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Should I Have Been Eating Gluten Prior To These Tests?


KevinG

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KevinG Apprentice

My gastroenterologist ordered some blood tests for celiac; my results are below. His nurse told me based on the results that I don't have celiac and am not at risk for developing it. However, I had been on a gluten-free diet for months prior to the tests. (Occasionally some gluten slips in, but I am pretty careful.) Does that render the below tests invalid?

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psawyer Proficient

Your results are negative for antibodies related to celiac disease, but if you have not been eating gluten then there will not be antibodies--at least not enough to register on the test. I was retested a few years ago, and everything was normal. Does that mean that I no longer have celiac disease? NO! It means that I have been very successful in following the gluten-free diet, and there is not any gluten in my food to trigger the autoimmune response. :)

txplowgirl Enthusiast

You need to be eating the equivelant of 2 to 3 slices of bread a day for about 2 months or longer for any chance of a positive test.

Mari Enthusiast

It looks like you have one or two HLA DQ 2 markers and that means that you are predisposed to developing Celiac Disease. I can't tell exactly what test they did - they call it a molecular test which may not mean they actually determined which DQ allele(s) you inherited so we can't tell whether you are high risk or low risk. Call the lab which did the test and ask them to tell you what it means and if you would get more information if you had the DNA marker test.

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    • trents
      Yes, it does. And joint pain is another celiac symptom that is now well-recognized. 
    • ThomasA55
      Does my iron loss sound like celiac to you?
    • trents
      Being as how you are largely asymptomatic, I would certainly advise undertaking a gluten challenge in order to get formal testing for celiac disease. We have many forum participants who become violently ill when they undertake a gluten challenge and they therefore can't carry through with it. That doesn't seem to be the case with you. The reason I think it is important for you to get tested is that many or most people who don't have a formal diagnosis find it difficult to be consistent with the gluten-free diet. They find ways to rationalize that their symptoms are due to something other than celiac disease . . . especially when it becomes socially limiting.  The other factor here is by being inconsistent with the gluten free diet, assuming you do have celiac disease, you are likely causing slow, incremental damage to your gut, even though you are largely asymptomatic. It can take years for that damage to get to the point where it results in spinoff health problems. Concerning genetic testing, it can't be used for diagnosis, at least not definitively. Somewhere between 30 and 40% of the general population will have one or both of the two genes known to be associated with the development of active celiac disease. Yet, only about 1% of the general population will develop active celiac disease. But the genetic testing can be used as a rule out for celiac disease if you don't have either gene. But even so, that doesn't eliminate the possibility of having NCGS (Non Celiac Gluten Sensitivity).
    • ThomasA55
    • trents
      Welcome to the celiac.com community, @ThomasA55! Before I give my opinion on your question about whether or not you should undergo a gluten challenge, I would like to know how you react when you get a good dose of gluten? Are you largely asymptomatic or do you experience significant illness such as nausea and diarrhea? You mentioned intermittent joint pain before you began experimenting with a low gluten diet. Anything else?
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