Struggling with gluten challenge and not sure it’s worth it - looking for advice / experiences / encouragement

[Known1]

@trents Certainly an interesting read.  That article also fails to mention the other genes that Kitty pointed out, HLA DQ 5, 7, and 9.  With that said, the OP may find that article of interest as well? 

I decided to hit up Uncle Google to see if I could find a more inclusive test.  I found two from the same manufacturer.  However, I do not believe they can be done at home.  Nor do I know which labs in the USA offer these tests.  I would imagine contacting the manufacturer would be the fastest way to find the answer to those questions.  There are likely other tests out there as well.  These are just my findings based on 5-minutes of research.  It's good to know that more inclusive tests do exist.

https://emb.eurospital.com/en/diagnostic-tests/xeligenxl/ - blood test only

https://emb.eurospital.com/en/diagnostic-tests/xeligen-lyo/ - blood or cheek swab test

[trents]

To begin with, it might be a good idea to have knitty kitty supply some links in support of the information she gave about the additional celiac genes. From my own quick research earlier today, the only information I could find about additional celiac genes had to do with genes that complemented DQ2 and DQ8 but were not foundational in providing the potential to develop celiac disease in and of themselves. In other words, they did not provide the potential for the development of celiac disease apart from DQ2 and/or DQ8.

[knitty kitty]

The development of genetics is progressing at such a rapid rate!  It's mind boggling!

Population screening of adults identifies novel genetic variants associated with celiac disease

https://www.nature.com/articles/s41598-025-04421-6?fromPaywallRec=false

The HLA complex and coeliac disease

https://pubmed.ncbi.nlm.nih.gov/33707057/

[Scott Adams]

19 hours ago, Known1 said:

I am still amazed at all of the great information and discussions found here on Celiac.com.  Based on the quote above, what are you thoughts on this "Celiac.com Sponsored Post" from March 15th, 2026?  Are there better mail in type tests that cover the additional genes that you mentioned?

 

This new company claims to offer the most comprehensive genetic tests on the market for celiac disease, and we'll be doing a product review article (sponsored) on them soon.

[knitty kitty]

I found these articles interesting.

Among people already diagnosed with Celiac Disease, the HLA DQ B1*02 allele is present in about 95%......

Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening

https://pubmed.ncbi.nlm.nih.gov/32256023/

 

Total IgA levels can be affected by the same HLA DQ B1*02 allele.....

Total serum IgA levels and HLA-DQB1*02:01 allelic status

https://pubmed.ncbi.nlm.nih.gov/37725324/