Still Trying To Get Diagnosed!

[SPinch03]

Hello everyone!  I'm back after a year of still no answers.  Finally seeing a new group of doctors since I recently got a new job.  My new primary doctor thinks I may have celiac and wants me to get another opinion.  Going to see the new gastroenterologist next week and I can't wait to go.  I'm hoping to finally get some answers to the issues I've been having.  Although it will be a huge lifestyle change I think I will be relieved to know that everything I'm feeling just isn't in my head.  Doctors are so quick to tell me all of my symptoms are stress-related.  Here is a little background about me!  

 

May of last year I started realizing I was loosing my eyebrows (Still haven't grown back!!) - initially thought it was my thyroid, all levels were within range though.  I'm also not loosing them on the outer corner of my eye but more towards the inner corner (Doesn't really matter I'm sure).  Tested my Iron and my ferritin was down to an 8 when in previous years it was around 200 something.  No bleeding episodes and my menstrual cycles are light.  I started  researching hashimoto's and iron deficiency and started seeing stuff about celiac. 

 

In the lab I work in I was tested for tTg IgG/IgA, Gliadin IgG/IgA and Total IgA.  I was not deficient in IgA and I'm not sure if the testing for gliadin was deaminated or not (don't believe it was).  I don't have my exact results for the tTg IgG/IgA or Gliadin IgA but I remember they were within normal limits, but my Gliadin IgG was 3.59IV and a positive was anything greater than of equal to 1.1.  

 

I also had the genetic test done and I was negative for HLA-DQB1*02 and HLA-DQB1*03:02 but I was positive for HLA-DQA1*05.  I know this isn't diagnostic in itself for celiac disease. 

 

I had a endoscopy and the report read as follows: 

A. Duodenal mucosal biopsies with no significant microscopic abnormality.  No diagnostic histology features of celiac are appreciated

B.  Gastric antral and oxytocin mucosal biopsies showing chronic gastritis.  Reactive foveolar hyperplasia is present.  H. pylori is negative

 

The material present is partly tangentially sectioned.  The villous crypt ratio is about 3.5.  There are intraepithelial lymphocytes but they don't seem to be significantly increase in most of the villi.  There are inflammatory cells in the lamina propria including plasma cells and lymphocytes with an occasional germinal center. They are normal to slightly increased in number.  No histologically diagnostic features of celiac are appreciated.

 

Really hoping this new gastro will shed some light on all of my questions...  Trying to eat as much gluten as I can tolerate before going for testing. I previously did not experience any GI symptoms but now I have been experiencing stomach pain (not everytime I ingest gluten but occasionally) The pain comes in waves, the pain builds up then subsides..I'm okay for a little while and then it happens again.  Keep your fingers crossed for me!!

 

 

[cyclinglady]

Keep us posted and I hope you find your answers!

[SPinch03]

Went to the new Dr. he was very nice and understanding and did say that I am at very high risk for developing celiac.  Had repeat blood work done (Waiting on results..) and he already scheduled me for an upper GI.  which I will have on September 1st.  *fingers crossed* that I get answers!  

[SPinch03]

Okay... so here goes all the new lab results:

 

Gliadin (deamidated) IgG:  4   normal <20

Gliadin (deamidated) IgA: 9    normal <20

tTg IgG: 3  Normal <9

tTg IgA: 1 Normal <4

 

Previous blood work I only tested positive for:

Gliadin (AGA) IgG  3.59 IV positive >/=  1.1 IV

 

GI still wants to perform the endoscopy even with the negative serologies.  Still says there is a possibility for the biopsy to be positive.  I'm preparing myself for a negative result tho, which still leaves me with no answers and an appointment with a rheumatologist next month.  I'm guessing something else is cross reacting and giving a false positive for the AGA IgG?  Anyone ever see these serologies with a positive biopsy?