Jump to content

  • You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.


  • Celiac.com Sponsor (A1):
    Celiac.com Sponsor (A1-M):

Dgp/iga Results Positive

patz

Recommended Posts

patz Newbie
patz
Posted

Hi all, I just recvd panel back. All neg except the new GDP IGA came back 38. GDP IGG was neg. Doc wants me to see GI. With only one positive test but supposedly quite accurate can I assume celiac disease? I have bloating, gas, nausea and sometimes just don't feel well.

Mainly need to know if worth getting scoped on only one positive test. Help!!

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Wolicki Enthusiast
Wolicki
Posted

This is actually the first I have heard of this test. After reading this study:

Open Original Shared Link

I think that a biopsy is wise. It appears to be a very reliable indicator. Good luck!

  • 1 year later...
gfcolorado Newbie
gfcolorado
Posted

Hi all, I just recvd panel back. All neg except the new GDP IGA came back 38. GDP IGG was neg. Doc wants me to see GI. With only one positive test but supposedly quite accurate can I assume celiac disease? I have bloating, gas, nausea and sometimes just don't feel well.

Mainly need to know if worth getting scoped on only one positive test. Help!!

I just came across your post and realize it's been awhile so I'm not sure if you'll get this. I just had a positive only GDP biopsy and was wondering what your biopsy came back. Thanks!

Emsstacey Rookie
Emsstacey
Posted

gfcolorado, are you saying that only your deamidated gliadin was positive and your biopsy was positive, too?

I ask because my only antibody that came back positive was the deamidated gliadin at a 31. I did not get the scope because I had one done about 10 years ago looking for the same thing. I never did get the results, though, just told it was ok. I'm actually going to go pick them up this week to see for myself what they say.

Just curious! Thanks!

melissa222 Newbie
melissa222
Posted

I just got my results back I had deamidated gliadin antibodies at 36, along with a DQ8 gene (I got the genetic test at the same time). Other tests were negative. I have major celiac symptoms. I'm having the scope done next week. My GI Dr, who was recommended to me by a local celiac support group, said this test was a very strong indication that I do have celiac. From what I've read this test is very specific to celiac, and a valuable new test in detecting celiac in patients, like me, who have tested negative with the other tests.

Emsstacey Rookie
Emsstacey
Posted

Wow. It sounds like a lot more people with only the positive DGP. I guess that I need to go retest and find a GI. I would be very grateful if you update after your scope!

Skylark Collaborator
Skylark
Posted

DGP is considerably more sensitive than the other tests in the celiac panel.

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


melissa222 Newbie
melissa222
Posted

My biopsy came back normal. Dr says it is not celiac but to try gluten free diet. I'm bummed because I thought I had hope to feel better.

ravenwoodglass Mentor
ravenwoodglass
Posted

My biopsy came back normal. Dr says it is not celiac but to try gluten free diet. I'm bummed because I thought I had hope to feel better.

Don't be bummed get on the diet. If your DGP was positive you do need to avoid all gluten. False negative biopsies are very common. Get on the diet strictly and you should be feeling better soon.

Skylark Collaborator
Skylark
Posted

My biopsy came back normal. Dr says it is not celiac but to try gluten free diet. I'm bummed because I thought I had hope to feel better.

You do have hope to feel better. My mom came back negative on antibodies and biopsy. She feels a heck of a lot better off gluten. With the DGP there is certainly something going on and you might be pleasantly surprised.

pain*in*my*gut Apprentice
pain*in*my*gut
Posted

My biopsy came back normal. Dr says it is not celiac but to try gluten free diet. I'm bummed because I thought I had hope to feel better.

My biopsy was normal, too. My GI doc dismissed me without any follow up to discuss my obvious Celiac symptoms. According to him (and a lot of docs), if the biopsy was negative, I don't have a problem. What an idiot. :angry:

When my rheumatologist took one look at my DGP levels, he said it was most certainly Celiac and to avoid gluten like the plague. :o DGP is very specific for Celiac, so in his opinion, it trumps the biopsy because of the false negative probability if the damage is patchy in the intestines.

I am now one month gluten free, and my stomach issues are 80% better than before! I think you will be pleasanly suprised by how good you will feel off of gluten! B)

gfcolorado Newbie
gfcolorado
Posted

gfcolorado, are you saying that only your deamidated gliadin was positive and your biopsy was positive, too?

I ask because my only antibody that came back positive was the deamidated gliadin at a 31. I did not get the scope because I had one done about 10 years ago looking for the same thing. I never did get the results, though, just told it was ok. I'm actually going to go pick them up this week to see for myself what they say.

Just curious! Thanks!

When I was originally tested 3 years ago, all my tests (TTG, EMA, DGP) were positive and so was my biopsy. This time, only my DGP was positive. My TTG and EMA were negative. I think I'm going to get another endoscopy just to see what's going on. If I do, I'll let you know.

gfcolorado Newbie
gfcolorado
Posted

My biopsy was normal, too. My GI doc dismissed me without any follow up to discuss my obvious Celiac symptoms. According to him (and a lot of docs), if the biopsy was negative, I don't have a problem. What an idiot. :angry:

When my rheumatologist took one look at my DGP levels, he said it was most certainly Celiac and to avoid gluten like the plague. :o DGP is very specific for Celiac, so in his opinion, it trumps the biopsy because of the false negative probability if the damage is patchy in the intestines.

I am now one month gluten free, and my stomach issues are 80% better than before! I think you will be pleasanly suprised by how good you will feel off of gluten! B)

I think there is so much they still don't know about Celiac and Gluten Sensitivity and the DGP test. When I went to a Celiac conference about 3 years ago, they hardly talked about Gluten sensitivity. When I went last year, the top Celiac researchers all talked about it. Most doctors say that you don't have Celiac until your biopsy is positive and no one really knows at what point you become positive. I had really bad stomach aches my whole life but wasn't diagnosed with Celiac until I was 43. My biopsy was positive and my stomach aches are gone but would I have tested positive when I was a kid or 10 years prior? I don't know but going off of gluten would have made my stomach aches go away and might have prevented villous atrophy and other auto immune diseases.

Thanks everyone for sharing your info!

  • 2 weeks later...
melissa222 Newbie
melissa222
Posted

Yall were right! After about 11 days gluten free my energy levels picked up and I have felt incredible...more energy, anxiety is gone, more focus...I have not felt this good in years. Now I'm going to patiently wait for my physical problems to improve! It's almost miraculous. To think had I not figured this out on my own, I would've lived out the rest of my life completely miserable. Doctors are grossly mis/uneducated about this!! All the time n money spent on Dr visits and tests, when the whole time it was food. :/ I consider myself lucky. So many suffer so much longer and never know how poisonous gluten can be. It should come with a warning label!

Skylark Collaborator
Skylark
Posted

That's wonderful news! I'm so glad to hear you're feeling better. Thanks a lot for coming back to update us and share your good news!

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):

  • Member Statistics

    • Total Members
      134,086
    • Most Online (within 30 mins)
      10,442
    Joseph01
    Newest Member
    Joseph01
    Joined
  • Celiac.com Sponsor (A20):
  • Celiac.com Sponsor (A22):

  • Forum Statistics

    • Total Topics
      121.7k
    • Total Posts
      1m
  • Celiac.com Sponsor (A21):

  • Upcoming Events

  • Posts

    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      Sigh. I posted this yesterday based on the Safeway website. I went back again today to their website to double check. On the page where they are selling Vanilla Bean flavor, it has a distinct Certified Gluten Free label. Other flavors on the Safeway website didn't have the gluten-free statement. Today I went into the store. None of the flavors I looked at, including Vanilla Bean, have a Gluten Free statement. Is it safe? Who knows. The ingredients are either safe or nearly safe (some have "natural flavor"). There are warnings about "contains milk and soy" but not about wheat - this implies they are safe, but again, who knows. On the other hand, every flavor I checked of their Slow Churn line of ice creams has wheat as an ingredient. 100% not safe.
    • knitty kitty
      Edy's and Dreyer's ice cream

      By knitty kitty · Posted

      Do keep in mind that many of the newly diagnosed have lactose intolerance.  This is because the villi lining the intestinal tract are damaged, and can no longer make the enzyme lactAse which breaks down the milk sugar lactOse.  When the villi grow back (six months to two years), they can again produce the enzyme lactAse, and lactose intolerance is resolved.  However, some people (both those with and without Celiac Disease) are genetically programmed to stop producing lactase as they age.   Do be aware that many processed foods, including ice cream, use Microbial Transglutaminase, a food additive commonly called "meat glue," used to enhance texture and flavor.  This microbial transglutaminase has the same immunogenicity as tissue transglutaminase which the body produces in response to gluten in people with Celiac Disease.  Tissue Transglutaminase (tTg IgA) is measured to diagnose Celiac Disease in blood tests.  Microbial Transglutaminase acts the same as Tissue Transglutaminase, causing increased intestinal permeability and inflammation.   New findings show that microbial transglutaminase may be able to trigger Celiac Disease and other autoimmune and neurodegenerative diseases.   Microbial Transglutaminase is not required to be listed on ingredients labels as it's considered a processing aid, not an ingredient in the U.S.  Microbial Transglutaminase has been GRAS for many years, but that GRAS standing is being questioned more and more as the immunogenicity of microbial transglutaminase is being discovered. Interesting Reading:  Microbial Transglutaminase Is a Very Frequently Used Food Additive and Is a Potential Inducer of Autoimmune/Neurodegenerative Diseases https://pmc.ncbi.nlm.nih.gov/articles/PMC8537092/
    • Aretaeus Cappadocia
      Edy's and Dreyer's ice cream

      By Aretaeus Cappadocia · Posted

      There is a 10 year old post in this forum on Edy's and Dreyer's ice cream. The information is somewhat outdated and the thread is closed to further comment, so here is a new one. Edy's And Dreyer's Grand Vanilla Bean Ice Cream - 1.5 Quart is labeled "Gluten Free". This is a different answer than years gone by. I don't know the answer for any other flavor at this moment. On 1 May, 2026, Edy's website says: "As a general rule, the gluten in Edy's and Dreyer's® frozen dessert products is present only in the added bakery products, such as cookies, cake or brownies. We always label the eight major food allergens on our package by their common name. We recommend to always check the label for the most current information before purchasing and/or consuming a product. The exception to this rule is our Slow Churned French Silk frozen dairy dessert, which contains gluten in the natural flavors." https://www.icecream.com/us/en/brands/edys-and-dreyers/faq It seems that Edy's and Dreyer's are more celiac-friendly than they were 10 years ago. Once I found enough information to make today's buying decision, I stopped researching.
    • Aretaeus Cappadocia
      EDG 3 years ago fine, now it shows focal villous blunting,

      By Aretaeus Cappadocia · Posted

      probably not your situation @Mimiof2, but allow me to add one more to @trents list of celiac-mimics: "olmesartan-induced sprue-like enteropathy"  
    • knitty kitty
      Terrible Neurological Symptoms

      By knitty kitty · Posted

      My dad had an Abdominal Aortic Aneurysm.  Fortunately, it was discovered during an exam.  The doctor could feel my dad's heart beating in his stomach/abdomen.  The aneurysm burst when the doctor first touched it in surgery.  Since he was already hooked up to the bypass machine, my dad survived ten more years.  Close call! Triple A's can press on the nerves in the spinal cord causing leg pain.  I'm wondering if bowing the head might have increased the pressure on an aneurysm and then the nerves.   https://gulfcoastsurgeons.com/understanding-abdominal-aortic-aneurysm-symptoms-and-causes/ Abdominal Aortic Aneurysm Presenting as a Claudication https://pmc.ncbi.nlm.nih.gov/articles/PMC4040638/
×
×
  • Create New...