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Will antihistamines affect DH?


Karwei5

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Karwei5 Apprentice

I am asking about my son who had celiac and Down syndrome.  He has had a rash we have been trying to control for 2-3 months. Doctor at first thought it was eczema,  the steroid cream did very little to help it.  I changed his soaps to dove. still very little  relief. Then I tried an otc antihistamine and that did reduce the itchiness and spots. After 10 days I took him off of the antihistamines but the rash/spots came back. It is hard to get hi into a dermatologist right now.  If it was dh, would an antihistamine affect it? I dont know how he would have been glistened. He has been home since the middle of march. it could be possible though... 


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cyclinglady Grand Master

Hi, I do not have DH, but I do have celiac disease.  Celiac disease can cause many rashes.  The worst is DH.  If the rash resolved with antihistamines (or at least the itch went away, it might just be hives.  I have had bouts of autoimmune hives which started with a gluten exposure.  My allergist thought they were more related to my autoimmune thyroiditis and my GI thought they were due to my celiac disease.  In any case, it was autoimmune related, that is for sure.  

I took antihistamines for daily for six months until my hives resolved.  I had no hives every morning, but by afternoon I was covered from head to toe.  The itching was pretty awful, but the antihistamines really helped.  

If he does have DH, a super strict gluten-free diet seems to help the most.  That means avoiding most processed food, even certified gluten-free foods.   Avoiding foods with iodine is also critical.    You can browse through the DH section for tips.  Dapsone is the only medication that helps DH, but it has some serious side effects.  

I hope he feels better soon!  

MisterSeth Enthusiast

wash his clothes and bedding in hot water with a little bleach. (the hottest setting on your machine)

if that helps it tells you he's allergic to dust mites or pet dander. 

if it doesn't help read the fabric tags looking for wool/fleece specifically. allergies to fabrics aren't unheard of

detergents are also a possible culprit

I went through this exact same thing a few years back, it was dust mites, i rolled up a sheet, stuffed it in a closet, and then later used it without washing it first. the correlation was not apparent to me until after they did the test and confirmed i have a dust mite allergy

Posterboy Mentor
On 5/26/2020 at 9:54 PM, Karwei5 said:

I am asking about my son who had celiac and Down syndrome.  He has had a rash we have been trying to control for 2-3 months. Doctor at first thought it was eczema,  the steroid cream did very little to help it.  I changed his soaps to dove. still very little  relief. Then I tried an otc antihistamine and that did reduce the itchiness and spots. After 10 days I took him off of the antihistamines but the rash/spots came back. It is hard to get hi into a dermatologist right now.  If it was dh, would an antihistamine affect it? I dont know how he would have been glistened. He has been home since the middle of march. it could be possible though... 

Karwei5,

You might try some Niacinamide....it has been shown to help some DH sufferer's...not sure if it will work in your son's case...

Here is a study about it....

 https://pubmed.ncbi.nlm.nih.gov/30390734/

I am in the middle of hay season so I might not answer right away....

Here is another thread from the DH forum that might help you....

https://www.celiac.com/forums/topic/114082-at-my-wits-end-with-this-rash/

Make sure it is the Niacinamide form....the non flushing form of Niacin....

Do not give your son Niacin.....without trying it yourself first .....because it will cause flushing....but can help itching....

Here is an article about Niacin and how to use it for antihistamine related seasonal allergies...

http://getwellstaywellathome.com/blog/2015/06/seasonal-allergies-and-the-niacin-flush/

Niacinamide is a B-Vitamin and should be taken 2/day for best effect or with every meal (if that is more convenient)  ....

Niacinamide is the form is that does not flush....try it first....but be patient....it can take up to a month to notice  significant improvement....and up to 3 months to notice a sustained difference....

I hope this helps your son.

I hope this is helpful but it is not medical advise.

Posterboy,

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    • trents
      Looks like from your spellings ("coeliac"), expressions ("bloods" for blood tests) and the lack of timely communication and appointment availability that you must be in the UK. It must be very frustrating to have to deal with such a dysfunctional healthcare system. I hope I haven't offended you. In the UK and in Europe in general, there is trend for doctors to grant a celiac diagnosis when ttg-iga scores reach 10x normal. Your daughter's scores certainly meet that criteria. I am not guaranteeing that will prove to be the case in your situation as I don't think that is yet a universal protocol even in the UK and in Europe. Some doctors may still insist on doing a scoping with biopsy to confirm the celiac blood antibody test results before granting an official celiac diagnosis. Beginning a gluten free diet now would risk sabotaging the results of the biopsy. There are also government benefits/stipends available in some areas of the UK to offset the cost of gluten free food and also some additional follow-up care if there is an official diagnosis.  
    • MTAC
      My daughter had been complaining of stomach paints intermittently for a while now. We had been to the doctors before in which they said it was just general constipation. For a good while its just been something she complained of and we would put it down to maybe its hunger pains because she is fussy with food, growing pains etc. - She was getting nose bleeds quite regularly and doctors just said she should have her nostrils cuarterized at some point (has had them here and there since a baby - but dad had the same when young so didn't question) Only recently we went to the doctors for tummy pain again and they requested FBC and a coeliac test.  The bloods come back with basically abnormal everything,  lots of lows, high platelets, ferritin, iron level of 2 ug/L  when the range should be 10.3 - 55.8. I was simply told she was anaemic and to take iron - coeliac result apparently hadn't come back at this stage and no follow up from drs.  I called a month later to ask for a copy of her blood test results so I could keep them for my own records, the receptionist of the surgery sent them over and included the coeliac testing results ( I had never heard of them coming back with no update etc)  he results stated - Tissue transglutaminase IgA level (XaJg2) Above range > 250.0 U/mL [0.0 - 15.0]. -  I am STRESSED. I googled a lot and come to terms with maybe they hadn't got in contact because they don't want you to change their diet until further testing had been done? and I was awaiting a paediatric referral.  I then made a doctors appointment for a separate issue (UTI) and upon attending the surgery the nurse mentioned the results briefly (baring in mind this is the first time I would have been made aware of the results) and said because the levels are so high I need to change her diet immediately. I was sent away with no more information but that. I requested a call from the doctor to discuss the results and they said it will take 6-8 weeks for a call back. I find a lot of contradicting advice online and in all honestly I don't know what to do. - Don't stop gluten until further testing done, levels being high so I need to stop immediately. As of late I had cut a lot of processed food/sugars out of our diets and my daughters meals were - 3/4 Weetabix of a morning - cheese crackers for lunch. Who knew I was poisoning her with this food at the time? But ever since I had started on these foods she had'nt complained of a stomach ache once. No other symptoms - she is full of energy, long hair, overall healthy but she is a small frame. I did wonder if she was lacking iron as she had darker undereye but I am also anaemic. I can't help but think of the worse.  - I have another daughter 15 months younger and have requested her to be tested also as what it states on NHS is recommended - Whether they get back to me will be the next hurdle. My plan is to remove gluten from our household completely.  Myself, partner and other daughter can eat it if out of the house but nothing to be had at home with it in. (Of course I would not sit in front of my daughter diagnosed and eat something she can't have). Although I'm hoping to test us all just to clarify further. I don't know where I am going with this, I'm not sure what to do next, is there any further testing I should request or any other things I should be thinking of? At this stage I feel lost with no support and no guidance on what to do now.        
    • trents
      I do not think that foregoing the biopsy when the ttg-iga is 10x normal has yet been adopted as a universal protocol in the U.S. We are not quite as far along on that one as they are in Europe I believe. One option is to trial a gluten free diet and then attempt a "gluten challenge" later on if for some reason it becomes important to distinguish between having celiac disease and NCGS (Non Celiac Gluten Sensitivity). Although, it is often the case that once you have been gluten free for a significant period, returning to gluten brings more violent reactions. Immunoglobulin A, Qn, Serum is not a test for celiac disease for celiac per se but is a test for IGA deficiency. If someone is IGA deficient, IGA test scores will be artificially low and cannot be trusted. Your daughter is not IGA deficient. Yes, the EMA doesn't get a score apart from being just positive or negative. Unless your daughter is a super sensitive celiac, the biggest challenges will not be keeping her safe in the home but rather away from home. Eating out is the biggest challenge to celiacs because you have not much control over how food is handled back in the kitchen. You can order naturally free gluten free foods but it may be cooked in pots and pans and on grills that are also being used for wheated things. This may be helpful, though some suggest measures in this article may be overkill unless you are super sensitive:   
    • lizzie42
      Thank you! That's so encouraging. We are planning to go 100 percent gluten-free at home apart from continuing to feed the other kids gluten till they get their tests. I assume that if you have zero gluten in the kitchen eventually cross contamination ends! It does seem overwhelming at first!    Once they've been gluten free for awhile is it obvious when they get exposed on accident? She's improved a lot in the last few weeks even on gluten since doubling her iron dose. Her ferritin has come up so I assume that's why. But she still has the huge meltdowns some days and it makes sense now. 
    • Jsingh
      Hi, I am mother of a six year old who was organized a year ago when she was fine.    to answer your question about removing gluten from your kitchen- it will be a mammoth task but your entire kitchen has to be free of gluten for her to be safe. Now I’ve learnt from this forum and others that different celiac patients show different level sensitivities to exposure to gluten. My daughter is extremely sensitive. And her sensitivities have only gone up in the months since the diagnosis. if there is anything that I can tell you from my experience for sure is that there is a learning curve no matter how careful are. It’s still a process for us- and to think of it that that after seeing her change as a person within three days of changing her diet I thought the job was done. I was so wrong.    We opted for no biopsy because the new guidelines in the US follows the European guidelines of no biopsy necessary in children if numbers are greater than 10 times the Normal among with other two positive tests. My daughters number were also greater then 100 and they also had EMA done.  My beast wishes to you. I will not lie it’s not hard to take care of a kid with celiac, but once she goes gluten-free and you see your child flourish despite the ups and downs of contamination here and there, it’ll give you enough strength. 
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