Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

- Alba Therapeutics Corp: New Data For At-1001


ENF

Recommended Posts

ENF Enthusiast

ORLANDO, Fla., Oct. 7 /PRNewswire/ -- Alba Therapeutics Corporation presented results from two clinical studies this week at the American College of Gastroenterology (ACG) 2008 Annual Scientific Meeting. Data from study CLIN 1001-004, the first Phase IIa trial conducted in celiac disease and the first to assess the prevention of immunologic changes in celiac disease, showed that larazotide acetate (AT-1001) successfully demonstrated prevention of gluten-induced immunologic changes in celiac patients.

Complete article:

Open Original Shared Link


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



happygirl Collaborator

Thanks for posting this, ENF.

larry mac Enthusiast

As much as I would like to believe in a treatment for Celiac Disease, I can't put much trust in Alba. I attended a presentation calling for volunteers to participate in this study. I responded via email by filling out the supplied questionaire and followed up by telephone to the contacts provided at this presentation. I did not receive any replies. Not by email or phone.

Now, I would gladly accept a rejection for not meeting some study criteria. After all, in a double blind study, I would have a 50% chance of getting poisoned by intentionally ingesting gluten. In the study, you purpousely take gluten capsules daily before meals. But half the victims do so without the potential benefit of also receiving the actual drug that is supposed to negate said gluten exposure. These participents get a placebo.

But not bothering to even provide a courtesy reply indicates these people don't give a damn about us. They are only interested in profits. They haven't even finished this Celiac study yet, and already they are pushing this drug for IBS. I'm not sure they can be trusted.

best regards, lm

p.s., ENF, When I was a kid, I went to the movie theater on Saturday mornings. One of my favorite serials was Rocket Man. Even I, as a child, could probably fly with a suit with a big dial that had an UP and Down control on it! :D

ENF Enthusiast

I understand where you're coming from, Larry, but the suits and the scientists at Alba could be on different wavelengths. At least it's a start, and that's something. If they get it on the market, other research will hopefully follow.

I do not understand if AT-1001 is supposed to be a complete protection against immune responses to any amounts of gluten, or just enough to cover the equivalent of one slice of bread a day. From the way the article is written, it's for the former.

Have a good one.

elonwy Enthusiast

As far as the placebo issue is concerned, in order to have good solid results, unfortunately that is necessary. Everyone going into a study like this is well aware that they may not be getting the real meds. It sucks for those people, but control groups are necessary in this kind of science.

Generic Apprentice

I did particiapte in one of the Alba studies. Virginia Mason Hospital had the study in WA state. It wasn't directly Alba that you were dealing with, but rather whichever hospital, clinic or whatever Alba hired for your area. They had a huge amount of people respond. I recieved an initial generic thanks e-mail with a phone number to call, to further screen me.

The drug is intended for cross contamination issues at this point. They are hopeful it will help people with Crohn's also. At least that was the purpose a year ago.

Archived

This topic is now archived and is closed to further replies.

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Recent Activity

    1. - trents replied to Leslie Clark's topic in Gluten-Free Foods, Products, Shopping & Medications
      20

      Hidden Gluten in distilled vinegar

    2. - Mynx replied to Leslie Clark's topic in Gluten-Free Foods, Products, Shopping & Medications
      20

      Hidden Gluten in distilled vinegar

    3. - Mynx replied to Leslie Clark's topic in Gluten-Free Foods, Products, Shopping & Medications
      20

      Hidden Gluten in distilled vinegar

    4. - trents replied to Leslie Clark's topic in Gluten-Free Foods, Products, Shopping & Medications
      20

      Hidden Gluten in distilled vinegar

    5. - Mynx replied to Leslie Clark's topic in Gluten-Free Foods, Products, Shopping & Medications
      20

      Hidden Gluten in distilled vinegar


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      127,874
    • Most Online (within 30 mins)
      7,748

    Charli.stoz09
    Newest Member
    Charli.stoz09
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121k
    • Total Posts
      70.5k

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • trents
      Take it easy! I was just prompting you for some clarification.  In the distillation process, the liquid is boiled and the vapor descends up a tube and condenses into another container as it cools. What people are saying is that the gluten molecules are too large and heavy to travel up with the vapor and so get left behind in the original liquid solution. Therefore, the condensate should be free of gluten, no matter if there was gluten in the original solution. The explanation contained in the second sentence I quoted from your post would not seem to square with the physics of the distillation process. Unless, that is, I misunderstood what you were trying to explain.
    • Mynx
      No they do not contradict each other. Just like frying oil can be cross contaminated even though the oil doesn't contain the luten protein. The same is the same for a distilled vinegar or spirit which originally came from a gluten source. Just because you don't understand, doesn't mean you can tell me that my sentences contradict each other. Do you have a PhD in biochemistry or friends that do and access to a lab?  If not, saying you don't understand is one thing anything else can be dangerous to others. 
    • Mynx
      The reason that it triggers your dermatitis herpetiformis but not your celiac disease is because you aren't completely intolerant to gluten. The celiac and dermatitis herpetiformis genes are both on the same chronometer. Dermatitis herpetoformus reacts to gluten even if there's a small amount of cross contamination while celiac gene may be able to tolerate a some gluten or cross contamination. It just depends on the sensitivity of the gene. 
    • trents
      @Mynx, you say, "The reason this is believed is because the gluten protein molecule is too big to pass through the distillation process. Unfortunately, the liquid ie vinegar is cross contaminated because the gluten protein had been in the liquid prior to distillation process." I guess I misunderstand what you are trying to say but the statements in those two sentences seem to contradict one another.
    • Mynx
      It isn't a conjecture. I have gotten glitened from having some distilled white vinegar as a test. When I talked to some of my scientists friends, they confirmed that for a mall percentage of people, distilled white vinegar is a problem. The cross contamination isn't from wheat glue in a cask. While yhe gluten protein is too large to pass through the distillation process, after the distillation process, the vinegar is still cross contaminated. Please don't dismiss or disregard the small group of people who are 100^ gluten intolerant by saying things are conjecture. Just because you haven't done thr research or aren't as sensitive to gluten doesn't mean that everyone is like you. 
×
×
  • Create New...