niece have any positive blood work?

[cyclinglady]

I am sorry, my intent was not to imply that you have Crohn’s.  I was trying to point out that trying to diagnose yourself could be dangerous.   Not everyone fits into a “box” of symptoms.  Not all doctors are perfect, but they do have years of training.  

I am glad that you have found relief from eliminating lactose from your diet.  It might be just as simple as that.  

Consider Ravenwodglass’ suggestion about dietary changes.  While not everyone needs to be gluten free, eating fewer processed foods may be better for your health.  It might reduce your chances of developing an autoimmune disease.  No guarantees, but the Standard American Diet has probably caused our obesity and other health issues.  A fascinating and long debated subject worth researching.  

 

[cyclinglady]

8 hours ago, pupppy said:

One question, did your niece have any positive blood work?

No.  So, with a couple of negative celiac blood panels and a negative biopsies, celiac disease was ruled out at the time.  

I was trying to point out that had she searched for a diagnosis on the internet without consulting with medical doctors, her diagnosis would never have been caught because she did not have classic Crohn’s symptoms.  

Your elevated TTG IgG could be something else, or it could just be a weird result.  You and your doctors know your symptoms and medical history.  It might be worth pursuing to find out the root cause or just let time reveal it.  

Take care! 

 

[pupppy]

4 hours ago, cyclinglady said:

I am sorry, my intent was not to imply that you have Crohn’s.  I was trying to point out that trying to diagnose yourself could be dangerous.   Not everyone fits into a “box” of symptoms.  Not all doctors are perfect, but they do have years of training.  

I am glad that you have found relief from eliminating lactose from your diet.  It might be just as simple as that.  

Consider Ravenwodglass’ suggestion about dietary changes.  While not everyone needs to be gluten free, eating fewer processed foods may be better for your health.  It might reduce your chances of developing an autoimmune disease.  No guarantees, but the Standard American Diet has probably caused our obesity and other health issues.  A fascinating and long debated subject worth researching.  

 

Yes I see your point, I will go to ask. I hope it’s nothing

[pupppy]

Interestingly, DQ4 is a very rare haplotype in most of the world (freq .03-2%) and is significantly associated with RA. 35/43 (81%) RA patients in a sample study had the DR4-DQ4 type, especially DQ4.1. (subtype of 4.3)

Open Original Shared Link

[cyclinglady]

The TTG can be elevated for many reasons.  This is from an old celiac.com member who has celiac disease and is a doctor.  She references the University of Chicago:

Open Original Shared Link

 

[pupppy]

50 minutes ago, cyclinglady said:

The TTG can be elevated for many reasons.  This is from an old celiac.com member who has celiac disease and is a doctor.  She references the University of Chicago:

Open Original Shared Link

 

edit: nevermind i will just wait and see what they say. The only other abnormal thing was that my "eos" was slightly *high, and the hct was borderline low (41.0%, range 41.0-50%)

[pupppy]

Edit: nvm I have dq5/dq4