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Confused about diagnosis

misa-21

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misa-21 Newbie
misa-21
Posted

So I have recently had a blood test for Celiac Disease  and these are the results that came back: 
TISSUE TRANSGLUTAM AB IGA: 1 U/mL
GLIADIN DEAMIDATED AB,IGA: 45 Units
GLIADIN DEAMIDATED AB,IGG: 3 Units

TISSUE TRANSGLUTAM AB IGA:   
<4           No Antibody Detected
 > or = 4       Antibody Detected

GLIADIN DEAMIDATED AB,IGA: 
<20    Antibody not detected                                                
  >or=20     Antibody detected

GLIADIN DEAMIDATED AB, IGG
<20    Antibody not detected
   > or=20    Antibody detected

 

and I also had a biospy done on my intestine, which came back negative for Celiac. My doctor seems confused whether or not I have Celiac or not and wants me to do another biopsy after going on the gluten challenge for a longer period of time. I was just wondering what exactly my blood work meant and if you think there's any chance that I do not have Celiac? I should also mention that during the first gluten challenge (after being off gluten for 3 weeks) I did not have any stomachaches, just some bloating occasionally. But I recently went back to eating gluten because I was thinking of doing another endoscopy and I do feel a little off and maybe some brain fog but nothing major, I really would prefer to not do another endoscopy but I'm so confused.

Thanks ! 

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cyclinglady Grand Master
cyclinglady
Posted
21 minutes ago, misa_21 said:

So I have recently had a blood test for Celiac Disease  and these are the results that came back: 
TISSUE TRANSGLUTAM AB IGA: 1 U/mL
GLIADIN DEAMIDATED AB,IGA: 45 Units
GLIADIN DEAMIDATED AB,IGG: 3 Units

TISSUE TRANSGLUTAM AB IGA:   
<4           No Antibody Detected
 > or = 4       Antibody Detected

GLIADIN DEAMIDATED AB,IGA: 
<20    Antibody not detected                                                
  >or=20     Antibody detected

GLIADIN DEAMIDATED AB, IGG
<20    Antibody not detected
   > or=20    Antibody detected

 

and I also had a biospy done on my intestine, which came back negative for Celiac. My doctor seems confused whether or not I have Celiac or not and wants me to do another biopsy after going on the gluten challenge for a longer period of time. I was just wondering what exactly my blood work meant and if you think there's any chance that I do not have Celiac? I should also mention that during the first gluten challenge (after being off gluten for 3 weeks) I did not have any stomachaches, just some bloating occasionally. But I recently went back to eating gluten because I was thinking of doing another endoscopy and I do feel a little off and maybe some brain fog but nothing major, I really would prefer to not do another endoscopy but I'm so confused.

Thanks ! 

Welcome!  

Your blood tests results were like mine with only the DGP IgA being elevated, yet my biopsies revealed moderate to severe patches of intestinal damage.  Patches.  Celiac disease can be patchy.  It is easy to miss damage areas where you realize the small intestine is the size of a tennis court.  I think you need to get copies of your records.  See if your GI took the recommended amount of biopsies and at the appropriate locations.  Perhaps he just two 1 or 2 when the recommendation is often 4 or more.  Then you could just be starting to develop celiac disease too.  You mentioned a challenge.  How long had you been gluten free and how long was the challenge before you had the endoscopy?   Do you have any physical markers like anemia or another autoimmune issue?  What made you go in for testing?  Finally, you can not go by symptoms as they tend to overlap with so many other illnesses.    I had anemia when I was diagnosed.  No GI issues at all.  

misa-21 Newbie
misa-21
Posted
  • Author

Thank you for the insight! I was only off gluten for about 2-3 weeks and then I did the gluten challenge for 3 weeks. I do not have anything else wrong besides that I getstomach aches often and am very susceptible to stomach bugs. I originally went for testing to the doctor 2 years ago,  I was very sick for about a week (couldn't eat, constantly in the bathroom, very lethargic, aches), and they performed multiple blood tests. I actually came up positive for celiac indicators but they never told me until this year when I was at the doctor again (I know... crazy) so I went gluten free for the 2-3 weeks and I went to the GI after this. 

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