Jump to content

  • You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

Has Anyone Heard Of Being Iga And Igg Deficient?

Aurora87

Recommended Posts

Aurora87 Newbie
Aurora87
Posted

As I wrote about before, I am in the process of trying to figure out if I have celiac disease.  However, my bloodwork all comes out negative because I have IgA and IgG subclass 2 and 3 deficiencies.  

 

Has anyone else heard of having both IgA and IgG deficiencies?  I guess the biopsy would be the only way to know for sure if I have celiac, right?  I have read about having an IgA deficiency, but not both.  My doctor wants me to see an immunologist about it.  Thanks!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


1desperateladysaved Proficient
1desperateladysaved
Posted

I wish I had the answer to this as I have asked on a few occasion, but haven't figured it out.  I suspect that I had been deficient in both.

 

Dee

SMRI Collaborator
SMRI
Posted

It's very "common".  My daughter is IgA deficient and IgG subclass 2, 3 and 4 deficient.  It's usually classified as CVID Open Original Shared Link .

 

Each of the IgG subclasses point to different symptoms, 2 and 4 relate to upper respiratory issues--lots of sinus infections, strep, pneumonia, etc.  Subclass 3 is digestive issues--which is why it's important to get these tests if you suspect some gluten issues---it might not be gluten and it might just be low IgG3.  If your overall IgG is low, you have some pretty major health issues and usually land in the hospital every time you get sick.  If you are old enough to remember the movie "Boy in the Plastic Bubble", that is what he had in the movie.

 

If you are going to need a biopsy only diagnosis because of low IgA and IgG, ask that they take a LOT of samples-10 or so.

Aurora87 Newbie
Aurora87
Posted
  • Author

Wow, thanks for your replies.  It's comforting to know this information.  I do remember hearing something about the "Bubble Boy" but I'm glad I'm not that deficient!  I have an appointment at the Celiac Disease Center at Columbia University in mid-October and I will bring all my test results with me.  I do think I probably need a biopsy and I will be sure that they are going to take a lot of samples.  If everything is clear, my next stop will be the immunologist.

 

Just out of curiousity, SMRI, does your daughter have celiac disease or gluten sensitivity?  I would think that eliminating gluten and thus eliminating a source of inflammation might help if you have immune deficiencies, but I'm not an expert.  I will probably try a gluten free diet even if I don't have celiac to see if it helps me. 

 

Have a great weekend!

SMRI Collaborator
SMRI
Posted

Wow, thanks for your replies.  It's comforting to know this information.  I do remember hearing something about the "Bubble Boy" but I'm glad I'm not that deficient!  I have an appointment at the Celiac Disease Center at Columbia University in mid-October and I will bring all my test results with me.  I do think I probably need a biopsy and I will be sure that they are going to take a lot of samples.  If everything is clear, my next stop will be the immunologist.

 

Just out of curiousity, SMRI, does your daughter have celiac disease or gluten sensitivity?  I would think that eliminating gluten and thus eliminating a source of inflammation might help if you have immune deficiencies, but I'm not an expert.  I will probably try a gluten free diet even if I don't have celiac to see if it helps me. 

 

Have a great weekend!

 

She is not Celiac.  The two really aren't the same thing, although they have similar symptoms.  Her issues are more with getting sick all the time but she does have some digestive issues that again, are similar to Celiac but not because of gluten.

LauraTX Rising Star
LauraTX
Posted

Sorry to arrive to this thread late.  SMRI gave you some great info.  I have Celiac disease and also have Common Variable Immunodeficiency with IgG and IgA deficiencies and reduced vaccine response.  CVID and low immunoglobulin levels can cause false negatives in some Celiac blood tests, and false mild positives in biopsy samples for Celiac diagnosis.  You are very lucky to have a good doctor who checked the total immunoglobulin levels.  Get on in to the immunologist... as you have indicated an understanding of already, there are varying degrees of immune deficiency issues, so the immunologist will be able to determine what is going on, and then you can bring that information to the Celiac clinic so they know what they need to do to properly diagnose you.  Autoimmune disorders are prevalent in people with CVID.  Let us know what they say, I am always very interested in any other Celiac/CVID patient other than myself.

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      134,077
    • Most Online (within 30 mins)
      10,442
    terrificterry
    Newest Member
    terrificterry
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.7k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      Sigh. I posted this yesterday based on the Safeway website. I went back again today to their website to double check. On the page where they are selling Vanilla Bean flavor, it has a distinct Certified Gluten Free label. Other flavors on the Safeway website didn't have the gluten-free statement. Today I went into the store. None of the flavors I looked at, including Vanilla Bean, have a Gluten Free statement. Is it safe? Who knows. The ingredients are either safe or nearly safe (some have "natural flavor"). There are warnings about "contains milk and soy" but not about wheat - this implies they are safe, but again, who knows. On the other hand, every flavor I checked of their Slow Churn line of ice creams has wheat as an ingredient. 100% not safe.
    • knitty kitty
      Edy's and Dreyer's ice cream

      By knitty kitty · Posted

      Do keep in mind that many of the newly diagnosed have lactose intolerance.  This is because the villi lining the intestinal tract are damaged, and can no longer make the enzyme lactAse which breaks down the milk sugar lactOse.  When the villi grow back (six months to two years), they can again produce the enzyme lactAse, and lactose intolerance is resolved.  However, some people (both those with and without Celiac Disease) are genetically programmed to stop producing lactase as they age.   Do be aware that many processed foods, including ice cream, use Microbial Transglutaminase, a food additive commonly called "meat glue," used to enhance texture and flavor.  This microbial transglutaminase has the same immunogenicity as tissue transglutaminase which the body produces in response to gluten in people with Celiac Disease.  Tissue Transglutaminase (tTg IgA) is measured to diagnose Celiac Disease in blood tests.  Microbial Transglutaminase acts the same as Tissue Transglutaminase, causing increased intestinal permeability and inflammation.   New findings show that microbial transglutaminase may be able to trigger Celiac Disease and other autoimmune and neurodegenerative diseases.   Microbial Transglutaminase is not required to be listed on ingredients labels as it's considered a processing aid, not an ingredient in the U.S.  Microbial Transglutaminase has been GRAS for many years, but that GRAS standing is being questioned more and more as the immunogenicity of microbial transglutaminase is being discovered. Interesting Reading:  Microbial Transglutaminase Is a Very Frequently Used Food Additive and Is a Potential Inducer of Autoimmune/Neurodegenerative Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC8537092/
    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      There is a 10 year old post in this forum on Edy's and Dreyer's ice cream. The information is somewhat outdated and the thread is closed to further comment, so here is a new one. Edy's And Dreyer's Grand Vanilla Bean Ice Cream - 1.5 Quart is labeled "Gluten Free". This is a different answer than years gone by. I don't know the answer for any other flavor at this moment. On 1 May, 2026, Edy's website says: "As a general rule, the gluten in Edy's and Dreyer's® frozen dessert products is present only in the added bakery products, such as cookies, cake or brownies. We always label the eight major food allergens on our package by their common name. We recommend to always check the label for the most current information before purchasing and/or consuming a product. The exception to this rule is our Slow Churned French Silk frozen dairy dessert, which contains gluten in the natural flavors." https://www.icecream.com/us/en/brands/edys-and-dreyers/faq It seems that Edy's and Dreyer's are more celiac-friendly than they were 10 years ago. Once I found enough information to make today's buying decision, I stopped researching.
    • Aretaeus Cappadocia
      EDG 3 years ago fine, now it shows focal villous blunting,

      By Aretaeus Cappadocia · Posted

      probably not your situation @Mimiof2, but allow me to add one more to @trents list of celiac-mimics: "olmesartan-induced sprue-like enteropathy"  
    • knitty kitty
      Terrible Neurological Symptoms

      By knitty kitty · Posted

      My dad had an Abdominal Aortic Aneurysm.  Fortunately, it was discovered during an exam.  The doctor could feel my dad's heart beating in his stomach/abdomen.  The aneurysm burst when the doctor first touched it in surgery.  Since he was already hooked up to the bypass machine, my dad survived ten more years.  Close call! Triple A's can press on the nerves in the spinal cord causing leg pain.  I'm wondering if bowing the head might have increased the pressure on an aneurysm and then the nerves.   https://gulfcoastsurgeons.com/understanding-abdominal-aortic-aneurysm-symptoms-and-causes/ Abdominal Aortic Aneurysm Presenting as a Claudication https://pmc.ncbi.nlm.nih.gov/articles/PMC4040638/
×
×
  • Create New...