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TJ060306

Does These Results Seem Like Celiac?

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Hi all...

I went for a endoscopy in Oct due to trouble eating, once I ate something it felt like it was stuck in my throat. So I along with my GI went in thinking maybe GERD at most.Well once he was done he said he thought EE and gastritis he gave me meds and sent me on my way. Well soon after I had endo done I started having problems with constpitation, big D, and massive bloating feeling. In hinesight I should have maybe told him that I have had blood in my stools and they always float, I just thought it was because I dont eat healthy (I am 60 lbs overweight).

This is what his report right after the prodcedure (before any results)

The patient was kept NPO and prepared with intraventous fentanyl and Versed. The olympus scope was passed into her esophagus in the left lateral postion without any difficulty. She was found to have mild furrowing of the esophagus and some thickening of esophageal muscosa mostly in the upper esohagel area. Multiple esophageal biopies were taken to rule out eosinophilic esophagitis. She also had a small hitaus hernia and incompetent lower esophageal sphincter with free reflux. No evidence of Barrett's was seen. The stomach showed erosive antral gastritis. Biopsies were taken to rule out Helicobacter pylori and to rule out eosinophilic gastritis. Duodenal bulb showed acute duodenitis.

Then the biopsy report

Part 1: duodenal biopies: Duodenal mucosa with villious blunting and increased intraepitihelial lymphocytes

Note: Althought non specific, these findings may represent Celiac Diease. Clincal, endoscopic and serologic correlation advised.

Part 2: Gastric biopies: Mild to moderate chronic gastritis.

Note: No organisms suggestive of H. pylori seen on Alcian yellow stain.

Part 3: Esophageal biopies: Eosinophilic esophagtis.

Note: there are between 10-20 eosinophils per selected HPF. No intesinal metaplasia seen on H&E or Alcian blue stains.

So then when I went back for a month follow up he told me I only had EE and gastritis. That maybe I could have celiac but wait to the blood work comes back. If it comes back negative we will do a repeat endo in a couple of months. Well they did bloodwork which was negative and I did not go gluten free before the bloodwork but for the month before the blood I was so bloated that I didnt want to eat so I wasnt eating much.

Results of the bloodwork

Tissue transglutaminase antibody IGA: <3 (<5 negative, 5-8 equivocal, >8 postive

Immunoglobulin A: 133 (81-463)

Gliadin Antibody (IGA): 4 (<11 negative, 11-17 equivocal, >17 postive

So my question is, what do you think? I dont know what to think I would have never thought celiac disease before this but now I think I do. I should also mention for the past 2 years I have seen a rhemoy doc because of other issues. Which are iron defencity animena, hair loss, muscle/joint pain, and a slight postive ANA. I also am taken zolaft for anixety. Autoimmue dieases run in my family(all first genration girl cousins on maternal side all have autoimmune dieases).

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wow, im impressed- i love that your doc did his routine endoscopy and took biopsies of the small intestine... seems like some just skip that.

in my non-doctor opinion- i would assume you were a Celiac with a false negative blood test. that's just my opinion because of your symptoms & the villi blunting.

maybe now- you should experiment with a 100% gluten free diet to see if you improve :)


1986- Elevated Speckled ANA/no Lupus.negative Sjorgens

2008- AntiGliadin IGA/IGg~ Negative,TTG IGA/IGg~ Weak Positive, Endomysial Antibody~ Positive, IGA Deficient.

no biopsy (insurance denied)

6/2010- Enterolab Gene Test:

HLA-DQB1 Allele 1 0302

HLA-DQB1 Allele 2 0302

HLADQ 3,3 (subtype 8,8)

7/2010- 100% Gluten Free

8/2010- DH

10/2010-Hypothyroid dx-> 12/2010 Hashimoto's dx + 1/11- Graves dx :(

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Then the biopsy report

Part 1: duodenal biopies: Duodenal mucosa with villious blunting and increased intraepitihelial lymphocytes

Note: Althought non specific, these findings may represent Celiac Diease. Clincal, endoscopic and serologic correlation advised.

This could very easily be an early stage celiac biopsy. IEL alone can be seen in other inflammatory conditions but the blunting is very suspicious. Is the gluten-free diet giving you some relief? If so, you're probably celiac.

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wow, im impressed- i love that your doc did his routine endoscopy and took biopsies of the small intestine... seems like some just skip that.

in my non-doctor opinion- i would assume you were a Celiac with a false negative blood test. that's just my opinion because of your symptoms & the villi blunting.

maybe now- you should experiment with a 100% gluten free diet to see if you improve :)

Totaly agree!


Me:
Celiac disease(positive blood work/biopsy- 10/2008), gluten free oat intolerent, Hashimoto's Thyroiditis/Disease, Raynaud's Disease


DS2(age 9):
celiac disease(positive IgA tTG, no biopsy- 11/2010)


DS1(age 13):
repeated negative bloodwork and negative EGD/biopsy. Started on a gluten free trial(8/2011). He has decided to stay gluten free due to all of the improvements he has experienced on the diet.

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I was having a lot of your same symptoms. I went to the doctor about 2 years ago because it felt like something was stuck in my throat. I knew there wasn't, as I could still eat and drink and talk, but there was this strong pressure. That was my first endoscopy. They didn't find anything wrong, but recommended Opramazole as my anti-inflammatory meds were irritating my stomach. I have historically always had a high ANA and SED rate (for almost 26 years..I'm 42). That is why my regular doc sent me to the Rheumatologist about 2 1/2 years ago (along with an incredibly sore right pinky finger). I was having pain I thought was from my gallbladder (upper right abdominal). They did another endoscopy to rule our intestinal issues before they took out my gallbladder. It was during routine biopsy that they found my blunted villia...not damaged, just blunted. My doc ran the genetic panel, and since I was + for one of the genes, recommened the celiac diet. A month later, since I was feeling SOOO much better, he decided I had celiac. He never ran any other blood work. I am now totally off all medications. I think if I was in your shoes, I would just do the diet and see if I feel better. :D

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