Any Thoughts On These Results? Did They Include Everything?

[greenchick22]

I posted several days ago about my negative results and they came today.  I would love someone to explain them to me!

 

Celiac Panel 10

 

 

Test                        Result                             Flag                  Acceptable

 

TTG AB IGA              1.5 U/ml                          N                        <20

 

Gliadin Peptide AB IGG         10.1 U/ml            N                        <20

 

Gliadin Peptide AB IGA     2.1                          N                        <20

 

TTG AB IGG             10.6                                N                         <20

 

IGA                            106                                N                        69-380

 

Endomysial Screen - Negative

 

*There is a note at the bottom that in the case of negative results and still suspected Celiac, the total IGA should be measured to test for deficiency.  Could I possibly have that?  How does one know whether to pursue that?

 

Thanks so much!

 

[nvsmom]

That looks like a really comprehensive panel. The tTG's, DGP's and EMA tests are all for detecting intestinal damage (high levels cause it) and are the best tests for detecting celiac. 

 

I think the IgA listed on the lab was the total (serum) IgA. Immunoglobulin A is low in about 5% of celiacs so that is why they run it. If your IgA levels are normal, then you make adequate IgA for the actual celiac tests to be accurate. Yours is normal, albeit a bit on the low side, so your celiac tests (DGP, tTG, EMA) should be accurate.

 

The only tets not run was the anti-gliadin antibodies (AGA IgA and AGA IgG). It is an older test that is thought by some to show gliadin sensitivity in both celiacs and non-celiac gluten sensitive (NCGS) individuals. It does not have a perfect sensitivity though and can miss some people.

 

To me, it looks like you probably don't have celiac disease, but you could still have a gluten sensitivity that can produce all the same nasty symptoms as celiac disease does, minus the intestinal damage.

 

Are you planning on going gluten-free? Best wishes.

[GottaSki]

I posted several days ago about my negative results and they came today.  I would love someone to explain them to me!

 

Celiac Panel 10

 

 

Test                        Result                             Flag                  Acceptable

 

TTG AB IGA              1.5 U/ml                          N                        <20

 

Gliadin Peptide AB IGG         10.1 U/ml            N                        <20

 

Gliadin Peptide AB IGA     2.1                          N                        <20

 

TTG AB IGG             10.6                                N                         <20

 

IGA                            106                                N                        69-380

 

Endomysial Screen - Negative

 

*There is a note at the bottom that in the case of negative results and still suspected Celiac, the total IGA should be measured to test for deficiency.  Could I possibly have that?  How does one know whether to pursue that?

 

Thanks so much!

 

Had you removed gluten or eaten gluten light before the blood was drawn?

 

The tests are indeed all negative, but the one interesting item is your Total Serum IgA -- while it is not officially LOW - it is on the low end of normal which is common among myself, my children and grands....Only myself and my eldest child had tested marginally positive antibody tests with decades of unexplained illness.  Our endoscopic biopsies were all severe with complete villous atrophy.

 

If you or your doctors suspect Celiac Disease -- I would encourage either endoscopy and/or complete removal of gluten for three months (six is better) to monitor symptoms.  Do not remove until all testing is complete.  Once testing is complete -- elimination of gluten is the only test for Non Celiac Gluten Sensitivity (NCGS).

 

Good Luck to you

[greenchick22]

Thank you so much!  I was eating normally at the time.

 

Had you removed gluten or eaten gluten light before the blood was drawn?

 

The tests are indeed all negative, but the one interesting item is your Total Serum IgA -- while it is not officially LOW - it is on the low end of normal which is common among myself, my children and grands....Only myself and my eldest child had tested marginally positive antibody tests with decades of unexplained illness.  Our endoscopic biopsies were all severe with complete villous atrophy.

 

If you or your doctors suspect Celiac Disease -- I would encourage either endoscopy and/or complete removal of gluten for three months (six is better) to monitor symptoms.  Do not remove until all testing is complete.  Once testing is complete -- elimination of gluten is the only test for Non Celiac Gluten Sensitivity (NCGS).

 

Good Luck to you