ANA positive - Celiac and aspirin therapy

[Painful5]

So, after my missed miscarriage last year I got some bloods done.  Being celiac I wanted to get my autoimmune system checked just in case of a problem.  As it turned out, I had a pretty poor stock of vitamin D so I am now on a double dose of that but my doctor has said that next time I am pregnant I should take baby aspirin daily as research has shown it might help the situation with the positive ANA.  I don't have a high level, 1:80, homogenous, but still listed as positive and this is something they are looking into.  My doc thinks I am very likely to already have lupus or another related autoimmune disorder because I have absolutely no symptoms of any but they will obviously check this out.

My main question here relates to the asprin.  Last time I took baby aspirin for a few days I developed acid reflux and I am sure I have read the two are related.  So I have a bit of a dilema, take the aspirin when I am pregnant and hope it helps with the ANA situation but doesn't exacerbate the celiac disease/leaky gut or do without and prey not to miscarry again which, of course, may or may not be related to the ANA level.

Advice appreciated please.  Thank you

 

[trents]

Aspirin, as are all NSAIDs, is a COX 1 and COX 2 inhibitor. That means it interferes with two steps in the body's process of rebuilding the protective mucous lining of the upper GI tack. In addition it is a acidic irritant (salicylic acid). Personally, I use NSAID's very cautiously and sparingly as a celiac because we struggle with damaged gut linings already. I would be very reluctant to take baby aspirin on a regular basis.

[Scott Adams]

I take baby aspirin daily per my doctor's recommendation due to a family history of heart disease. If your doctor recommends it during pregnancy you should likely follow their advice, provided you can tolerate it. I take it directly after a full meal, and haven't had any stomach issues.

[Painful5]

Thank you for your reply too Scott. The only reason he has told me to take it is to try to reduce issues caused by the Ana's so I might ask if taking one every other day might be something to try. I just kind of thought that if I was getting acid reflux from a daily 75g pill I might be intolerant. If I hadnt been found to have been carrying a dead embryo for over six weeks I should have been taking 150g per day from 12 weeks, not too sure how I would have got on with that one. 

The doc is hoping that my taking the aspirin I can avoid taking steroids which work but can cause huge issues.  Equally, I have read in a couple of medical reports that there is a connection between low vitamin D and positive ANA so I am going to ask whether he thinks I should have a couple of infusions of vit D. My B12 is surprisingly good.

[Scott Adams]

Certainly discuss everything with your doctor, and follow their advice, but yes, I'd take aspirin over steroids any day!

[Painful5]

1 hour ago, Scott Adams said:

Certainly discuss everything with your doctor, and follow their advice, but yes, I'd take aspirin over steroids any day!

I will do, thank you Scott

[Painful5]

Interesting news this week is that my doctor did a host of new tests including a repeat ANA test. The latter is now negative. My doctor thinks that there is a possibility that I went for dinner and have been very slightly “glutened”. My body has then gone into hyper immune drive and started producing ANAs. He can’t say whether this was before my pregnancy or after. He is if the view that it can take months for the antibody level to disappear so he admits it would have had the potential to cause the miscarriage if before. 
Anyway, the upshot of this is that he has advised me not to go anywhere but my own home to eat until I have successfully produced offspring!! I am going to do exactly that.

 

[Scott Adams]

Good advice, as the most common source of contamination would be eating outside your home, especially at restaurants (even if they have items marked GF or a GF menu).