Celiac.com Sponsor (A1):


Join eNewsletter


Celiac.com Sponsor (A1-m):



Join eNewsletter

Archived

This topic is now archived and is closed to further replies.

DonnaD55

How Reliable Is A Blood Test?

Recommended Posts

My daughter who is 12 has been dealing with abdominal cramping and diarrhea for about a year and a half. At first we thought it was lactose intolerance as taking her off of dairy helped a lot but not completely. We've rather loosely done a gluten free diet recently and she was better. But sometimes she can eat wheat products with no problems at all. She had a blood test for celiac last week and the test came back positive. Can i trust that it's correct or do we need more testing to confirm the diagnosis?

Share this post


Link to post
Share on other sites

Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8):


Hi and welcome. There are multiple tests for celiac disease, some of which are more specific than others. Which test was positive?

It is possible for someone with celiac to eat wheat without immediate symptoms. The autoimmune damage is still being done. She also may find that she gets more sensitive to wheat once you get the diet going correctly and her immune system settles down from the constant assault.

Share this post


Link to post
Share on other sites

http://americanceliac.org/celiac-disease/diagnosis/

One negative aspect of the TTG antibody is that it can be falsely positive in a patient who has another autoimmune condition. TTG false positivity has been described in patients with both type I diabetes and autoimmune hepatitis. Theoretically, it can also be falsely positive in other autoimmune disease.


Neroli

"Everything that can be counted does not necessarily count; everything that counts cannot necessarily be counted." - Albert Einstein

"Life is not weathering the storm; it is learning to dance in the rain"

"Whatever the question, the answer is always chocolate." Nigella Lawson

------------

Caffeine free 1973

Lactose free 1990

(Mis)diagnosed IBS, fibromyalgia '80's and '90's

Diagnosed psoriatic arthritis 2004

Self-diagnosed gluten intolerant, gluten-free Nov. 2007

Soy free March 2008

Nightshade free Feb 2009

Citric acid free June 2009

Potato starch free July 2009

(Totally) corn free Nov. 2009

Legume free March 2010

Now tolerant of lactose

Celiac.com - Celiac Disease Board Moderator

Share this post


Link to post
Share on other sites

Correct me if I'm wrong, but I've never heard of a false positive for a Celiac blood test. False negatives abound, but not false positives.

The blood tests that really leave no question are anti-EMA and anti-DGP. The old anti-gliadin test is notoriously inaccurate, although if you get a positive result you probably do need to have a biopsy and try the diet.

TTG is a sign of autoimmunity but not specific for celiac as Raven mentioned. As well as type 1 diabetes and autoimmune hepatitis, TTG is common in inflammatory bowel disease like Crohn's.

Share this post


Link to post
Share on other sites

Thank you so much for your thoughts. We go to the doctor on Tuesday to discuss the results of the test. I'll find out exactly what the test was. Meanwhile, we'll stay gluten free!

Share this post


Link to post
Share on other sites

Thank you so much for your thoughts. We go to the doctor on Tuesday to discuss the results of the test. I'll find out exactly what the test was. Meanwhile, we'll stay gluten free!

Get a COPY of the results. You will need them in coming years and she will need them as an adult.

Share this post


Link to post
Share on other sites

Thank you so much for your thoughts. We go to the doctor on Tuesday to discuss the results of the test. I'll find out exactly what the test was. Meanwhile, we'll stay gluten free!

If you are going to be referred to a GI you may want to continue eating a full gluten diet because he will probably want to do an endoscopy with biopsy to confirm the diagnosis, which requires a full gluten diet for acccurate results.


Neroli

"Everything that can be counted does not necessarily count; everything that counts cannot necessarily be counted." - Albert Einstein

"Life is not weathering the storm; it is learning to dance in the rain"

"Whatever the question, the answer is always chocolate." Nigella Lawson

------------

Caffeine free 1973

Lactose free 1990

(Mis)diagnosed IBS, fibromyalgia '80's and '90's

Diagnosed psoriatic arthritis 2004

Self-diagnosed gluten intolerant, gluten-free Nov. 2007

Soy free March 2008

Nightshade free Feb 2009

Citric acid free June 2009

Potato starch free July 2009

(Totally) corn free Nov. 2009

Legume free March 2010

Now tolerant of lactose

Celiac.com - Celiac Disease Board Moderator

Share this post


Link to post
Share on other sites

My daughter had tons of symptoms and yet her bloodwork came back negative. She did have the two genes for Celiac (forgot which ones) and both her dad and I tested positive for celiac disease. So, even though her tests came back negative she wanted to try the diet to see if it helped with her GI issues. A few weeks later she was right as rain! :D So, sometimes test results can be wacky, but listening to how your body responds is always a good way to go!


Diagnosed with Lymphoma March 2010. After surgery doctors said "Oops!"

Diagnosed with Celiac Disease April 2010. After endoscopy doc said "Aren't you glad?"

Uhhh.....yeah!

DD #1 ('99) tested negative on bloodwork but positive on 2 genetic markers. Went gluten free in July 2010 and has been symptom-free ever since!

DD #2 ('98) tested negative and has no symptoms. Didn't fork out money for genetic testing. Will watch and test regularly.

Husband tested positive in July 2010 and has refused to go gluten free. Uh huh, that's gonna bite him in the a** one day! (Pun intended!)

Share this post


Link to post
Share on other sites