Jump to content

  • You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

GLIADIN DEAMIDATED AB,IGG question

DMarie1017

Recommended Posts

DMarie1017 Newbie
DMarie1017
Posted

I believe normal on this test is less than 5.  My results were 34.  Dr suggested endoscopy to confirm celiac.  I've been told by some this is the test to have, others say not reliable but now my son is being tested as well.  I hate to put him through stuff he doesn't need.  Can anyone shed light on the reliability of this test? 

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


ironictruth Proficient
ironictruth
Posted
2 hours ago, DMarie1017 said:

I believe normal on this test is less than 5.  My results were 34.  Dr suggested endoscopy to confirm celiac.  I've been told by some this is the test to have, others say not reliable but now my son is being tested as well.  I hate to put him through stuff he doesn't need.  Can anyone shed light on the reliability of this test? 

So, there have been some recent articles, like in the last several months, looking at folks with a positive on the test and absolutely no damage on endo.  Previously it was believed to be a very specific test however it looks like they're shedding light on the fact that this may not be the case, at least not to the extent previously thought.

That being said, I have been informed by two specialists it's better than the older gliadin test and that the IGG antibody is a bit more reliable then IGA. There are members here with confirmed celiac who only test positive to DGP. 

 Have you done the genetic test yet? That would be a way to at least rule out the possibility of celiac.  If you are gene negative it's highly unlikely you have the disease but if you are gene positive you might. 30 to 40% of the population has the gene though. 

cyclinglady Grand Master
cyclinglady
Posted

I am one who tests only positive (even on follow-up testing) to the DGP IgA.  My biopsies revealed a Marsh Stage IIIB.  With a result like yours, I would follow-up with an endoscopy and obtain at least six samples.  Find a GI who has celiac patients.  If the biopsies are negative, I would suggest going gluten free for six months.  While you might not have celiac disease, you might have a sensitivity to gluten or FODMAPS.  Unfortunately, there is no test for it.  Celiac disease has to be ruled out first.  

I am sorry that science has not caught up to so many GI issues.   I hope you fell better soon. 

Oh, read this.  This is current study and it recommends an endoscopy with positive DPG.  Note that only a small number do go on to a celiac diagnosis, but I would not let that stop you. If my GI did not move forward, I would have never known.  

Open Original Shared Link

 

GalaxyDuster Apprentice
GalaxyDuster
Posted
12 hours ago, cyclinglady said:

I am one who tests only positive (even on follow-up testing) to the DGP IgA.  My biopsies revealed a Marsh Stage IIIB.  With a result like yours, I would follow-up with an endoscopy and obtain at least six samples.  Find a GI who has celiac patients.  If the biopsies are negative, I would suggest going gluten free for six months.  While you might not have celiac disease, you might have a sensitivity to gluten or FODMAPS.  Unfortunately, there is no test for it.  Celiac disease has to be ruled out first.  

I am sorry that science has not caught up to so many GI issues.   I hope you fell better soon. 

Oh, read this.  This is current study and it recommends an endoscopy with positive DPG.  Note that only a small number do go on to a celiac diagnosis, but I would not let that stop you. If my GI did not move forward, I would have never known.  

Open Original Shared Link

 

CyclingLady, were you deficient in IGA as well? I'm just asking because my TTG was negative (less than 1), but my IGA was normal. I'm still waiting for my biopsy result, I should have it by next week. I'm just curious if a negative TTG with a normal IGA is possible with celiac.

Gluten-free me Newbie
Gluten-free me
Posted

My IgA was 16, with 15 being negative, and my biopsies were positive for celiac.  My IgG was 84, with 15 being negative.  My TTG has always been negative, causing me to go undiagnosed my entire life.  The gluten-free diet has literally changed my life.  

ironictruth Proficient
ironictruth
Posted
5 hours ago, GalaxyDuster said:

CyclingLady, were you deficient in IGA as well? I'm just asking because my TTG was negative (less than 1), but my IGA was normal. I'm still waiting for my biopsy result, I should have it by next week. I'm just curious if a negative TTG with a normal IGA is possible with celiac.

Yes, it is absolutely possible. 

cyclinglady Grand Master
cyclinglady
Posted
8 hours ago, GalaxyDuster said:

CyclingLady, were you deficient in IGA as well? I'm just asking because my TTG was negative (less than 1), but my IGA was normal. I'm still waiting for my biopsy result, I should have it by next week. I'm just curious if a negative TTG with a normal IGA is possible with celiac.

My IgA deficiency result was (and still is) way above range, but that is most likey attributed to having other AI issues like Hashi's.  

About 10% of celiacs are seronegative.  Keep that in mind.  And if your biopsy is normal, consider giving the gluten-free diet a trial.  Whatever you do, continue to advocate for your health.  Something is making you sick.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      134,077
    • Most Online (within 30 mins)
      10,442
    terrificterry
    Newest Member
    terrificterry
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.7k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      Sigh. I posted this yesterday based on the Safeway website. I went back again today to their website to double check. On the page where they are selling Vanilla Bean flavor, it has a distinct Certified Gluten Free label. Other flavors on the Safeway website didn't have the gluten-free statement. Today I went into the store. None of the flavors I looked at, including Vanilla Bean, have a Gluten Free statement. Is it safe? Who knows. The ingredients are either safe or nearly safe (some have "natural flavor"). There are warnings about "contains milk and soy" but not about wheat - this implies they are safe, but again, who knows. On the other hand, every flavor I checked of their Slow Churn line of ice creams has wheat as an ingredient. 100% not safe.
    • knitty kitty
      Edy's and Dreyer's ice cream

      By knitty kitty · Posted

      Do keep in mind that many of the newly diagnosed have lactose intolerance.  This is because the villi lining the intestinal tract are damaged, and can no longer make the enzyme lactAse which breaks down the milk sugar lactOse.  When the villi grow back (six months to two years), they can again produce the enzyme lactAse, and lactose intolerance is resolved.  However, some people (both those with and without Celiac Disease) are genetically programmed to stop producing lactase as they age.   Do be aware that many processed foods, including ice cream, use Microbial Transglutaminase, a food additive commonly called "meat glue," used to enhance texture and flavor.  This microbial transglutaminase has the same immunogenicity as tissue transglutaminase which the body produces in response to gluten in people with Celiac Disease.  Tissue Transglutaminase (tTg IgA) is measured to diagnose Celiac Disease in blood tests.  Microbial Transglutaminase acts the same as Tissue Transglutaminase, causing increased intestinal permeability and inflammation.   New findings show that microbial transglutaminase may be able to trigger Celiac Disease and other autoimmune and neurodegenerative diseases.   Microbial Transglutaminase is not required to be listed on ingredients labels as it's considered a processing aid, not an ingredient in the U.S.  Microbial Transglutaminase has been GRAS for many years, but that GRAS standing is being questioned more and more as the immunogenicity of microbial transglutaminase is being discovered. Interesting Reading:  Microbial Transglutaminase Is a Very Frequently Used Food Additive and Is a Potential Inducer of Autoimmune/Neurodegenerative Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC8537092/
    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      There is a 10 year old post in this forum on Edy's and Dreyer's ice cream. The information is somewhat outdated and the thread is closed to further comment, so here is a new one. Edy's And Dreyer's Grand Vanilla Bean Ice Cream - 1.5 Quart is labeled "Gluten Free". This is a different answer than years gone by. I don't know the answer for any other flavor at this moment. On 1 May, 2026, Edy's website says: "As a general rule, the gluten in Edy's and Dreyer's® frozen dessert products is present only in the added bakery products, such as cookies, cake or brownies. We always label the eight major food allergens on our package by their common name. We recommend to always check the label for the most current information before purchasing and/or consuming a product. The exception to this rule is our Slow Churned French Silk frozen dairy dessert, which contains gluten in the natural flavors." https://www.icecream.com/us/en/brands/edys-and-dreyers/faq It seems that Edy's and Dreyer's are more celiac-friendly than they were 10 years ago. Once I found enough information to make today's buying decision, I stopped researching.
    • Aretaeus Cappadocia
      EDG 3 years ago fine, now it shows focal villous blunting,

      By Aretaeus Cappadocia · Posted

      probably not your situation @Mimiof2, but allow me to add one more to @trents list of celiac-mimics: "olmesartan-induced sprue-like enteropathy"  
    • knitty kitty
      Terrible Neurological Symptoms

      By knitty kitty · Posted

      My dad had an Abdominal Aortic Aneurysm.  Fortunately, it was discovered during an exam.  The doctor could feel my dad's heart beating in his stomach/abdomen.  The aneurysm burst when the doctor first touched it in surgery.  Since he was already hooked up to the bypass machine, my dad survived ten more years.  Close call! Triple A's can press on the nerves in the spinal cord causing leg pain.  I'm wondering if bowing the head might have increased the pressure on an aneurysm and then the nerves.   https://gulfcoastsurgeons.com/understanding-abdominal-aortic-aneurysm-symptoms-and-causes/ Abdominal Aortic Aneurysm Presenting as a Claudication https://pmc.ncbi.nlm.nih.gov/articles/PMC4040638/
×
×
  • Create New...