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DMarie1017

GLIADIN DEAMIDATED AB,IGG question

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I believe normal on this test is less than 5.  My results were 34.  Dr suggested endoscopy to confirm celiac.  I've been told by some this is the test to have, others say not reliable but now my son is being tested as well.  I hate to put him through stuff he doesn't need.  Can anyone shed light on the reliability of this test? 

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2 hours ago, DMarie1017 said:

I believe normal on this test is less than 5.  My results were 34.  Dr suggested endoscopy to confirm celiac.  I've been told by some this is the test to have, others say not reliable but now my son is being tested as well.  I hate to put him through stuff he doesn't need.  Can anyone shed light on the reliability of this test? 

So, there have been some recent articles, like in the last several months, looking at folks with a positive on the test and absolutely no damage on endo.  Previously it was believed to be a very specific test however it looks like they're shedding light on the fact that this may not be the case, at least not to the extent previously thought.

That being said, I have been informed by two specialists it's better than the older gliadin test and that the IGG antibody is a bit more reliable then IGA. There are members here with confirmed celiac who only test positive to DGP. 

 Have you done the genetic test yet? That would be a way to at least rule out the possibility of celiac.  If you are gene negative it's highly unlikely you have the disease but if you are gene positive you might. 30 to 40% of the population has the gene though. 

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I am one who tests only positive (even on follow-up testing) to the DGP IgA.  My biopsies revealed a Marsh Stage IIIB.  With a result like yours, I would follow-up with an endoscopy and obtain at least six samples.  Find a GI who has celiac patients.  If the biopsies are negative, I would suggest going gluten free for six months.  While you might not have celiac disease, you might have a sensitivity to gluten or FODMAPS.  Unfortunately, there is no test for it.  Celiac disease has to be ruled out first.  

I am sorry that science has not caught up to so many GI issues.   I hope you fell better soon. 

Oh, read this.  This is current study and it recommends an endoscopy with positive DPG.  Note that only a small number do go on to a celiac diagnosis, but I would not let that stop you. If my GI did not move forward, I would have never known.  

https://celiacdiseasecenter.columbia.edu/sites/default/files/Diagnostic-Yield-of-Isolated-Deamidated-Gliadin-Peptide-Antibody-Elevation-for-Celiac-Disease.pdf

 

Edited by cyclinglady

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12 hours ago, cyclinglady said:

I am one who tests only positive (even on follow-up testing) to the DGP IgA.  My biopsies revealed a Marsh Stage IIIB.  With a result like yours, I would follow-up with an endoscopy and obtain at least six samples.  Find a GI who has celiac patients.  If the biopsies are negative, I would suggest going gluten free for six months.  While you might not have celiac disease, you might have a sensitivity to gluten or FODMAPS.  Unfortunately, there is no test for it.  Celiac disease has to be ruled out first.  

I am sorry that science has not caught up to so many GI issues.   I hope you fell better soon. 

Oh, read this.  This is current study and it recommends an endoscopy with positive DPG.  Note that only a small number do go on to a celiac diagnosis, but I would not let that stop you. If my GI did not move forward, I would have never known.  

https://celiacdiseasecenter.columbia.edu/sites/default/files/Diagnostic-Yield-of-Isolated-Deamidated-Gliadin-Peptide-Antibody-Elevation-for-Celiac-Disease.pdf

 

CyclingLady, were you deficient in IGA as well? I'm just asking because my TTG was negative (less than 1), but my IGA was normal. I'm still waiting for my biopsy result, I should have it by next week. I'm just curious if a negative TTG with a normal IGA is possible with celiac.

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My IgA was 16, with 15 being negative, and my biopsies were positive for celiac.  My IgG was 84, with 15 being negative.  My TTG has always been negative, causing me to go undiagnosed my entire life.  The gluten-free diet has literally changed my life.  

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5 hours ago, GalaxyDuster said:

CyclingLady, were you deficient in IGA as well? I'm just asking because my TTG was negative (less than 1), but my IGA was normal. I'm still waiting for my biopsy result, I should have it by next week. I'm just curious if a negative TTG with a normal IGA is possible with celiac.

Yes, it is absolutely possible. 

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8 hours ago, GalaxyDuster said:

CyclingLady, were you deficient in IGA as well? I'm just asking because my TTG was negative (less than 1), but my IGA was normal. I'm still waiting for my biopsy result, I should have it by next week. I'm just curious if a negative TTG with a normal IGA is possible with celiac.

My IgA deficiency result was (and still is) way above range, but that is most likey attributed to having other AI issues like Hashi's.  

About 10% of celiacs are seronegative.  Keep that in mind.  And if your biopsy is normal, consider giving the gluten-free diet a trial.  Whatever you do, continue to advocate for your health.  Something is making you sick.

Edited by cyclinglady

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