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Confusing Blood Tests


Klo123

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Klo123 Newbie

I recently had my 6 year old daughter tested for Celiac due to family history (myself, my sister, and my uncle) and her constant complaints of her stomach aching as well as some fatigue (she would sleep for 13+ hours once a week or so). Her blood tests results are listed below:

Gliadin IGG 13.7 (<10 is normal according to lab) POSITIVE

Gliadin IGA 0.9 (<5 is normal) NEGATIVE

TTG IGG 7.1 (6-9 is a weak positive) POSITIVE

TTG IGA 1.6 (<4 is negative) NEGATIVE

Both IGG were positive and both IGA were negative. Her regular pediatrician said yes she has it, so we started her on a gluten free diet. It has been less than a week so it is hard to tell if it is working. We DO NOT want to do a biopsy on her. I have asked for a referral to a GI, but I know she will have to be back on gluten before going. I guess I was just wondering if anyone could shed some light on the confusing blood tests. Does it seem like she has? Why are her IGA levels so low?

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Jestgar Rising Star

It may be that she's IgA deficient. They could test total IgA and tell you for sure.

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ravenwoodglass Mentor

It may be that she's IgA deficient. They could test total IgA and tell you for sure.

That is quite possible, did they do a total IGA?

Also if you are going to do more testing you need to keep her on gluten. If you are not going to biopsy then go ahead and get her on the diet strictly but keep in mind that when she gets to the GI any tests he does will be negative if she is on the diet already.

Also with those positive results it is a good idea to have everyone in the family screened.

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    • trents
      From the article I linked above: DGP-IgA and DGP-IgG (Deamidated Gliadin Peptide) Blood Tests for Celiac Disease These tests measure the levels of antibodies in the blood, but specifically targets deamidated gliadin peptides, which are a type of gluten protein that can trigger an immune response in people with celiac disease. The test is not always included in adults, but should be in cases with IgA deficiency.  I'm not sure if this is a grammatical error or not but in the context, two tests are being spoken of together so it could be intended to say, "These tests". I'll ask Scott about that.
    • Kmd2024
      No they did not run a total IGA. But wouldn’t the DPG-IGA also be negative also if I was IGA deficient? They did also run a TTG-IGG and a DPG-IGG and they were also negative.
    • trents
      The DGP-IGA is valuable when celiac is suspected but the person being tested is IGA deficient. Were you tested for IGA deficiency. In other words, was there a test known as "Total IGA" ordered? Here is an overview of the various blood tests that can be run when diagnosing celiac disease:   
    • Kmd2024
      Has anyone ever negative blood work except for the DPG-IGA? Mine was 42 (reference range negative is >20. The TTG iga was negative. I have always suffered from bad gas issues and lately have been having bouts of diarrhea and constipation. I also have a bumpy rash that comes and goes below both elbows. i have an endoscopy scheduled in May but I was just wondering if anyone else had bloodwork like this and what was the end result?
    • trents
      Welcome to he forum community, @DjinnDjab! You wrote: "i just found out i may have celiac. so needless to say i no longer have friends or relationships." Are you saying that the need to eat gluten free has resulted in losing all your friends and your entire social life?
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