Jump to content

  • You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

Blood work/Endoscopy

confusedbytest

Recommended Posts

confusedbytest Newbie
confusedbytest
Posted

Hey all--have Hashimoto's and am being worked up for epigastric discomfort and IBS like symptoms---

 

My blood work had an IgA within the lower end of normal range, negative TTG, but weakly positive DGP.

 

My endoscopy showed a "nodular" duodenum with the biopsy stating there was "reactive lymphoid hyperplasia"...

 

I have a follow-up with the GI in 3 weeks.

 

Wondering about any help?

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


confusedbytest Newbie
confusedbytest
Posted
  • Author

I should say I am confused about how to interpret---

 

Does this mean celiac or no celiac?

 

Thank you all---I greatly appreciate it.

ravenwoodglass Mentor
ravenwoodglass
Posted

While I am not a doctor it does sound like you are in the early stages of celiac. The DGP is quite specific to celiac and a positive is a positive. Keep eating gluten until after you see the GI then give the diet a good strict try for at least a couple months.

ironictruth Proficient
ironictruth
Posted
10 hours ago, confusedbytest said:

Hey all--have Hashimoto's and am being worked up for epigastric discomfort and IBS like symptoms---

 

My blood work had an IgA within the lowerend of normal range, negative TTG, but weakly positive DGP.

 

My endoscopy showed a "nodular" duodenum with the biopsy stating there was "reactive lymphoid hyperplasia"...

 

I have a follow-up with the GI in 3 weeks.

 

Wondering about any help?

Trust me, I have spoken to three US celiac research centers and one additional foreign expert and DGP is not that specific. Was it the IGA or IGG? Or does it not specify?

Here is one example:

Open Original Shared Link

That being said, it is still positive and can catch some folks with gluten problems (especially IGA deficient) so your bloodwork warrants getting the genetic test done. Was the EMA done? I was also recently informed by a researcher that the older gliadin (AGA) tests are useful in non celiac gluten sensitivity and  I think the research is still incredibly fuzzy about what happens if somebody with non celiac gluten sensitivity stays on gluten. I am going to try to get my AGA taken as well however the names that are used can be very similar and confusing to doctors when they order the labs and some Labs do not even use the AGA tests anymore. 

You will have to talk with your doctor about a diagnosis.  Do you know how many samples were taken for the biopsy in from where? And was             h-pylori rule that?

Best of luck and health. Keep us posted. 

 

confusedbytest Newbie
confusedbytest
Posted
  • Author

Thanks. 

 

I don't know how many biopsies and the only comment I have on my patient access portal is about the lymphoid hyperplasia and nothing about the crypts/villi being abnormal or normal.  

My H pylori was negative. 

 

 

 

 

 

 

 

 

Jmg Mentor
Jmg
Posted

Welcome :)

11 hours ago, confusedbytest said:

My endoscopy showed a "nodular" duodenum with the biopsy stating there was "reactive lymphoid hyperplasia"..

Had a quick google out of interest Open Original Shared Link:

Quote

The link between NLH and celiac disease seems to be rare[Open Original Shared Link,Open Original Shared Link]. It is important to underline that CVID patients may present small-bowel pathology similar to classic celiac sprue, known as “pseudo-celiac” pattern, with short villi, crypt hyperplasia, intraepithelial lymphocytosis, and, in some cases, an increase in apoptotic bodies in crypt epithelial cells. The diagnosis of CVID should be suspected when the number of plasma cells are reduced or absent in the lamina propria, and patients do not produce antibodies to tissue transglutaminase, endomysium, or gliadin. CVID patients typically do not respond to gluten withdrawal and do not express the genes associated with celiac disease, HLA-DQ2 and HLA-DQ8[Open Original Shared Link,Open Original Shared Link].

 Hopefully your GI consult can shed some further light. 

One suggestion. If your GI excludes celiac and you choose not to pursue further testing, give the gluten free diet a try in any case. It's possible you test negative but are still affected and avoiding gluten may still be the right course for you.  

I know this investigation phase is stressful and hard work. Best of luck, hope you get the answers you need.  

 

confusedbytest Newbie
confusedbytest
Posted
  • Author

Thanks---

 

Not sure what to think.  Appreciate all of your help.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      134,077
    • Most Online (within 30 mins)
      10,442
    terrificterry
    Newest Member
    terrificterry
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.7k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Who's Online (See full list)

  • Upcoming Events

  • Posts

    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      Sigh. I posted this yesterday based on the Safeway website. I went back again today to their website to double check. On the page where they are selling Vanilla Bean flavor, it has a distinct Certified Gluten Free label. Other flavors on the Safeway website didn't have the gluten-free statement. Today I went into the store. None of the flavors I looked at, including Vanilla Bean, have a Gluten Free statement. Is it safe? Who knows. The ingredients are either safe or nearly safe (some have "natural flavor"). There are warnings about "contains milk and soy" but not about wheat - this implies they are safe, but again, who knows. On the other hand, every flavor I checked of their Slow Churn line of ice creams has wheat as an ingredient. 100% not safe.
    • knitty kitty
      Edy's and Dreyer's ice cream

      By knitty kitty · Posted

      Do keep in mind that many of the newly diagnosed have lactose intolerance.  This is because the villi lining the intestinal tract are damaged, and can no longer make the enzyme lactAse which breaks down the milk sugar lactOse.  When the villi grow back (six months to two years), they can again produce the enzyme lactAse, and lactose intolerance is resolved.  However, some people (both those with and without Celiac Disease) are genetically programmed to stop producing lactase as they age.   Do be aware that many processed foods, including ice cream, use Microbial Transglutaminase, a food additive commonly called "meat glue," used to enhance texture and flavor.  This microbial transglutaminase has the same immunogenicity as tissue transglutaminase which the body produces in response to gluten in people with Celiac Disease.  Tissue Transglutaminase (tTg IgA) is measured to diagnose Celiac Disease in blood tests.  Microbial Transglutaminase acts the same as Tissue Transglutaminase, causing increased intestinal permeability and inflammation.   New findings show that microbial transglutaminase may be able to trigger Celiac Disease and other autoimmune and neurodegenerative diseases.   Microbial Transglutaminase is not required to be listed on ingredients labels as it's considered a processing aid, not an ingredient in the U.S.  Microbial Transglutaminase has been GRAS for many years, but that GRAS standing is being questioned more and more as the immunogenicity of microbial transglutaminase is being discovered. Interesting Reading:  Microbial Transglutaminase Is a Very Frequently Used Food Additive and Is a Potential Inducer of Autoimmune/Neurodegenerative Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC8537092/
    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      There is a 10 year old post in this forum on Edy's and Dreyer's ice cream. The information is somewhat outdated and the thread is closed to further comment, so here is a new one. Edy's And Dreyer's Grand Vanilla Bean Ice Cream - 1.5 Quart is labeled "Gluten Free". This is a different answer than years gone by. I don't know the answer for any other flavor at this moment. On 1 May, 2026, Edy's website says: "As a general rule, the gluten in Edy's and Dreyer's® frozen dessert products is present only in the added bakery products, such as cookies, cake or brownies. We always label the eight major food allergens on our package by their common name. We recommend to always check the label for the most current information before purchasing and/or consuming a product. The exception to this rule is our Slow Churned French Silk frozen dairy dessert, which contains gluten in the natural flavors." https://www.icecream.com/us/en/brands/edys-and-dreyers/faq It seems that Edy's and Dreyer's are more celiac-friendly than they were 10 years ago. Once I found enough information to make today's buying decision, I stopped researching.
    • Aretaeus Cappadocia
      EDG 3 years ago fine, now it shows focal villous blunting,

      By Aretaeus Cappadocia · Posted

      probably not your situation @Mimiof2, but allow me to add one more to @trents list of celiac-mimics: "olmesartan-induced sprue-like enteropathy"  
    • knitty kitty
      Terrible Neurological Symptoms

      By knitty kitty · Posted

      My dad had an Abdominal Aortic Aneurysm.  Fortunately, it was discovered during an exam.  The doctor could feel my dad's heart beating in his stomach/abdomen.  The aneurysm burst when the doctor first touched it in surgery.  Since he was already hooked up to the bypass machine, my dad survived ten more years.  Close call! Triple A's can press on the nerves in the spinal cord causing leg pain.  I'm wondering if bowing the head might have increased the pressure on an aneurysm and then the nerves.   https://gulfcoastsurgeons.com/understanding-abdominal-aortic-aneurysm-symptoms-and-causes/ Abdominal Aortic Aneurysm Presenting as a Claudication https://pmc.ncbi.nlm.nih.gov/articles/PMC4040638/
×
×
  • Create New...