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Hi. For the past 6 years I've been having problems with low grade fever varing from 36.9 to 37.5 celcius, fatigue and brain fog. I've done many tests, all went back negative except EBV where my IGM and IGG antibodies were high. I was told that EBV with corelation of low ESR and negative CRP can't produce these symptoms. I gave up for a while but came across some articles about celiac and gluten intolerance and various symptoms that it may cause. I went for home gluten test from amazon but it came out negative. I've got celiac sister but she has anemia. Should I bother with digging this subject? Is it possible to have celiac or/and gluten intolerance with low esr, negative crp - which shows no inflammation in body?

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Hi. For the past 6 years I've been having problems with low grade fever varing from 36.9 to 37.5 celcius, fatigue and brain fog. I've done many tests, all went back negative except EBV where my IGM and IGG antibodies were high. I was told that EBV with corelation of low ESR and negative CRP can't produce these symptoms. I gave up for a while but came across some articles about celiac and gluten intolerance and various symptoms that it may cause. I went for home gluten test from amazon but it came out negative. I've got celiac sister but she has anemia. Should I bother with digging this subject? Is it possible to have celiac or/and gluten intolerance with low esr, negative crp - which shows no inflammation in body?

If your sister has celiac, there is a good chance you do too its inherited, genetic.

You should have a full celiac blood panel done. demediated IgA, IgA, IgG...etc.

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After you are done with testing the other poster mentioned and the endo if you choose to have one, give the diet a good strict try. It sounds like at this point a lot of your issues are neurological so you may have a higher likelyhood of a false negative.

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Thanks for the replies. There's no point in taking tests for me, cause I may risk loosing job. Just wanted to ask if that fits. I may easily take gluten free trial for month or two, but it would be easier for me if I knew that it makes sense. I am bit skinny (190cm - 70 kg) despite the fact that my diet is over 3000 calories a day. Still wondering, cause celiac is a disease that causes inflammation and my CPR was negative and I had low ESR.

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If you risk losing your job if you do testing, then be assured there is absolutely no risk in trialling gluten free. You do not need anyone's permission and no one need even know :o But hey, if it works, you will have got somewhere. If it doesn't, then there is no risk in resuming eating gluten. Nothing willl happen to you unless gluten is a problem, in which case you may start having symptoms you didn't have before.

If you have no GI symptoms, your body may not have the inflammation typically seen with those symptoms. If your symptoms are entirely neurological I am totally unsure about inflammation being necessarily present. But if you want to get rid of the fatigue and brain fog and they are being caused by gluten, you will need to trial the diet strictly for a good three months at least, because the neuro symptoms seem to be the slowest to resolve.

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Hi, I experience neurological symptoms so have been reading alot of M Hadjivassiliou's research on the neurological manifestations of celiac. He states that the IgG are better markers for celiac in neurological presentations so if yours are high, it could be indicative of celiac.

"IgG anti-gliadin antibodies have been the best diagnostic marker in the neurological population we have studied. IgG anti-gliadin antibodies have a very high sensitivity for celiac disease but they are said to lack specificity. In the context of a range of mucosal abnormalities and the concept of potential celiac disease, they may be the only available immunological marker for the whole range of gluten sensitivity of which celiac disease is only a part."

Excerpted from Gluten Sensitivity as a neurological illness

- M. Hadjivassiliou

http://jnnp.bmj.com/content/72/5/560.full

I agree with the other posters. Try going gluten free - you have nothing to lose!

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Thank you all. I am definitely gonna give gluten free diet a go.

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