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Need help interpreting blood results!

Sebastian95
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Sebastian95 Rookie
Sebastian95
Posted

Hello,

I was just looking for some help interpreting my blood results. My celiac panel had a note from the lab that states “no serological evidence found of celiac”. But my IgA was high 378 with a rang of 47-310. Can this mean celiac? I was told yea but I’m not sure. 

Any input is greatly appreciated!

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sunflowers Rookie
sunflowers
Posted
4 hours ago, Sebastian95 said:

Hello,

I was just looking for some help interpreting my blood results. My celiac panel had a note from the lab that states “no serological evidence found of celiac”. But my IgA was high 378 with a rang of 47-310. Can this mean celiac? I was told yea but I’m not sure. 

Any input is greatly appreciated!

Is that your tTg-IgA result? Or just the IgA? Usually celiac panels do an IgA test to see if you're deficient in IgA. If you are deficient in IgA, the tissue transglutaminase tests might give you a false negative and other blood tests may be required.

What were your other test results? 

Sebastian95 Rookie
Sebastian95
Posted
  • Author
5 hours ago, sunflowers said:

Is that your tTg-IgA result? Or just the IgA? Usually celiac panels do an IgA test to see if you're deficient in IgA. If you are deficient in IgA, the tissue transglutaminase tests might give you a false negative and other blood tests may be required.

What were your other test results? 

Thanks for the reply!

so the celiac panel when i look at the results are: 

The one mentioned above which is high but then I also have tTg which is in range with <1 with a range of <15 and states “antibody not detected”

please let me know if I’m missing anything!

 

knitty kitty Grand Master
knitty kitty
Posted

Were you eating gluten regularly before the test?  

Sebastian95 Rookie
Sebastian95
Posted
  • Author
Just now, knitty kitty said:

Were you eating gluten regularly before the test?  

Yes absolutely, i eat bread almost everyday and even wheat bread sometimes 

knitty kitty Grand Master
knitty kitty
Posted

Did you have any other antibody tests done like the DPG?

Sebastian95 Rookie
Sebastian95
Posted
  • Author
7 minutes ago, knitty kitty said:

Did you have any other antibody tests done like the DPG?

 So when i look at the tests this is all that was tested it does say celiac panel. 

It says “celiac disease comp panel w/Gliadin AB (IGG) 

“No serological evidence for celiac is present. tTg may normalize in individuals with celiac disease”

Tissue Transglutaminase AB, IGA: normal <1 range of <15. Antibody not detected

Immunoglobin A: Hight 378 range 47-310

thats all i see under celiac panel testing, there were other tests but not part of celiac

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knitty kitty Grand Master
knitty kitty
Posted

I would suggest the complete Celiac Disease panel. 

https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/

Anemia and Diabetes can cause false negatives, so can having Dermatitis Herpetiformis.  I'm a big fan of genetic testing.

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    • cristiana
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      Hi @CC90 Ah... that is very interesting.  Although it is very annoying for you to have to go through it all again, I would say that almost sounds like an admission that they didn't look far enough last time?   I could be wrong, but I would not be at all surprised if they find something on the next attempt.  Coeliac damage can be very patchy, as I understand it, so that's why my own gastroenterologist always likes to point out that he's taken lots of samples!  In the kindest possible way (you don't want to upset the person doing the procedure!) I'd be inclined to tell them what happened last time and to ask them in person to take samples lower down, as  if your health system is anything like the one in my country, communication between GPs, consultants and hospitals isn't always very good.  You don't want the same mistake to be made again. You say that your first endoscopy was traumatic?  May I ask, looking at your spelling of coeliac, was this done at an NHS hospital in England?  The reason for the question is that one of my NHS diagnosed friends was not automatically offered a sedative and managed without one.  Inspired by her, I tried to have an endoscopy one time, in a private setting, without one, so that I could recover quicker, but I had to request sedative in the end it was so uncomfortable.    I am sorry that you will have to go through a gluten challenge again but to make things easier, ensure you eat things containing gluten that you will miss should you have to go gluten free one day. 😂 I was told to eat 2 slices of normal wholemeal bread or the equivalent every day in the weeks before , but I also opted for Weetabix and dozens of Penguin chocolate biscuits.  (I had a very tight headache across my temple for days before the procedure, which I thought was interesting as I had that frequently growing up. - must have been a coeliac symptom!)  Anyway, I do hope you soon get the answers you are looking for and do keep us posted. Cristiana  
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