Results!

[Smiles7127]

Hello everyone!!

I am a 23yo female college student who’s been experiencing a plethora of symptoms, and am trying to narrow down the cause. Being a new wife and working towards a degree in higher ed I am so tired of feeling unwell all of the time  especially and having constant stomach upset. I do have a family history of Celiacs so my neurologist ran a celiacs panel which I had never had done previously. I have an appointment to go over results but I do have questions about how to interpret these labs and if anyone has similar results to me that do in fact have celiacs! The Gliadin Ab lga did result back very high when compared to the reference range and would love to know your opinions and experiences.

 

here are my lab results:

 

Gliadin Ab IgA (Range: 0.0 - 14.9 U/mL): my result was 25 

IgA: (no range provided): my result was Sufficient

TISSUE TRANSGLUTAM: (range 0.0 - 14.9 U/mL): My result <0.5

 

I appreciate you all and look forward to your input! 

[Scott Adams]

Welcome to the forum.

Were you eating ~2 slices of wheat bread a day for at least 6 weeks before your blood test? If not, it's possible that your tissue transglutaminase test was a false negative, and your DGP-IgA result would have been higher.

It looks like your DGP-IgA (Deamidated Gliadin Peptide) test was positive, and you are not IgA deficient, so the test should be accurate. This article might be helpful. It breaks down each type of test, and what a positive results means in terms of the probability that you might have celiac disease. You next step may be an endoscopy, so you should keep eating gluten daily until all tests are completed.

Quote

The DGP-IgA test is considered to have high sensitivity and specificity. In general, the DGP-IgA test has been reported to have a sensitivity ranging from 75% to 95% and a specificity ranging from 90% to 100%. The DGP tests have been found to have a sensitivity of around 85-95% and a specificity of around 95-98%.

 

 

[trents]

Welcome to the forum, @Smiles7127!

The primary celiac antibody test used for diagnosing celiac disease is the tTG-IGA (Tissue Transgltaminase IGA). Yours' is negative. The Gliadin AB Iga is a secondary test used and not as reliable an indicator of celiac disease as is the tTG-IGA. By that I mean it is less definitive for celiac disease than is the tTG-IGA and could instead be due to something else. And I would not say your gliadin AB IGA is "very high" based on the reference range. That would seem to be an overstatement.

By some chance had you already started cutting back on gluten consumption by the time you were tested? If so, that would have skewed your test results downward.

Your next logical step would be to seek an endoscopy/biopsy of the small bowel lining to check or the damage done by celiac disease inflammation.

You may also have NCGS (Non Celiac Gluten Sensitivity) which shares many of the same symptoms with celiac disease, is 10x more common and for which there is no testing available yet.