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    Jefferson Adams
    Jefferson Adams

    By Jefferson Adams •

    Does Gluten Intake at the Time of Hepatitis B Vaccination Influence the Immune Response of Celiac Disease Patients?

    Reviewed and edited by a celiac disease expert.

    Celiac.com 06/07/2013 - A number of studies have indicated that people with celiac disease have an inadequate response to hepatitis B vaccination. In an effort to better understand the issue, a team of researchers recently set out to assess hepatitis B vaccination response in relation to gluten exposure status in patients with celiac disease.

    Photo: CC--alegryaThe research team included F. Zingone, P. Capone, R. Tortora, A. Rispo, F. Morisco, N. Caporaso, N. Imperatore, G. De Stefano, P. Iovino, and C. Ciacci. They are affiliated with the Department of Medicine and Surgery at the University of Salerno in Salerno, Italy.

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    To measure the gluten exposure status at the time of vaccination, they compare three groups of patients, along with a control group. In all, the study included 163 celiac patients.

    • Group A contained 57 patients exposed to gluten, including patients vaccinated as 12-year-old adolescents, for whom celiac disease diagnosis was established after vaccination.
    • Group B contained 46 patients not exposed to gluten, including patients vaccinated as 12-year-old adolescents and on a gluten-free diet at the time of vaccination.
    • Group C was composed of 60 infants, including those vaccinated at birth.
    • Group D included 48 healthy, vaccinated, non-celiac subjects.

    The researchers then compared the response of celiac patients to hepatitis B vaccination with the response by healthy subjects. They found that 43.9% of patients in group A, 34.8% of patients in group B, 58.3% of patients in group C, and 8.3% of patients in group D showed inadequate response to hepatitis B immunization.

    Overall, group A versus group D, P less than 0.001; group B versus group D, P = 0.002; group C versus group D, P = 0.001, while they found no significant difference for group A versus group B and group A versus group C.

    This study suggests that gluten exposure does not influence the response to hepatitis B immunization, and that the human leukocyte antigen likely plays the main immunological role in poor responses to hepatitis B-vaccinated celiac patients.

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    Guest Cristie

    Guest Cristie

    Posted

    What does poor response mean exactly? Like the vaccine doesn't work on some celiacs?

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    Guest Lynn_M

    Guest Lynn_M

    Posted

    58.3% of infants had an inadequate response to the hepatitis B vaccination, and yet it is standard protocol to give the hepatitis B shot at birth. This ineffectiveness is one more reason it's madness to give the shot to infants.

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    Guest Lisa
    58.3% of infants had an inadequate response to the hepatitis B vaccination, and yet it is standard protocol to give the hepatitis B shot at birth. This ineffectiveness is one more reason it's madness to give the shot to infants.

    I disagree. Over 40% of these infants had an adequate response and therefore would be protected if exposed to hepatitis B prior to future vaccinations. As always, it is important to assess risk vs. benefit when deciding about any vaccine for any individual, but the fact that only part of the population responded is not necessarily a reason to avoid/delay vaccination. If there is risk of exposure to hepatitis B, then it is likely better to protect some infants versus protecting none.

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     

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