Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    By Jefferson Adams •

    Higher Celiac Disease Rates in Women With Infertility

    Reviewed and edited by a celiac disease expert.
    Higher Celiac Disease Rates in Women With Infertility - Photo: CC--Meagan
    Caption: Photo: CC--Meagan

    Celiac.com 03/04/2015 - Women with infertility face higher rates of celiac disease, according to a recent data analysis.

    Until now, data connecting celiac disease and infertility has been contradictory. There are currently no recommendations regarding celiac disease screening in female patients with infertility.

    Celiac.com Sponsor (A12):
    Photo: CC--MeaganA research team recently conducted a meta-analysis to find out whether women with infertility have a higher risk for celiac disease. The team included Prashant Singh MBBS; Shubhangi Arora MBBS; Suman Lal MD; Tor A. Strand MD, PhD; and Govind K. Makharia MD, DM, DNB, MNAMS.

    To source information for their analysis, the team performed a literature search using the MeSH keywords "celiac disease," "gluten," and "infertility." They based celiac diagnosis on positive patient serology and biopsies showing villous atrophy. The team extracted celiac disease data in 3 groups of women with "all cause" infertility, unexplained infertility, and a group of control subjects. They then calculated pooled odds ratio (OR) and prevalence, with 95% confidence intervals (CI).

    Of 105 relevant studies, they included five studies for calculation of pooled odds ratio. Four additional studies, where data on controls were not available, were also considered for calculation of pooled rates of celiac disease.

    The analysis showed that women with infertility had 3.5 times higher odds of having celiac disease compared with the control group (OR=3.5; 95% CI, 1.3-9; P<0.01). Similarly, odds for celiac disease in women with "unexplained infertility" were 6 times greater than for control subjects (OR=6; 95% CI, 2.4-14.6).

    Of 884 women with infertility, 20 had celiac disease indicating a pooled prevalence of 2.3% (95% CI, 1.4-3.5).

    Of 623 women with "unexplained infertility," 20 had celiac disease. The pooled prevalence of celiac disease in women with unexplained infertility was 3.2% (95% CI, 2-4.9).

    Celiac disease is more common in women with what is called "all-cause" infertility and "unexplained" infertility, than in general population.

    Infertility and unexplained infertility can point to hidden celiac disease.

    Source:

    • Open Original Shared Link

     Share
    Go to articles

    User Feedback

    Recommended Comments

    Guest farabella

    Guest farabella

    Posted

    We find this case study very interesting and we share it on our Facebook page. Thank you!

    Link to comment
    Share on other sites
    Guest Michelle

    Guest Michelle

    Posted

    I had stomach and bowel problems for 10+ years and none of my doctors could figure out what was wrong. My husband and I were also trying for 2 years to get pregnant with no success. Just so happened that I went to a new gastroenterologist when we moved to Orlando Fl. The first thing he did was test me for celiac disease. I had a positive diagnosis after endoscopy, changed my diet, felt better than I had in years, and got pregnant 3 months later!!! This was back in 2004 and my Orlando gastroenterologist had been educated in the UK where celiac disease was very common. I am definitely proof that infertility and celiac can be related.

    Link to comment
    Share on other sites
    Guest Arpitha

    Guest Arpitha

    Posted

    Nice Information...women with celiac disease have a high risk. Good to know.

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Support Celiac.com:
    Join eNewsletter
    Donate

  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):



    Celiac.com Sponsors (A17-M):



  • Related Articles

    Jefferson Adams
    Celiac.com 04/20/2011 - To follow up on research suggesting that men with celiac disease have impaired sperm quality, a team of researchers recently set out to examine fertility in men with biopsy-verified celiac disease.
    The research team included Daniela Zugna, Ph.D., Lorenzo Richiardi, M.D., Ph.D., Olof Akre, M.D., Ph.D., Olof Stephansson, M.D., Ph.D., and Jonas F. Ludvigsson, M.D., Ph.D.
    The study included 7,121 men from a national Swedish population-based cohort. All of the men had celiac disease, as defined according to duodenal-jejunal biopsy data with the presence of Marsh III villous atrophy. 
    The study followed men born between 1914 and 1990 until they turned 54, or until the study ended in 2008, whichever came first.
    Using multinomial logistic regression and Cox ...
    Jefferson Adams
    Shorter Overall Fertility Span for Women with Untreated Celiac Disease
    Celiac.com 06/20/2011 - A team of researchers set out to assess menopause-associated disorders and fertile life span in women with untreated celiac disease compared to those who followed a long-term gluten-free diet.
    The research team included Antonella Santonicola, MD, Paola Iovino, MD, Carmelina Cappello, MD, Pietro Capone, MD, Paolo Andreozzi, MD, and Carolina Ciacci, MD.
    For their study, the team recruited 33 post-menopausal women with untreated celiac disease, 25 celiac women who had followed a gluten-free diet for at least ten years before menopause, and 45 healthy volunteers as a control group.
    The team used the Menopause Rating Scale questionnaire to gather information on menopause-associated disorders among study participants. They also used the International Physical...
    Jefferson Adams
    Celiac Disease Higher in Women with Unexplained Infertility
    Celiac.com 09/30/2011 - A new study indicates that women who suffer unexplained infertility suffer higher rates of undiagnosed celiac disease than those who do not experience unexplained infertility.
    The study appeared in the May-June issue of the Journal of Reproductive Medicine.
    Using serologic screening for celiac disease as well as routine infertility testing, Janet M. Choi, M.D., of Columbia University in New York City, led a study team that included B. Lebwohl, J. Wang, S. K. Lee, J. A. Murray, M. V. Sauer and P. H. R. Green.
    Together, they assessed 191 women with infertility. The researchers confirmed four women with positive serum test results to have celiac disease. That's 2.1 percent of the 188 patients who completed testing. The women received nutritional counseling...
    Jefferson Adams
    Celiac.com 04/27/2015 - We know that women with infertility have higher rates of celiac disease than women who are not infertile.
    There's been some evidence to suggest that celiac disease might have impact women's reproductive health. However, the quest for more solid answers continues.
    A team of researchers recently set out to assess fertility and outcomes of pregnancy among women with celiac disease. The research team included Stephanie M. Moleski, Christina C. Lindenmeyer, J. Jon Veloski, Robin S. Miller, Cynthia L. Miller, David Kastenberg, and Anthony J. DiMarino. The team crafted a retrospective cohort study in which they analyzed information gathered from patients at a tertiary care celiac center, along with information gathered from members of two national celiac disease awareness...

  • Recent Activity

    1. PixieSticks
      - PixieSticks replied to PixieSticks's topic in Super Sensitive People
      2

      Working in a kitchen with gluten?

      Hi yes! I was diagnosed 10 years ago through a biopsy. I’ve been gluten free ever since but no one I’m around is gluten free. I sometimes wore a surgical mask in the kitchen. but I believe particles were still getting through. I’ll definitely look into n95 instead. thanks for the reply.
    2. BoiseNic
      - BoiseNic replied to BoiseNic's topic in Dermatitis Herpetiformis
      11

      Skinesa

      Ya I used to react to iodine, but it doesn't bother me anymore after strict adherence to a gluten-free diet for many years now. I am happy to report that for the first time ever in my life, a probiotic formula is not making me break out, but actually seems to be helping. The strains in this formula have been specifically tested to help with skin issues. It...
    3. knitty kitty
      - knitty kitty replied to Whyz's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      Feeling ill

      @Whyz, I take a combination of Thiamin (Benfotiamin), B12 Cobalamine and Pyridoxine B6 for my pain and headaches. Really works well without hurting the digestive tract. Riboflavin B2 also helps with migraines. Most newly diagnosed people have vitamin and mineral deficiencies. Check with your doctor and nutritionist. If you follow the updated...
    4. Scott Adams
      - Scott Adams replied to Brianne03's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Advantages vs. Disadvantages of having an official Celiac diagnosis

      I don't believe that existing life insurance policies require such notifications--health checks are typically done before such policies are obtained. I believe it would primarily affect any new policy you get, and perhaps any policy renewal.
    5. Scott Adams
      - Scott Adams replied to Whyz's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      6

      Feeling ill

      You could go gluten-free now, and then start eating lots of gluten for at least 2 weeks before your endoscopy--just be sure to tell your doctor about this beforehand. If your symptoms go away on a gluten-free diet, it is further evidence of celiac disease and/or non-celiac gluten sensitivity. Approximately 10x more people have non-celiac gluten sensitivity...
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      126,532
    • Most Online (within 30 mins)
      7,748
    FriendOfCeliac
    Newest Member
    FriendOfCeliac
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.9k
    • Total Posts
      69.5k
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Popular Now

    • Whyz
      6
      Feeling ill

      By Whyz
      Started

    • Art Maltman
      6
      My 5 months of Struggle

      By Art Maltman
      Started

    • JA917
      13
      A year and a half of test confusion...

      By JA917
      Started

    • Dana Gilcrease
      5
      Gluten-Free Foods

      By Dana Gilcrease
      Started

    • GardeningForHealth
      88
      10 years later, my celiac is progressing

      By GardeningForHealth
      Started

  • Popular Articles

    • Scott Adams
      60
      The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free

      By Scott Adams

    • Scott Adams
      78
      Forbidden Gluten Food List (Unsafe Ingredients)

      By Scott Adams

    • Scott Adams
      66
      Safe Gluten-Free Food List (Safe Ingredients)

      By Scott Adams

    • Scott Adams
      144
      What Are the Symptoms of Celiac Disease?

      By Scott Adams

    • Scott Adams
      72
      Gluten-Free Alcoholic Beverages

      By Scott Adams

  • Upcoming Events

×
×
  • Create New...