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Blood Results Negative For Celiac Disease

sparklette

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sparklette Rookie
sparklette
Posted

My daughters blood test results came back this morning.

The doctor said she was showing all clear for celiac disease, but she has significantly low serum globulin levels and a low IgA level.

Does anyone know what this means? Would low IgA levels make the celiac test less accurate?

(her total serume protein levels were in the normal range, her albumin levels were in the normal rage but her globulin levels were well below the normal range).

(her IgA levels were below the normal range, but her IgG and IgM levels were in the normal range).

We have been referred to a pediatrician but I was wondering if anyone could give any insight into what these results might mean.

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happygirl Collaborator
happygirl
Posted

Depending on if she is IgA deficient, then yes, it makes the IgA based Celiac tests inaccurate. If she is IgA deficient, they may order the IgG based tests (in particular, tTG IgG instead of tTG IgA). "In individuals with known selective IgA deficiency and symptoms suggestive of celiac disease, testing with TTG IgG is recommended." Open Original Shared Link

Which Celiac blood panel tests were run? Do you have the lab work, results, and reference ranges?

sparklette Rookie
sparklette
Posted
  • Author

The tests were:

Tissue Transglutiminase Abs

Antigliadin Abs

C reactive protein

RAST + IgE

Liver function test

TSH (thyroid test)

Iron / ferritin

I dont have all of the lab work yet, the GP got some of the results verbally over the phone without exact figures. The lab reports are being sent to the pediatrician so I will ask for a copy from him on friday.

nora-n Rookie
nora-n
Posted

The two on th top of your list are the celiac tests, and the IgG version of those must be done as the ordinary ones (the ttg and antigliadin) are just done with IgA.

Note that celiac is still possible with negative tests.

Here they only do the IgA versions too, unless there is IgA deficiency.

Even total IgA within the range, but low, may skew the results.

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