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seraphim

Enterolab Gene Test Results

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I did the enterolab cheek swab and this is what came up:

 

Gluten Sensitivity Gene Test
HLA-DQB1 Molecular analysis, Allele 1      0604   

HLA-DQB1 Molecular analysis, Allele 2      0402   

Serologic equivalent: HLA-DQ   1,4  (Subtype 6,4)



 

TEST INTERPRETATION(S):

Interpretation of HLA-DQ Testing:  Although you do not possess one of the HLA-DQB1 genes predisposing to celiac disease (HLA-DQ2 or HLA-DQ8), HLA gene analysis reveals that you have one copy of a gene that predisposes to gluten sensitivity, in your case HLA-DQB1*0604. Having one of these genes means that each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. This test was developed and its performance characteristics determined by the American Red Cross - Northeast Division. It has not been cleared or approved by the U.S. Food and Drug Administration.

 

 

 

So does this mean i definitely don't have celiac and it's just gluten sensitive? I dunno if you need to have a gene to have celiac itself do you? Doesn't matter but it's got me wondering..if I don't have celiac does that mean no leaky gut etc? Anyone here well versed in this stuff?

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I did the enterolab cheek swab and this is what came up:

 

Gluten Sensitivity Gene Test

HLA-DQB1 Molecular analysis, Allele 1      0604   

HLA-DQB1 Molecular analysis, Allele 2      0402   

Serologic equivalent: HLA-DQ   1,4  (Subtype 6,4)

 

TEST INTERPRETATION(S):

Interpretation of HLA-DQ Testing:  Although you do not possess one of the HLA-DQB1 genes predisposing to celiac disease (HLA-DQ2 or HLA-DQ8), HLA gene analysis reveals that you have one copy of a gene that predisposes to gluten sensitivity, in your case HLA-DQB1*0604. Having one of these genes means that each of your offspring has a 50% chance of receiving this gene from you, and at least one of your parents passed it to you. This test was developed and its performance characteristics determined by the American Red Cross - Northeast Division. It has not been cleared or approved by the U.S. Food and Drug Administration.

 

 

 

So does this mean i definitely don't have celiac and it's just gluten sensitive? I dunno if you need to have a gene to have celiac itself do you? Doesn't matter but it's got me wondering..if I don't have celiac does that mean no leaky gut etc? Anyone here well versed in this stuff?

there is new research suggesting that there may be other genes that can be seen with celiac.

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Oh  my.....so much to be learned right? Do you know anything about what these genes in particular would mean? I'm just wondering if leaky gut was actually an issue with me or not.

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My doctor for one reason or another considers it to be celiac disease. I only had enterolab done before and had elevated results. I was having a lot of refluxy problems around that time and i've developed other problems that started within a couple months of going gluten free. On top of this it seems gluten affects my thyroid. I honestly dunno what it is but...that's all my doctor did...read the results from enterolab and considered it as such. I honestly can deal with gluten but i've had plenty of other problems that have popped up since that have made my life a living hell. Currently waiting on 23andme genetic testing for MTHFR for detox issues as i seem to have salicylate issues and that's a detox issue as well. I've heard a lot of people saying healing the gut is so important for that problem too but I guess I'm curious if I have leaky gut or not. Can you have leaky gut with gluten sensitivity? Either way. I've got the links you have me opened but I have to run again for now. Will take a look when I get home later. Thanks!

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There are no genetic tests or blood tests of any kind for "gluten sensitivity". despite what some labs will tell you.

 

The leading celiac specialists will tell you that.

 

The main celiac genes associated with celiac are HLA-DQ2 and HLA-DQ8--as of now. (those are the ones they are sure of)

 

The research suggest a DQ9 may be associated.

 

I hate to burst your bubble, but everyone who gets a test from enterolab has a "gluten sensitivity gene" according to the reports I have seem

on here, yet there is no scientific or medical data that proves there even is such a thing. 

 

I know you really wish to have evidence that you have celiac, but the truth is, genetic testing isn't proof anyway.

 

The genes associated with celiac merely suggest a link, not a "proof-positive" and some people with the gene never develop it at all

and genetic tests are only used as an exclusionary diagnosis.

 

"Up to one third of the U.S. population has the genes for celiac disease, but it
is thought that only 1-4% of them will actually develop the disease at some point
in their lifetimes. This means that people with DQ2 or DQ8 can develop celiac
disease, but the vast majority of them will not."
 
Univ. of Chicago Celiac Center

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Yeah I know I just thought if I had a gene for it it might seem like it more so. I don't really want celiac...i know i have gluten sensitivity but...i guess i'm trying to figure out the underlying cause of the other issues which many say is caused by leaky gut....so I'm on the prowl for causes.

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Seraphim, I did 23andme testing and got my results last month. I found that I had to do a LOT of digging to get the info I wanted. For celiac HLA genes, 23andme only reports DQ2.5 status, but using info on individual SNPs you can find out a lot more. I highly recommend SNPedia.com for all kinds of stuff, and geneticgenie.org for MTHFR info. Good luck - it's a steep learning curve!

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Thanks so much! I'm in a rather rotten spot since christmas and trying to map out my health issues to try and heal as best I can. It's not all gluten....I'm to the point of actually HOPING i have the MTHFR gene defect as it will give me some hope that I just have some detox issues that can be at least SOMEWHAT helped through proper care. Who wishes for that kind of thing to be wrong? heh. Apparently me. At least it's an answer you know?

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I completely understand hoping for "bad" results. I'm currently waiting on 23andme results for my teenage daughter and am sort of hoping something will turn up. At least if you know what is wrong, you can take steps to address it.

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Exactly...right now it looks like i can't detox high salicylates. I seem to be ok with moderate and a couple high foods. Apparently this can be a detox issue typically. I am generally always tired and have had depression issues and weakness over the years and i know that can be tied into b12 problems so we shall see!

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