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March, 20 2015 Study, Celiac Linked To Candida Albicans.

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This deserves a comment. If you have been diagnosed with Celiac disease or gluten intolerance by a Celiac antibody blood panel and a negative biopsy, what you probably have is an overgrowth of the germinated form of candida albicans in the intestines. The symptoms you feel are caused by it and by the cross reaction with Gliadin antibodies. If you eliminate the yeast overgrowth, the cross reaction disappears and you reaction to Gluten does it as well.


This is probably the most relevant study about Celiac and gluten in the last 10 years. Surprise me nobody has commented. 



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That is not what I understood. The conclusion of the study states:

"These results support the hypothesis that CI may trigger CeD onset in genetically-susceptible individuals."

So, a Candida (fungal) infection may trigger celiac disease. It does not mention that if a Candida infection is resolved, then the gluten intolerance will resolve as well.

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See this :


"However, the dramatic decrease in anti-gliadin antibodies titers observed in the study of Brinkert et al.[40] after successful treatment of CI also supports the theory of cross-reactivity between anti-gliadin and anti-Hwp1 antibodies [20"


The protein Hwp1 presents in the germinated form of candida cause the developing of anti-Gliadin antibodies. Then , if you have a candida albicans overgrowth in the gut, you will have anti-Gliadin antibodies that will attack Gliadin every time you eat gluten. All candida sufferers reacts to Gluten. They can not tolerate Gluten and this study supports the cause.


If you were diagnosed only by a blood panel, you can not be sure it is Gliadin but can be candida as well. Both cause the anti-Gliadin antibodies to rise.


I am convinced there are many people diagnosed with Gluten intolerance or may be Celiac,in some cases, that what they have is an intestinal yeast overgrowth. I am aware of people who doesn't get better with a totally gluten free diet. 

The immune system can not distinguish between Gliadin and the protein Hwp1 present in the germinated form of candida because they have an almost identical protein sequence.


It is possible the overgrowth of candida triggers the developing of Celiac disease in genetically susceptible people. But, what about those who react to gluten and aren't genetically susceptibles ?? Those diagnosed with a positive blood panel and a negative biopsy ?? Those who doesn't get better following the most selective gluten free diet ??

Those who doesn't see the anti-Gliadin antibodies drop down after months or years of eating gluten free ??


I think this study leaves clear candida albicans wake up a response to Gliadin since the crossreactivity between Hwp1 and Gliadin.  

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I understood it like Cyclinglady did: CI can possibly bring on celiac disease but it doesn't say that curing the CI will cure celiac disease. A number of phyiscal traumas or illnesses can do this like pregnancy or mono, and this is true for all autoimmune diseases.  It may bring down your anti-gliadin test results (AGA IgA and AGA IgG) but it doesn't say it would normalize it.


The AGA tests are not used that often any more because of their low sensitivity and specificity. It is even thought by some doctors that the AGA may indicate non-celiac gluten sensitivity (NCGS) as well as celiac disease. The tests normally used now are tissue transglutaminase (tTG) and the deaminated gliadin peptides (DGP). The DGP tests are the best for testing for gluten-free diet compliance.  The tTG tests can stay elevated for a couple of years after going gluten-free, and in <5% it can be slightly elevated due to diabetes, hypothyroidism, crohn's, colitis, liver disease, or a serious infection - CI could be that infection (I've seen it in viruses and Lyme disease too).


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