Jump to content

  • You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

Help with IgA

Jeffb

Recommended Posts

Jeffb Newbie
Jeffb
Posted

I have been having constant nausea and vommitting for years and it seems to be progressively getting worse over the last few months. My doctor sent me for blood work and my tissue transglutaminase IgA results were 89.4 and the reference range is 0.0-20.0 and I'm not exactly sure what this means I know that's extremely high but does that confirm I have celiac disease. I also have been diagnosed with diverticulosis can that be a link to celiac disease anybody that could help me understand why I am feeling this way and what these results mean would be greatly appreciated it is interfering with my life and have been off work a lot in the last few months with these sypmtoms

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


mushroom Proficient
mushroom
Posted

Hi and welcome.

Your tTG score is very definitely elevated. Did the doctor run any of the other celiac tests and does he plan to send you to a GI for an endoscopy with biopsy to confirm the results as celiac disease? While that is the most likely cause, there are other things that can cause an elevated tTG. As for the diverticulosis, that can be present with or without celiac disease. It is generally caused by a low fiber diet and/or excessive constipation and the latter, of course, is often associated with celiac.

Jeffb Newbie
Jeffb
Posted
  • Author

My doctor is trying to get me into a GI specialist and he has put me zofran to try an control the nausea but all it has seemed to do is increase my diarhea and give me an extreme headache. It hasn't really reduced the nausea but based on the IgA results it is probably a good bet that I have celiac disease? Any suggestions on how to control the nausea and get back to a semi normal life? This is really frustrating and has been debilitating since last Wednesday and doesn't seem to be letting up. I am also experiencing extreme fatigue for the last week I have pretty much slept all day and then all night and always seem to be tired.

Skylark Collaborator
Skylark
Posted

Hi and welcome to the board. You're sure in the right place.

TTG is an autoimmune test, most commonly caused by celiac. It can also be caused by inflammatory bowel diseases so your Dr. will usually tell you to keep eating gluten (celiac testing does NOT work gluten-free) and send you to a GI. If you can't get to a specialist quickly, you might be able to work with your Dr. to get the follow-up celiac blood testing instead of a referral. You'd need anti-endomysial IgA (also called anti-EMA) and anti-deamidated gliadin peptide IgG and IgA. Those tests are specific for celiac.

If the specific celiac tests come back positive you could opt to forgo a GI visit and endoscopy and start on the gluten-free diet. If you have more than one positive blood test and improve off gluten it's reasonably certain you're celiac even without the biopsy "gold standard" diagnosis. It might get you back on your feet a little faster.

Jeffb Newbie
Jeffb
Posted
  • Author

Thank you all for the information have an an appointment in 2 hours and will ask about the follow up blood work. They said that my GI referral was sent may June last year and will take about a year to get in so I would be looking at another 2-3 months before I get in and can't wait that long to get back on my feet. Will post again after I see my doctor this afternoon to get more opinions. Again thank you all for the informative feedback.

ravenwoodglass Mentor
ravenwoodglass
Posted

While it may not be the case for all my diverticulosis was a direct result of celiac. Before I was diagnosed I had diverticuli throughout my entire large intestine. It was the most extensive case my GI had ever seen. When I had another colonoscopy done 5 years after diagnosis the diverticuli were almost completely resolved.

As was mentioned do stay on gluten until all celiac related testing is done then do give the diet a good strict try no matter what the other test results are.

cassP Contributor
cassP
Posted

dont know what ur diet is right now- but a little fyi- zofran has gluten in it... which makes me so ANGRY.. cause zofran totally helps with nausea. well, i only had the kind thru the IV which did not contain gluten and it worked fairly quickly.. was so sad to find the prescription had gluten :(

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      134,084
    • Most Online (within 30 mins)
      10,442
    Melvac
    Newest Member
    Melvac
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.7k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Who's Online (See full list)

    • There are no registered users currently online

  • Upcoming Events

  • Posts

    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      Sigh. I posted this yesterday based on the Safeway website. I went back again today to their website to double check. On the page where they are selling Vanilla Bean flavor, it has a distinct Certified Gluten Free label. Other flavors on the Safeway website didn't have the gluten-free statement. Today I went into the store. None of the flavors I looked at, including Vanilla Bean, have a Gluten Free statement. Is it safe? Who knows. The ingredients are either safe or nearly safe (some have "natural flavor"). There are warnings about "contains milk and soy" but not about wheat - this implies they are safe, but again, who knows. On the other hand, every flavor I checked of their Slow Churn line of ice creams has wheat as an ingredient. 100% not safe.
    • knitty kitty
      Edy's and Dreyer's ice cream

      By knitty kitty · Posted

      Do keep in mind that many of the newly diagnosed have lactose intolerance.  This is because the villi lining the intestinal tract are damaged, and can no longer make the enzyme lactAse which breaks down the milk sugar lactOse.  When the villi grow back (six months to two years), they can again produce the enzyme lactAse, and lactose intolerance is resolved.  However, some people (both those with and without Celiac Disease) are genetically programmed to stop producing lactase as they age.   Do be aware that many processed foods, including ice cream, use Microbial Transglutaminase, a food additive commonly called "meat glue," used to enhance texture and flavor.  This microbial transglutaminase has the same immunogenicity as tissue transglutaminase which the body produces in response to gluten in people with Celiac Disease.  Tissue Transglutaminase (tTg IgA) is measured to diagnose Celiac Disease in blood tests.  Microbial Transglutaminase acts the same as Tissue Transglutaminase, causing increased intestinal permeability and inflammation.   New findings show that microbial transglutaminase may be able to trigger Celiac Disease and other autoimmune and neurodegenerative diseases.   Microbial Transglutaminase is not required to be listed on ingredients labels as it's considered a processing aid, not an ingredient in the U.S.  Microbial Transglutaminase has been GRAS for many years, but that GRAS standing is being questioned more and more as the immunogenicity of microbial transglutaminase is being discovered. Interesting Reading:  Microbial Transglutaminase Is a Very Frequently Used Food Additive and Is a Potential Inducer of Autoimmune/Neurodegenerative Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC8537092/
    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      There is a 10 year old post in this forum on Edy's and Dreyer's ice cream. The information is somewhat outdated and the thread is closed to further comment, so here is a new one. Edy's And Dreyer's Grand Vanilla Bean Ice Cream - 1.5 Quart is labeled "Gluten Free". This is a different answer than years gone by. I don't know the answer for any other flavor at this moment. On 1 May, 2026, Edy's website says: "As a general rule, the gluten in Edy's and Dreyer's® frozen dessert products is present only in the added bakery products, such as cookies, cake or brownies. We always label the eight major food allergens on our package by their common name. We recommend to always check the label for the most current information before purchasing and/or consuming a product. The exception to this rule is our Slow Churned French Silk frozen dairy dessert, which contains gluten in the natural flavors." https://www.icecream.com/us/en/brands/edys-and-dreyers/faq It seems that Edy's and Dreyer's are more celiac-friendly than they were 10 years ago. Once I found enough information to make today's buying decision, I stopped researching.
    • Aretaeus Cappadocia
      EDG 3 years ago fine, now it shows focal villous blunting,

      By Aretaeus Cappadocia · Posted

      probably not your situation @Mimiof2, but allow me to add one more to @trents list of celiac-mimics: "olmesartan-induced sprue-like enteropathy"  
    • knitty kitty
      Terrible Neurological Symptoms

      By knitty kitty · Posted

      My dad had an Abdominal Aortic Aneurysm.  Fortunately, it was discovered during an exam.  The doctor could feel my dad's heart beating in his stomach/abdomen.  The aneurysm burst when the doctor first touched it in surgery.  Since he was already hooked up to the bypass machine, my dad survived ten more years.  Close call! Triple A's can press on the nerves in the spinal cord causing leg pain.  I'm wondering if bowing the head might have increased the pressure on an aneurysm and then the nerves.   https://gulfcoastsurgeons.com/understanding-abdominal-aortic-aneurysm-symptoms-and-causes/ Abdominal Aortic Aneurysm Presenting as a Claudication https://pmc.ncbi.nlm.nih.gov/articles/PMC4040638/
×
×
  • Create New...