Celiac testing done - confused about results!

[Crhawk]

Hi all... I've had digestive issues my entire life - occasional constipation, frequent nausea, abdominal pain, sometimes severe, fullness,  etc. Had an endoscopy eight years ago and requested celiac biopsy which was negative. But did have acid reflux,  gastritis and esophagitis.  Also have done functional medicine stool testing which showed high inflammation and poor absorbtion of nutrients. My aunt was recently diagnosed with celiac. 

Just got results from a recent trip to Mayo, and doctor wanted me to do a blood test. I'm confused about the results and know NOTHING about gene testing. Can anyone help me interpret? 

His note reads :

"Permissive genes present, although serology is negative. Celiac disease unlikely. However, approximately 10% of patients with celiac disease are seronegative. Also, patients who are adhering to a gluten-free diet may be seronegative." (Not on gluten free diet) 

then it says: "gene pairs present? "= "Method: Molecular typing of HLA antigens performed using reverse SSOP and/or SSP methods, reported as serological equivalents and low to medium resolution molecular values. Performing Laboratory"

DQ Alpha 1 = 03,06:01

DQ beta 1= 03:01,03:02 DQ Serologic Equivalent: 7,8

IgA(S) = 290 mg/dl

IgA,Tissue Transglutaminase Ab, S = 2.5 u/ml

 

Thanks so much for any help you can provide!  Totally new to all this, and so sick of never having real answers for all my issues!  

[cyclinglady]

7 hours ago, Crhawk said:

Hi all... I've had digestive issues my entire life - occasional constipation, frequent nausea, abdominal pain, sometimes severe, fullness,  etc. Had an endoscopy eight years ago and requested celiac biopsy which was negative. But did have acid reflux,  gastritis and esophagitis.  Also have done functional medicine stool testing which showed high inflammation and poor absorbtion of nutrients. My aunt was recently diagnosed with celiac. 

Just got results from a recent trip to Mayo, and doctor wanted me to do a blood test. I'm confused about the results and know NOTHING about gene testing. Can anyone help me interpret? 

His note reads :

"Permissive genes present, although serology is negative. Celiac disease unlikely. However, approximately 10% of patients with celiac disease are seronegative. Also, patients who are adhering to a gluten-free diet may be seronegative." (Not on gluten free diet) 

then it says: "gene pairs present? "= "Method: Molecular typing of HLA antigens performed using reverse SSOP and/or SSP methods, reported as serological equivalents and low to medium resolution molecular values. Performing Laboratory"

DQ Alpha 1 = 03,06:01

DQ beta 1= 03:01,03:02 DQ Serologic Equivalent: 7,8

IgA(S) = 290 mg/dl

IgA,Tissue Transglutaminase Ab, S = 2.5 u/ml

 

Thanks so much for any help you can provide!  Totally new to all this, and so sick of never having real answers for all my issues!  

Gene testing for celiac disease is just a tool to help RULE OUT a diagnosis.  Why?  Some 30% or more of the population carries the genes that develop into celiac disease, but only a few actually go on to develop celiac disease.  

You could be seronegative or you could be like me and test negative to the TTG tests.  Consider asking for the rest of the blood panel.  Ask your Aunt how she did on her blood panel and share with your doctor.  

[Jmg]

8 hours ago, Crhawk said:

Thanks so much for any help you can provide!  Totally new to all this, and so sick of never having real answers for all my issues! 

Follow CL's good advice above, but if once you've followed through on any further testing if it's negative for celiac consider trialling the gluten free diet regardless. I suffered from all those things and more and tested negative, but they all cleared up once I removed gluten

Good luck!