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Club fingers


catharine westlake

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catharine westlake Newbie

Can club fingers be a symptom of coeliac disease?


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plumbago Experienced

In terms of the clubbing shape, how it happens is actually a complex process. But usually nail clubbing occurs as a result of deficiency of oxygen to the body's tissues.

knitty kitty Grand Master

Welcome to the forum, @catharine westlake!

Yes, hypoxia (not getting enough oxygen) can cause clubbing in the fingers.  

Hypoxia can occur in subclinical Thiamine deficiency.  Thiamine Vitamin B 1 is needed to help carry oxygen around the body.  If one is low in Thiamine clubbing can result.  

My fingers showed clubbing when I experienced Thiamine deficiency, but they have returned to normal after supplementing with Thiamine in the form called Benfotiamine.  

Celiac Disease causes damage to the small intestine where essential vitamins and minerals are absorbed.  Nutritional deficiencies can result, and, unfortunately, can easily be overlooked or attributed to other symptoms.  Thiamine Vitamin B 1 simply runs out first, but do get checked for other deficiencies in B12 and Folate, too.

Ask for an Erythrocyte Transketolase test which tests for how well Thiamine is being utilized in the body.  

Hope this helps!

Thiamine deficiency disorders: a clinical perspective

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451766/

trents Grand Master

Yes. 

"Other conditions related to digital clubbing

Ascariasis. A roundworm infection of your intestines.

Celiac disease. An autoimmune disease that can damage your small intestine." https://my.clevelandclinic.org/health/diseases/23957-clubbed-fingers

captaincrab55 Collaborator

Here's a general reply to a simple search that includes Celiac Disease:  

People also ask

What is Club fingers a symptom of?

Clubbed fingers is a symptom of disease, often of the heart or lungs which cause chronically low blood levels of oxygen. Diseases which cause malabsorption, such as cystic fibrosis or celiac disease can also cause clubbing. Clubbing may result from chronic low blood-oxygen levels

Scott Adams Grand Master

Clubbing of the fingers is not typically associated with celiac disease. Clubbing of the fingers is more commonly associated with certain respiratory and cardiovascular conditions.

knitty kitty Grand Master
(edited)

"While clubbing is associated with many pathologies, it may also be observed with malnutrition, chronic alcohol use disorder, and chronic laxative use, often seen in individuals with eating disorders."

Nutritional Assessment

https://www.ncbi.nlm.nih.gov/books/NBK580496/?report=reader

 

"Review of the literature indicates that between 75 and 80% of cases are associated with chronic pulmonary diseases; 10 to 15% are associated with cardiovascular diseases; 5 to 10% with chronic hepatic and gastrointestinal disorders; and 5 to 10% with miscellaneous disorders."

https://www.ncbi.nlm.nih.gov/books/NBK366/

And...

https://www.mountsinai.org/health-library/symptoms/clubbing-of-the-fingers-or-toes

And...

https://www.researchgate.net/publication/340070700_ATYPICAL_CELIAC_DISEASE_PRESENTING_WITH_CLUBBING

"In our case, there were impairment of finger and iron

deficiency anemia which did not improve with replacement.

After the diagnosis of atypical celiac disease, a gluten-free diet

was started and symptoms rapidly regressed."

Edited by knitty kitty
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Wheatwacked Veteran

     Kwashiorkor.   protein deficiency.  Around 1969 the Biafran Relief Society was convinced to buy the modern wheat; developed by Norman Borlaug (who recieved the Nobel Prize in 1970); instead of the rice flour they had been buying.  Shortly afterwards we started seeing newspaper images of the famine in Biafra, now Nigeria. It was attributed to protein deficiency Kwashiorkor.  It would not be good to blame the wheat with a Nobel Prize at stake.     In 1976 when my just weaned infant son looked like this I recognized the image.  He was diagnosed with Celiac Disease after several biopsies.  A few months of Nutramigen followed by gluten free diet when weaned and he grew up healthy and strong.

BiafraBaby.webp.4cbf802b23e4f87ef6db3956eadeb9df.webp

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    • knitty kitty
      @glucel,  There's a strong correlation between thiamine deficiency, hypoxia, and insomnia.  Thiamine is needed to help red blood cells carry oxygen.  In thiamine deficiency, hypoxia (lack of oxygen in tissues) occurs, and this can result in insomnia. Hypoxia causes systemic inflammation, increases inflammatory markers, and is associated with cardiovascular events.  Curiously, thiamine deficiency is correlated with excessive daytime sleepiness and oversleeping.   I found a combination of Tryptophan, Pyridoxine B 6, magnesium, and L-theanine works very well for inducing sleep.  Sometimes, I add Passion Flower Extract and/or Sweet Melissa.  There's no side effects the next morning with Passion Flower, it just induces sleepiness.  Sweet Melissa is groovy, and has anti-inflammatory effects on the digestive system.   I prefer to take 250 mg Benfotiamine and 100 mg Thiamine TTFD in the mornings and another dose of Benfotiamine at lunch.  I try not to take any thiamine after four p.m. because it keeps my brain so energized and wanting to think... Oh, I do take a combination of another form of thiamine (sulbutiamine), Pyridoxine and Cobalamine for a pain reliever sometimes, but I can sleep after taking that.  But thiamine does help regulate circadian rhythm.   Make sure you're getting Omega Three fats! They'll help you satisfy that late night carb craving with fewer carbs.  Flaxseed oil, olive oil, sunflower seed oil.  Nuts and nut butters, like walnuts and cashews, are good, too, if you can tolerate them.    Try taking the 100mg thiamine HCl before your aerobics and see if there's a difference.  Sweet dreams! References: Network Pharmacology Analysis of the Potential Pharmacological Mechanism of a Sleep Cocktail. ......(Skip to Section Four) https://pmc.ncbi.nlm.nih.gov/articles/PMC11201840/ Effects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study https://pubmed.ncbi.nlm.nih.gov/39683592/
    • glucel
      Thanks to everybody for your help. I reread the dr's notes from the biopsy procedure and it seems I had worse than atrofied villi. It was termed flattened mucosa. So while iron ferratin levels are normal my bet is, as kitty alluded to, iron not getting into cells. I have dr appointment next mo but don't hold out a lot of hope, There is strong correlation of low red blood cells and insomnia so at least I finally solved that one after few yrs of being mislead. I intend to take stop taking 100 mg b1 at noon time and start 150 mg benfotiamin. I may or may not add the the 100 mg b1evening meal. BTW, last night had 1/3 lb beef. potato then 2 bowls cereal and an apple later in the eve. I generally do my areobics before supper so maybe that contributes to the hunger.  
    • knitty kitty
      I have osteoporosis and have crushed three vertebrae.  I supplement with Lysine, Tryptophan, threonine, calcium, Boron, Vitamins D, A, and K, and the B vitamins (folate, B12, and Thiamine B1 especially for bone health).   I tried Fosomax, but it tore up my insides.  I prefer the supplements.  I feel better and my bones feel stronger.   References: A composite protein enriched with threonine, lysine, and tryptophan improves osteoporosis by modulating the composition and metabolism of the gut microbiota https://pubmed.ncbi.nlm.nih.gov/41915427/
    • knitty kitty
      @Aileen Cregan, I was put on high blood pressure medication, too. But I was able to correct my high blood pressure by supplementing with Thiamine Vitamin B 1.  I am no longer on high blood pressure medication.  I feel much better without the medication. I continue to supplement Thiamine in the form Benfotiamine.   The particular high blood pressure medication I took was Norvasc (amlodipine), which causes thiamine deficiency by blocking thiamine transporters so that thiamine cannot enter cells.  Benfotiamine can get into cells by merging with the cell membrane, thus bypassing nonfunctional thiamine transporters.   Indapamide also blocks thiamine transporters! The use of this type of medications that block thiamine precipitated Wernickes Encephalopathy.  My doctors did not recognize the connection to Thiamine deficiency.  I nearly died.   Talk to your doctor and dietician about supplementing with Benfotiamine, a fat soluble form of thiamine that bypasses thiamine transporters.  Ask for an Erythrocyte Transketolace Activity Assay to check your thiamine levels asap.  Routine blood tests for thiamine are not an accurate measure of  thiamine in the body.   Absorption of essential vitamins like Thiamine is altered in Celiac Disease due to damaged villi, inflammation and dysbiosis.  The Gluten Free diet can be lacking in vitamins and minerals.  Discuss supplementing with all the eight B vitamins,  the four fat soluble vitamins and necessary minerals. Please keep us posted on your progress! References: Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3) https://pubmed.ncbi.nlm.nih.gov/31764942/ The Pivotal Role of Thiamine Supplementation in Counteracting Cardiometabolic Dysfunctions Associated with Thiamine Deficiency https://pmc.ncbi.nlm.nih.gov/articles/PMC11988323/
    • knitty kitty
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