Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Celiac.com!
    eNewsletter
    Donate

Test Results 3 Year Old

Mneri

Recommended Posts

Mneri Newbie
Mneri
Posted

Hello I would like some help with my son's results

TTG IgA 21 weak positive

TTG IgG negatige

EMA negative

AGA IgAnegative

AGA IgG negative

ARA Negative

IgA normal

Are these results inconclusive?

Link to comment
Share on other sites
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


cyclinglady Grand Master
cyclinglady
Posted

Well, it appears that you got one positive out of the panel! The AGA tests are older and considered less reliable. The newer DPG tests are better. I personally only had one positive on my panel too. My biopsy via endoscopy showed moderate to severe damage.

It might be worth repeating the panel and including the newer DPG tests. Be sure to keep your son on gluten until all testing is complete! Otherwise, the tests could be invalid/negative. Endoscopy/biopsy is usually the final step in diagnosis. At least six biopsies should be taken.

Kids that small are not as easy to diagnose. I am sorry that the diagnosis process is not easier.

Here is a link to a reputable source and talks all about Celiac disease:

Open Original Shared Link

I hope your son feels better soon.

Link to comment
Share on other sites
StephanieL Enthusiast
StephanieL
Posted

Sorry OP, I have to ask this on the "not easy to dx",  I hear this all the time here.  Is it really that difficult or is it that they may not have as many positives as older people simply because there hasn't been enough time to cause enough damage?  

Link to comment
Share on other sites
cyclinglady Grand Master
cyclinglady
Posted

Based on my limited research and the fact that I am not a doctor or a scientist, I think celiac disease in general can be difficult to diagnose. Nothing is clear cut. I assume that it can be more difficult for a small child as they can not always verbalized symptoms and their parents are often given poor advice from their doctors and many other reasons I am not aware of or have forgotten!

Even the experts (e.g. A. Fasano MD) do not always agree about the diagnostic process and even point out that the process is not set in stone and is evolving. The old five pillars of Diagnosis (and reasons the pillars are not rock solid)

1. Signs and Symptoms compatible with celiac disease (some have no symptoms)

2. Positive Serological blood tests (10 to 20 % fail this)

3. Genetic markers HLA-DQ2 or DQ8 (2 to 3 % of those with celiac disease do not have these genes)

4. intestinal damgage found via endoscopy (damage can be patchy and missed)

5. symptom resolution after going gluten free (there are several possible reasons a person might not respond)

Source: (Fasano, Alessio, MD, "Gluten Freedom", Turner Publishing Company, New York, New York 2014)

The answer to your question about damage not be more advanced? Who knows? Not even the experts can agree. Fansano states "Preliminary studies of children who are at genetic risk of celiac disease have shown that even the best serological marker of the condition that is currently available, the IGA anti-TTG antibody, may flucuate over time from a border line positive to a normal value and vice versa."

Nothing is concrete! Celiac disease is difficult! (Dang, typing on an iPad is difficult! )

My advice is to parents is to research (like you do, Stephanie) and be the best advocate (as you are) for your child (or yourself). I am thankful that this forum allows for discussion and as members we help each other. Someday, medical science will really understand celiac disease (I hope!)

Link to comment
Share on other sites
StephanieL Enthusiast
StephanieL
Posted

I just wasn't sure if there was an actual scientific reasoning to this as I see it mentioned often but haven't seen anything stating "it's harder in kids".

Also, just an a side not, Fassano's 5 pillars DO NOT apply to kids so that's kind of a moot point ;)  

Clear as mud!  Right? lol

Link to comment
Share on other sites
nvsmom Community Regular
nvsmom
Posted

Hello I would like some help with my son's results

TTG IgA 21 weak positive

TTG IgG negatige

EMA negative

AGA IgAnegative

AGA IgG negative

ARA Negative

IgA normal

Are these results inconclusive?

 

 

Hard to say.  A positive tTG IgA is usually (95% of the time) caused by celiac disease.  The rare time a positive is not caused by celiac disease, it is usually a weak positive, and is caused by thyroidiitis, crohn's, colitis, diabetes, liver disease or a serious infection.  If any of those could apply, then that positive may not be caused by celiac disease.

 

Don't go gluten-free until all testing is done (ike DGP IgA, DGP IgG, endoscopic biopsy).  Once testing is done, and if it is still inconclusive, have him go gluten-free for  6 months to see if it helps.  After being gluten-free, retest after 6 months and see if your results go down.  That would point to celiac disease.

 

You could also do the genetic tests.  97% of celiacs have the DQ2 and or the DQ8.

 

 

And from what I have read, they suspect childhood celiac disease is harder to diagnose because it is early celiac disease.  They may not be serologically sick enough yet.  :(

Link to comment
Share on other sites
Mneri Newbie
Mneri
  • Author
Posted

Thank you all we have an appointment with the gastro in a couple of weeks. We really don't want to do an endoscopybut we'll see what she recomends.

Link to comment
Share on other sites
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      121,093
    • Most Online (within 30 mins)
      7,748
    Eva Ann
    Newest Member
    Eva Ann
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.3k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • trents
      Waiting for urgent referral.

      By trents · Posted

      Oh, okay. The lower case "b" in boots in your first post didn't lead me in the direction of a proper name. I thought maybe it was a specialty apothecary for people with pedal diseases or something.
    • Scott Adams
      50 YO Male Recently Diagnosed with Celiac Disease

      By Scott Adams · Posted

      In the Europe the new protocol for making a celiac disease diagnosis in children is if their tTg-IgA (tissue transglutaminase IgA) levels are 10 times or above the positive level for celiac disease. According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy: Blood Test Alone Can Diagnose Celiac Disease in Most Children and Adults TGA-IgA at or Above Five Times Normal Limit in Kids Indicates Celiac Disease in Nearly All Cases No More Biopsies to Diagnose Celiac Disease in Children! There are other things that may cause elevated tTg-IgA levels, but in general a reaction to gluten is the culprit:    
    • cristiana
      Waiting for urgent referral.

      By cristiana · Posted

      Hi @trents Just seen this - Boot's is a chain of pharmacies in the UK, originally founded in the 19th Century by a chap with the surname, Boot.  It's a household name here in the UK and if you say you are going to Boot's everyone knows you are off to the pharmacist! Cristiana
    • Denise I
      Celiac Dietician

      By Denise I · Posted

      I am looking to find a Celiac Dietician who is affiliated with the Celiac Disease Foundation who I can set up an appointment with.  Can you possibly give some guidance on this?  Thank you!
    • Posterboy
      14 year old with Celiac & EOE still suffering...

      By Posterboy · Posted

      Nacina, Knitty Kitty has given you good advice. But I would say/add find a Fat Soluble B-1 like Benfotiamine for best results.  The kind found in most Multivitamins have a very low absorption rate. This article shows how taking a Fat Soluble B-1 can effectively help absorption by 6x to7x times. https://www.naturalmedicinejournal.com/journal/thiamine-deficiency-and-diabetic-polyneuropathy quoting from the article.... "The group ingesting benfotiamine had maximum plasma thiamine levels that were 6.7 times higher than the group ingesting thiamine mononitrate.32" Also, frequency is much more important than amount when it comes to B-Vitamin. These are best taken with meals because they provide the fat for better absorption. You will know your B-Vitamin is working properly when your urine becomes bright yellow all the time. This may take two or three months to achieve this.......maybe even longer depending on how low he/you are. The Yellow color is from excess Riboflavin bypassing the Kidneys....... Don't stop them until when 2x a day with meals they start producing a bright yellow urine with in 2 or 3 hours after the ingesting the B-Complex...... You will be able to see the color of your urine change as the hours go by and bounce back up after you take them in the evening. When this happens quickly......you are now bypassing all the Riboflavin that is in the supplement. The body won't absorb more than it needs! This can be taken as a "proxy" for your other B-Vitamin levels (if taken a B-Complex) ...... at least at a quick and dirty level......this will only be so for the B-1 Thiamine levels if you are taking the Fat Soluble forms with the Magnesium as Knitty Kitty mentioned. Magnesium is a Co-Factor is a Co-factor for both Thiamine and Vitamin D and your sons levels won't improve unless he also takes Magnesium with his Thiamine and B-Complex. You will notice his energy levels really pick up.  His sleeping will improve and his muscle cramps will get better from the Magnesium! Here is nice blog post that can help you Thiamine and it's many benefits. I hope this is helpful but it is not medical advice God speed on your son's continued journey I used to be him. There is hope! 2 Tim 2:7 “Consider what I say; and the Lord give thee understanding in all things” this included. Posterboy by the grace of God,  
×
×
  • Create New...