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Michael & Rachel

Negative Iga Antibodies; Positive Iga - What Does This Mean?

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Hi!

I recently had the celiac panel blood test done after numerous other tests came back negative.

I keep getting mixed messages from doctors and have been gluten free for about 6 weeks.

It's still up and down and I'm wondering if I am, in fact celiac.

Any help interpreting these results would be greatly appreciated!

CRP My Result: <0.2 Reference Range: <8.0 mg/L

ANTINUCLEAR AB. (ANA) My Result: NEGATIVE Reference Range: NEGATIVE

GLIADIN IgA ANTIBODIES My Result: 2.3 Reference Range: <12 U/mL

GLIADIN IgG ANTIBODIES My Result: 34.7*** Reference Range: <12 U/mL

TRANSGLUTAMINASE IgA AB My Result: 3.2 Reference Range: <10 U/mL

EDIT: sorry about the topic title it's supposed to read "Negative IgA Antibodies; Positive IgG **

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Did your doctor run total IgA? if you're IgA deficient, which is common in celiacs, the IgA tests don't mean anything. Total IgA can be run gluten-free if you need to go back and have it done. Unfortunately, you would also need TTG IgG, which cannot be run gluten-free.

You also need to know whether the gliadin is the old anti-gliadin test or the newer deamidated gliadin. Deamidated gliadin IgG would definitely be celiac. The old anti-gliadin test can be positive in gluten intolerance too, especially IgG if you have normal levels of total IgA.

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Did your doctor run total IgA? if you're IgA deficient, which is common in celiacs, the IgA tests don't mean anything. Total IgA can be run gluten-free if you need to go back and have it done. Unfortunately, you would also need TTG IgG, which cannot be run gluten-free.

You also need to know whether the gliadin is the old anti-gliadin test or the newer deamidated gliadin. Deamidated gliadin IgG would definitely be celiac. The old anti-gliadin test can be positive in gluten intolerance too, especially IgG if you have normal levels of total IgA.

Thank you for your response and insight. My doctors are not very familiar with Celiac and they did not ask for my total IgA to be tested. They have also not been able to refer me to a true GI specialist.

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yes, get the total IgA done, and shame on the doctors or lab for not doing that one.

And, yes, ask if this was the new deamidated gliadin test. Several places just list them as gliadin Ab nowadays so one needs to ask.

In case of low or lowish total IgA, they always run the IgG versions of tests instead.

In any case, the high test is suspicious.

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