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Question On Biopsy Results.

elless

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elless Rookie
elless
Posted

Hey guys. After months of frustration and pain I finally got my biopsy tests back. My GI diagnosed me with ibs, but because of known improvement on a gluten free diet due to a 2 week trail and family history of auto immune conditions as well as hashimotos myself, after looking at the results I'm a little skeptical.

My primary had only ran one test the Iga while I was on a gluten light diet. I had uped my gluten intake prior to the endoscopy. But this is what the results said.

Duodenum: Patchy mild intraepithelial lymphocytosis with normal villous architecture. The finding of intraepithelial lymphocytosis with preserved villous architecture is non specific immunological phenomenon that has a large number of causes. A mild histological manifestation of gluten sensitivity is one of these causes.

Do you think I could have the beginning stages and the damage wasn't significant enough? I'm just not satisfied with ibs. I feel like that's a cop out diagnosis. I know my bowls are irritable, now why?

I requested to have both genetic tests done. And I plan on trying a gluten-free diet anyway, as the dr said it could aggregate ibs symptoms, but if it is celiac, I would really like to be positive.

Just wanted to know you alls opinions on this.

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user001 Contributor
user001
Posted

I had blood tests come back positive after being gluten-free for awhile and my biopsy also showed enough damage for diagnosis after over 4 months gluten-free. Although I did make some mistakes with cross contamination and wasn't nearly as vigilant as I am now that I am diagnosed. Everyone is different of course. If you feel like there is a chance you have celiac disease then I would pursue it further after doing a proper gluten challenge. Although I did refuse to do the gluten challenge and my doc thought it was too dangerous for me to. So again, everyone is different. I assume they are saying gluten sensitivity after these results come in? Have they explored Crohns disease?

elless Rookie
elless
Posted
  • Author

When they ran the blood tests they only ran one test. The IGA. That came back negative. The biopsy results were what was above. At this point, I'm tired of feeling sick, and the only answer I was given is IBS. I'm going to assume I have NCGS, since I've had improvement on a gluten free diet. However I was curious to know how the knowledgeable people on this forum would interpret my results. I'm not convinced ibs is an answer. I'd appreciate any thoughts.

CajunChic Explorer
CajunChic
Posted

My blood test was negative. (I've had the full celiac panel) My biopsy was just like yours, which correlates to a Marsh 1 lesion. My dr told me it was seronegative celiac. I've had the gene test (positive DQ2), felt better on the gluten-free diet, and had other reasons for biopsy results ruled out. So, He thinks I caught it at the beginning of the disease.

I was, too, dx with IBS before the biopsy and wasn't satisfied with that dx. If you feel better gluten-free, then you have your answer. Whether its beginning celiac or NCGS, treatment is the same. gluten-free for life.

I've also given up dairy, am corn and nightshade sensitive, and cannot tolerate oil or anything spicy or acidic. So gluten wasn't the only offender, as with many celiacs.

Good luck to you and hope you feel better!

elless Rookie
elless
Posted
  • Author

Thank you so much. That definitely helped. I'm on day 1 of the diet today and go for the genetic tests next week. I'm like you as well, dairy makes me sick. I'm in the bathroom with in 30 minutes. Although the lactose intolerant breath test came back negative as well.

CajunChic Explorer
CajunChic
Posted

My breath test was negative, too!

user001 Contributor
user001
Posted

You are lucky to have caught this in the beginning, hopefully that means you can make a quick recovery! I also have major issues with coffee and artificial sweeteners. If you start to develop pain or problems as you continue a GFD, make sure to keep a diary to see what is causing the problem as you may have developed other allergies or sensitivities.

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elless Rookie
elless
Posted
  • Author

Thanks so much. Everyone on this forum has been so supportive. Right now I'm just trying to deal with explaining this to my family and dealing with all the life changes.

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