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Chakra2

Anyone Else Dq2.2 Homozygous? I Have Q's For You.

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Does anyone else here know that they have 2 copies of the DQ2.2 gene? I would be interested to know more about what your symptoms were/are and what the age of onset was for those symptoms. And if we're related! (ha, ha)

I had daily vomiting as an infant, bladder infections and constipation as a child, waning of symptoms until adolesence, joint pain/mild digestive issues/lots of belching and gas as a teenager, mild anemia/low good cholesterol/severe D alternating with C/ sudden dairy intolerance after college, waning of symptoms in grad school (except by then I thought of D and C cycles as normal digestion), then at 33 one year after first child born symptoms became more problematic. Bloating, lower abdominal pain with every meal, seemed suddenly "allergic" to all kinds of food that had never bothered me before, continued hairloss long after postpartum time period, fatigue, depression, irritability, and the continuing D and C.

Just curious about how many out there have diagnosed celiac with 2.2/2.2, how many have gluten intolerance, and whether or not the severity of symptoms in either of those cases is linked to having the "lower-risk" genes.

Thanks!

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I had the test at Enterolab and have 2 DQ2 markers - 302 and 602. They did list the serologic equlivent but can't remember it. There was a note that said I had one main celiac gene and the second DQ2 made the disease worse. I had symptoms of low energy, food sensitivities by age 4, and slow growth, leg pains. I didn't begin to have intestinal problems until I had a Salmonella infection when I was 19. I developed endometriosis in my 20's and increasing problems with chemical sensitivities. I never felt well but Drs kept telling me I was OK, just get more rest. One brother developed Type 1 Diabetes in his 30's and all 4 of us sibs had food sensitivities as young children.


DQ6/DQ8

HLA-DQ B allele 1 *0602: HLA-DQ B allele 2 *0302

Gluten free and Cow Dairy free since 2006

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Does anyone else here know that they have 2 copies of the DQ2.2 gene? I would be interested to know more about what your symptoms were/are and what the age of onset was for those symptoms. And if we're related! (ha, ha)

I had daily vomiting as an infant, bladder infections and constipation as a child, waning of symptoms until adolesence, joint pain/mild digestive issues/lots of belching and gas as a teenager, mild anemia/low good cholesterol/severe D alternating with C/ sudden dairy intolerance after college, waning of symptoms in grad school (except by then I thought of D and C cycles as normal digestion), then at 33 one year after first child born symptoms became more problematic. Bloating, lower abdominal pain with every meal, seemed suddenly "allergic" to all kinds of food that had never bothered me before, continued hairloss long after postpartum time period, fatigue, depression, irritability, and the continuing D and C.

Just curious about how many out there have diagnosed celiac with 2.2/2.2, how many have gluten intolerance, and whether or not the severity of symptoms in either of those cases is linked to having the "lower-risk" genes.

Thanks!

Yup...I am the proud recipient of a double, dog dare DQ-2! :lol: I thought I had triggered in my late 20's (I am 51 now) because of the severe stomach pain I endured after eating but in retrospect, I may have triggered as a very young child. I always had stomach pain and discomfort and can remember being sick back to the age of 4. It came and went. I was also extremely pale and thin, compared to everyone else. Back in the 1960's, people did not drag their kids off to the doctors all the time and sought professional help when they were sick only. I am not sure Celiac would have been looked for in the early 60's, to be honest. I was diagnosed Celiac via blood work as I failed all the blood tests by huge numbers. I declined the biopsy because I was suffering from severe nausea all the time and couldn't deal with having a tube shoved down my throat.

My appendix nearly ruptured at the age of 8 and I had an emergency appendectomy. My intestinal tract was all inflamed but they blamed that on the bad appendix. My teen years were OK but that could have been my honeymoon phase of the disease. The other HUGE clue was I always took excellent care of my teeth yet I had horrible tooth and gum issues. The dentist was always so perplexed by this. My 2 center, lower teeth came in with no enamel on them, which I had to have capped. I was also painfully thin and many in high school thought I had an eating disorder. That really hurt because I have never had any kind of eating issues other than food caused me pain at times. I love to eat.

When I read books on Celiac Disease and saw just how many symptoms I had over the years, I was downright PO'd that it was missed for so long. I had almost every know symptom for it, except acid reflux. Mouth sores, neurological symptoms, failure to gain any weight ever...the list goes on and on. Along the way I developed Hashi's thyroid disease, Sjogren's Syndrome, Reynaud's

Syndrome and I still cannot digest lamb. All other meats are fine but I just cannot eat lamb.

I have read that those with a double DQ-2 or 8 will have the severest form of Celiac and that makes sense. Double trouble! I have successfully eradicated gluten from my diet and it literally was like a miracle cure. All symptoms gone and I have never felt better. So, now I have to be careful I don't offend people with my obnoxious anti-gluten stance because, from where I am standing, I think a boatload of folks I know have it and they don't want to go there! :ph34r:

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mari, 0302 is DQ8, the other main celiac gene, and 06* is DQ6 which is a subtype of DQ1.

Check the charts at the HLA DQ page on wikipedia.


gluten-free since may 06 after neg. biopsy symptoms went away and DH symptoms which I had since 03 got gradually better.

daughter officially diagnosed celiac and casein intolerant.

non-DQ2 or DQ8. Maybe DQ1? Updated: Yes, double DQ5

Hypothyroid since 2000, thyroxine first started to work well 06 on a low-carb and gluten-free diet

Lost 20 kg after going gluten-free and weighing 53 kg now. neg. biopsy for DH. Found out afterwards from this forum that it should have been taken during an outbreak but it was taken two weeks after. vitaminD was 57 nmol/l in may08)

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I was tested by Enterolab as having HLA-DQB1 0202 for both Allelle 1 and Allele 1, which indicates non-celiac gluten sensitivity.

When I was a kid, my legs would ache a lot in the evening. I was always asking my Dad for a leg rub. I didn't have problems with any foods, but I hated drinking milk, which my parents would force me to do.

I'm only 5'1", despite having several brothers well over 6' and many tall relatives. I definitely am the runt of the family. As an adult, I had some gas and bloating, but it didn't seem extraordinary to me. I had about 20 cavities by my 50s, even though I didn't eat much of anything that had sugar in it, nor drink any soda, nor eat much processed food. I thought I ate a very healthy diet, which included lots of homemade "healthy" whole grains.

I was diagnosed with osteoporosis in my late 50s, despite taking lots of supplements and exercising. My teeth are not very white - they look transparent at the tips. My fingernails have strong vertical ridges and the white at the tips is transparent where the ridges extend into the white area. As an adult, my feet, knees, elbows, and hands would ache a lot. I would get canker sores occasionally. I can drink my homemade kefir made from raw milk, but I get a lot of bloating from commercial milk.

I never did blood testing for celiac. After my osteoporosis diagnosis, I did the Enterolab stool gluten sensitivity panel. My Antitissue Transglutaminase IgA was 9, my antigliadin IgA was 8 (normal is <10 for both of those), my fecal fat was 94 (<300), so they said there was no direct evidence of gluten sensitivity. So I kept eating gluten, although I was concerned that my numbers were so close to the threshold for diagnosis. My B12 was low on a Spectracell test, and my blood tests stayed in range but showed low iron, low protein, low RBC, and high MCV.

Eight years after the stool test, in December 2011, I heard a radio show about genetic gluten testing and decided to eliminate the doubt I had about eating gluten once and for all. So now I have no doubt that I should not eat gluten. I never felt that bad before, but I haven't had any bloating since I stopped eating gluten over a month ago.

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