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- trents replied to ThomasA55's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms11Iron loss and potential celiac.
"Risk free genetically"? Very low risk, actually. But, we are still learning about the genetics of celiac disease. Speaking of milk, some studies show that CMP (Cow's Milk Protein) can damage the small bowel villi like celiac disease does. Also, some meds (NSAIDS, Olmesartan - a blood pressure med) and some infections can also blunt SB villi. -
- trents replied to MicG's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms13
Test interpretations
@Aretaeus Cappadocia! The post you were looking for about omeprazol acting as an anti-inflammatory/immunosuppressant was made (yesterday, I believe) by knitty kitty. Current guidelines for the gluten challenge prior to an endoscopy/biopsy of the small bowel is the daily consumption of at least 10g of gluten (about the amount in 4-6 slices of wheat flour... -
- suek54 replied to BelleDeJour's topic in Dermatitis Herpetiformis11Dermatitis Herpetiformis - follow up dermatology appointment coming up
Hi Belle, I saw eight different medics before the last one said she knew exactly what it was, so I understand where you are coming from there. And that's all it takes, just one medic who goes the extra mile to help you. I can only encourage you to keep querying the possibility of dermatitis herpetiformis and asking for the biopsy. If the biopsy is... -
- Ginarwebb replied to MicG's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms13Test interpretations
Good point - I was on omeprazole daily until about 6 months ago .. and just recently started taking them again hopefully only temporarily .. but I'll make sure to keep that in mind -
- Aretaeus Cappadocia replied to MicG's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms13Test interpretations
You're welcome! After posting earlier today, I saw another post here (can't find it again, of course) suggesting that omeprazole also acts as an anti-inflammatory/immunosuppressant. You said you were treated for h. pylori - if you are currently taking a PPI you might want to ask your Dr if it could interfere with getting a clear biopsy result (an anti-inflammatory...
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Posts
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"Risk free genetically"? Very low risk, actually. But, we are still learning about the genetics of celiac disease. Speaking of milk, some studies show that CMP (Cow's Milk Protein) can damage the small bowel villi like celiac disease does. Also, some meds (NSAIDS, Olmesartan - a blood pressure med) and some infections can also blunt SB villi. -
@Aretaeus Cappadocia! The post you were looking for about omeprazol acting as an anti-inflammatory/immunosuppressant was made (yesterday, I believe) by knitty kitty. Current guidelines for the gluten challenge prior to an endoscopy/biopsy of the small bowel is the daily consumption of at least 10g of gluten (about the amount in 4-6 slices of wheat flour bread) for at least two weeks prior to the day of the procedure. @Ginarwebb, your tTG-IGA >250 would seem to be a pretty high test result, though to be sure of that statement, I would need to see what the lab used for a "normal" range. Do you have that number also? Different labs use different scales. There isn't an industry standard yet. The tTG-IGA is the centerpiece of celiac blood antibody testing. Your ENDOMYSIAL ANTIBODY SCR (IGA) W/REFL TO TITER (aka, "EMA") is positive as well. This is an older test, and a relative expensive one, compared to the tTG-IGA which has largely replaced. But the EMA is still ordered by some docs and is highly reliable. That both of them agree in your case and this is strong evidence that you have celiac disease. Concerning the ENDOMYSIAL ANTIBODY TITER (aka, "total IGA") being high, there are two things of importance. First, it tells us you are not "IGA deficient" such that your tTG-IGA test result is reliable. Second, a high total IGA test score can suggest other health concerns, some of which are serious. It can also mean nothing. Talk to your doctor about this. I would also suggest you research the implications of a high total IGA. In addition to IGA celiac diagnostic tests there are also IGG tests which are handy when total IGA is sub normal. Here is an article outlining the various tests that can be run for diagnosing celiac disease:
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Hi Belle, I saw eight different medics before the last one said she knew exactly what it was, so I understand where you are coming from there. And that's all it takes, just one medic who goes the extra mile to help you. I can only encourage you to keep querying the possibility of dermatitis herpetiformis and asking for the biopsy. If the biopsy is positive it opens the necessary doors for you going forward. If its negative you could have an allergy to wheat (as opposed to the autoimmune reaction, which is dermatitis herpetiformis). This could even explain why you feel better so quickly after cutting out gluten. Hang on in there. Sue
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Good point - I was on omeprazole daily until about 6 months ago .. and just recently started taking them again hopefully only temporarily .. but I'll make sure to keep that in mind
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By Aretaeus Cappadocia · Posted
You're welcome! After posting earlier today, I saw another post here (can't find it again, of course) suggesting that omeprazole also acts as an anti-inflammatory/immunosuppressant. You said you were treated for h. pylori - if you are currently taking a PPI you might want to ask your Dr if it could interfere with getting a clear biopsy result (an anti-inflammatory might calm the celiac inflammation and mask the damage enough to fool the biopsy). They may (or may not) recommend ramping down then taking a holiday until after the biopsy.
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