Jump to content

  • You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

Biopsy results – very confusing

tali

Recommended Posts

tali Rookie
tali
Posted

Hello

 I don’t understand what the biopsy-results means- Is it celiac or not:

" 'duodenal mucosa showing mild blunting of villi

Increased intraepithelial lymphocytes present

The finding are non specific ' raise differential diagnosis including peptic or medication injury, early celiac disease "

Thank you

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


cyclinglady Grand Master
cyclinglady
Posted

Well, your case is unusual.  If I recall your EMA was indeterminate and your TTG IgA was barely positive.  The TTG can be slightly elevated (besides celiac disease) when you have another autoimmune disorder.  Your doctor also ran an asca IgG test which can check for Inflammatory Bowel Disease (includes Crohn’s Disease).  Many other things can cause villi blunting besides celiac disease like taking a lot of ibuprofen or rarely Crohn’s.   

Your blood test result posting stated that you had no symptoms.  What prompted your doctor to test you?  

I think your best bet is to talk to your doctor.  He/She mostly likely knows the entire picture.  

Hang in there!  

tali Rookie
tali
Posted
  • Author

Thank you so much for your  answer . 

The doctor tested me due to Celiac in my family (nephew) 

I got an email from the doctor right now  -  that another biopsy is needed ...

The never ending story

thank you for you generosity , time and sharing you knowledge...

cyclinglady Grand Master
cyclinglady
Posted

Consider asking your GI to order the rest of celiac blood panel which includes the DGP tests.  Why?  I tested positive to only the DGP.  My EMA and TTG tests have always been negative even in follow up testing.  The TTG is good, but does not catch all celiacs.  This might prevent that second endoscopy.  After all, he found villi damage.    Also some 10% of celiacs are seronegative. In that case a gluten-free diet is trialed.    Sadly, you can have more than one autoimmune disorder (like me). 

My niece was diagnosed with Crohn’s.  We thought for sure that she had celiac disease.  Her fourth GI finally ordered a pill camera.  The Crohn’s damage was found out of reach from both scopes.  She must always  be on the look out for celiac disease as it is genetic and it can develop at any age.  

I wish you well!  

  • 2 weeks later...
tali Rookie
tali
Posted
  • Author
On 27.11.2017 at 5:04 PM, cyclinglady said:

Consider asking your GI to order the rest of celiac blood panel which includes the DGP tests.  Why?  I tested positive to only the DGP.  My EMA and TTG tests have always been negative even in follow up testing.  The TTG is good, but does not catch all celiacs.  This might prevent that second endoscopy.  After all, he found villi damage.    Also some 10% of celiacs are seronegative. In that case a gluten-free diet is trialed.    Sadly, you can have more than one autoimmune disorder (like me). 

My niece was diagnosed with Crohn’s.  We thought for sure that she had celiac disease.  Her fourth GI finally ordered a pill camera.  The Crohn’s damage was found out of reach from both scopes.  She must always  be on the look out for celiac disease as it is genetic and it can develop at any age.  

I wish you well!  

Thank you . I will ask my Gi for the DGP .

wish you good health !

 

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      134,077
    • Most Online (within 30 mins)
      10,442
    terrificterry
    Newest Member
    terrificterry
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.7k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      Sigh. I posted this yesterday based on the Safeway website. I went back again today to their website to double check. On the page where they are selling Vanilla Bean flavor, it has a distinct Certified Gluten Free label. Other flavors on the Safeway website didn't have the gluten-free statement. Today I went into the store. None of the flavors I looked at, including Vanilla Bean, have a Gluten Free statement. Is it safe? Who knows. The ingredients are either safe or nearly safe (some have "natural flavor"). There are warnings about "contains milk and soy" but not about wheat - this implies they are safe, but again, who knows. On the other hand, every flavor I checked of their Slow Churn line of ice creams has wheat as an ingredient. 100% not safe.
    • knitty kitty
      Edy's and Dreyer's ice cream

      By knitty kitty · Posted

      Do keep in mind that many of the newly diagnosed have lactose intolerance.  This is because the villi lining the intestinal tract are damaged, and can no longer make the enzyme lactAse which breaks down the milk sugar lactOse.  When the villi grow back (six months to two years), they can again produce the enzyme lactAse, and lactose intolerance is resolved.  However, some people (both those with and without Celiac Disease) are genetically programmed to stop producing lactase as they age.   Do be aware that many processed foods, including ice cream, use Microbial Transglutaminase, a food additive commonly called "meat glue," used to enhance texture and flavor.  This microbial transglutaminase has the same immunogenicity as tissue transglutaminase which the body produces in response to gluten in people with Celiac Disease.  Tissue Transglutaminase (tTg IgA) is measured to diagnose Celiac Disease in blood tests.  Microbial Transglutaminase acts the same as Tissue Transglutaminase, causing increased intestinal permeability and inflammation.   New findings show that microbial transglutaminase may be able to trigger Celiac Disease and other autoimmune and neurodegenerative diseases.   Microbial Transglutaminase is not required to be listed on ingredients labels as it's considered a processing aid, not an ingredient in the U.S.  Microbial Transglutaminase has been GRAS for many years, but that GRAS standing is being questioned more and more as the immunogenicity of microbial transglutaminase is being discovered. Interesting Reading:  Microbial Transglutaminase Is a Very Frequently Used Food Additive and Is a Potential Inducer of Autoimmune/Neurodegenerative Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC8537092/
    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      There is a 10 year old post in this forum on Edy's and Dreyer's ice cream. The information is somewhat outdated and the thread is closed to further comment, so here is a new one. Edy's And Dreyer's Grand Vanilla Bean Ice Cream - 1.5 Quart is labeled "Gluten Free". This is a different answer than years gone by. I don't know the answer for any other flavor at this moment. On 1 May, 2026, Edy's website says: "As a general rule, the gluten in Edy's and Dreyer's® frozen dessert products is present only in the added bakery products, such as cookies, cake or brownies. We always label the eight major food allergens on our package by their common name. We recommend to always check the label for the most current information before purchasing and/or consuming a product. The exception to this rule is our Slow Churned French Silk frozen dairy dessert, which contains gluten in the natural flavors." https://www.icecream.com/us/en/brands/edys-and-dreyers/faq It seems that Edy's and Dreyer's are more celiac-friendly than they were 10 years ago. Once I found enough information to make today's buying decision, I stopped researching.
    • Aretaeus Cappadocia
      EDG 3 years ago fine, now it shows focal villous blunting,

      By Aretaeus Cappadocia · Posted

      probably not your situation @Mimiof2, but allow me to add one more to @trents list of celiac-mimics: "olmesartan-induced sprue-like enteropathy"  
    • knitty kitty
      Terrible Neurological Symptoms

      By knitty kitty · Posted

      My dad had an Abdominal Aortic Aneurysm.  Fortunately, it was discovered during an exam.  The doctor could feel my dad's heart beating in his stomach/abdomen.  The aneurysm burst when the doctor first touched it in surgery.  Since he was already hooked up to the bypass machine, my dad survived ten more years.  Close call! Triple A's can press on the nerves in the spinal cord causing leg pain.  I'm wondering if bowing the head might have increased the pressure on an aneurysm and then the nerves.   https://gulfcoastsurgeons.com/understanding-abdominal-aortic-aneurysm-symptoms-and-causes/ Abdominal Aortic Aneurysm Presenting as a Claudication https://pmc.ncbi.nlm.nih.gov/articles/PMC4040638/
×
×
  • Create New...