zinc deficiency The role of zinc in calprotectin expression in human myeloid (red blood) cells and its use in diagnosing IBS, IBD or Chrons

[Posterboy]

To all,

This came up in another topic thread and I wanted to do some research on it......( and I couldn't find the thread easily) if some one knows where it is ......then by all means post it there too......it was about Calprotectin levels and IBS/IBD etc.

I have been a big propent that the nutritional deficiency happens first then you have symptom's of the deficiency being diagnosed as inflammation and/or a disordered immune system and finally diagnosed as a genetic disease IE a Thiamine and Niacin deficiency leading to first NCGS and finally Celiac disease etc.

But I am not just picking on one GI disease or the other......I think it is happening in many of the GI diseases......I call the alaphabet diseases...

Like IBS, IBD, UC and Chrons etc...

Well here is good research that showw the Calprotectin levels used to determine between IBS, IBD and/or Chrons disease is really just a Zinc Deficiency?

Or that Is what I think it is according to this recent research?

And I thought I would start a thread about it and see what others think about it.

Entitled "The role of zinc in calprotectin expression in human myeloid (aka Red Blood) cells"

https://pubmed.ncbi.nlm.nih.gov/29895358/#:~:text=While a role of zinc in the regulation,calprotectin (S100A8%2FS100A9 heterodimer) expression is so far missing.

Where they note quoting

"Our findings suggest that zinc (and its deficiency) does not only regulate the activity of calprotectin but also its expression by human myeloid cells."

If you want to read the short (summarized form) of why Calprotecin is important in IBS and/or Chrons read this article.

Entitled "The Use of Fecal Calprotectin in Inflammatory Bowel Disease"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390326/

If you want to read the more technical and detailed reason(s) Calprotecin is used and why it can be a sign of a Zinc deficiency in IBS and/or Chrons then read this longer and more complex article.

Entitled "Calprotectin: from biomarker to biological function"

https://gut.bmj.com/content/70/10/1978

I hope this is helpful but it is not medical advice.

Posterboy,

[Scott Adams]

I also supplement zinc, and many of your posts make me wonder if celiac disease could be avoided in many people if they were to properly supplement. The different triggers of celiac disease in those with the genetic markers are not fully understood, and could certainly be nutritionally related.