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What Could Cause Elevated Igg And Iga In Toddler Other Then Celiac?

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My 21 month old goes in Tuesday for her second biopsy..first was neg..went on gluten challenge blood workd showed igg at over 100 and iga at 86...im nervous this biopsy would be neg too. Dr said if it was further testing would be in order..but what would they test for? what causes the elevation other then celiacs?

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My 21 month old goes in Tuesday for her second biopsy..first was neg..went on gluten challenge blood workd showed igg at over 100 and iga at 86...im nervous this biopsy would be neg too. Dr said if it was further testing would be in order..but what would they test for? what causes the elevation other then celiacs?

 

Are you talking about tTG-IgA and tTG-IgG -- i think you have answered this before, but if she has only had Tissue Transglutaminase antibody tests, then she should have the remaining celiac antibody tests run:

 

EMA-IgA

DGP-IgA

DGP-IgG

 

Good luck with the biopsies -- I hope they bring the answers needed for your family -- make sure the GI is going to take 6-8 samples of the small intestine -- since this is your second round it is important to be sure so you don't have to go through yet another challenge down the road.

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Thank you..im not sure exactly which the ran im hoping to go get the results today so I will post that info too....all they said over the phone was everything was super high positive, and another biopsy wasi n order, and if it was neg they would run more tests...so im just afraid if it is neg what else would they do? what do they test for with results like that other then celiac

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I don't have kids myself, but I know I read that it can be difficult to diagnose Celiac in children and it is not uncommon for the biopsy to come back negative simply because they haven't been alive long enough for the damage to be significant.  There is a section in the forums dedicated to kids and kid-specific issues that you may want to check out.

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The tTG IgA and IgG are pretty specific for celiac disease. The tTG IgA has a specificity of 91-99% as seen here: http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf The The tTG IgG has a specificity of about 95% as seen here: http://www.jfponline.com/index.php?id=22143&tx_ttnews[tt_news]=172034 This site also shows a higher specificity for the tTG IgA - This means that 5% of positives (or less) are caused by something other than celiac disease.

 

When false positives do occur, it is a weak false positive. After almost 2 years of reading, reasearch, and posting on here more than my housework shoul allow, and I have never seen high poisitives caused by anything other than celiac disease.  On the other hand, I have seen a few WEAK positives caused by thyroiditis, diabetes (T1), crohn's, colitis,chronic liver disease, and infections. I have hypothyroidism and I am guessing that is what causes my tTG IgA to remain slightly/weakly elevated (at 20 point something when the upper normal limit is 20 - when first diagnosed it was over 200).

 

I see she has a pretty high TSH which would indicate hypothyroidism/thyroiditis at some labs. That could elevate her tTG IgA minimally. I'm afraid that I don't know is it would affect the tTG iGG - I REALLY doubt it would push it over 100 in any case. It's celiac disease.  ;(

 

Are you pursuing her high TSH too? If so, a recheck of the TSH would be good (near a 1 is normal), free T4 and free T3 (should be in the 50-75% range of your lab's normal reference range), and TPO Ab are good to ask for.

 

Best wishes.

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