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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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Whey Protein Gluten Problem

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Whey protein is gluten free, but I have notice several manufacturers now include peptide bonded glutamine as an extra ingredient in their supplements which is apparently derived from hydrolysed wheat gluten.

Most manufacturers with the added peptide bonded glutamine do now not claim the whey protein as gluten free but I have noticed at least one who does.

I have emailed the manufacturers and await responses.

But does anybody out there know if this peptide bonded glutamine does contain gluten or has it been treated such that the gluten content is removed ?

This stuff is appearing in lots of protein supplements that would previously have been gluten free.

Any thoughts??

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Glutamine is one of the amino acids (building blocks of proteins- see http://en.wikipedia.org/wiki/Glutamine) and isn't actually related to gluten, even though they sound similar.

"peptide bonded" is also a bit of a confusing phrase. A "peptide bond" is the way 2 amino acids stick together. So peptide bonded glutamine just means "we added extra glutamine, and it's attached the way it usually is".

I never knew my college chemistry classes would be so useful.

-Em

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Glutamine is one of the amino acids (building blocks of proteins- see http://en.wikipedia.org/wiki/Glutamine) and isn't actually related to gluten, even though they sound similar.

"peptide bonded" is also a bit of a confusing phrase. A "peptide bond" is the way 2 amino acids stick together. So peptide bonded glutamine just means "we added extra glutamine, and it's attached the way it usually is".

I never knew my college chemistry classes would be so useful.

-Em

I dont have a problem with glutamine, just the peptide bonded glutamine.

Here are some quotes from a few articles:-

"Glutamine Peptide derives from wheat gluten and therefore appears brownish in color and may have an unpleasant taste"

"glutamine peptide (wheat gluten hydrolysate) in "

"Peptide Bonded Glutamine 800 mg. (as hydrolized wheat gluten)"

"Peptide Bonded Glutamine (as hydrolized wheat gluten)"

"Glutamine Peptide by definition is L-Glutamine, peptide bonded (a chemical bond between two amino acids) to another amino acid or several other amino acids in a chain (protein). Within the supplement industry Glutamine Peptide means . . . . wheat protein. What

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I should've know college chemistry wouldn't actually apply to the real world. You're absolutely right. I looked at some of the links you sent, and it looks like it does nearly always derive from wheat, at least in human food products- it's a wheat gluten hydrolysate. Supposedly it can be made gluten-free: http://www.freepatentsonline.com/6692933.html

There is corn gluten hydrolysate, but the references to that are almost all about how it can be used as an herbicide.

I'd suggest calling the companies that claim that their supplements are gluten-free. Ask them where their peptide-bonded glutamine comes from, and if it's wheat, I'd ask for lab test results to confirm the gluten-free claim before eating any of it.

Or just finding a different supplement :(

-Em

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I have been using a whey based protein powder that is labelled gluten-free. I was worrying about the dairy content but now I have symptoms of a Glutening ( fatigue, constipation, headache). I will go and check the label !

(edited) YES - it has Glutamine Peptide. What does this mean? Have I been Glutening myself ?

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Whey protein is gluten free, but I have notice several manufacturers now include peptide bonded glutamine as an extra ingredient in their supplements which is apparently derived from hydrolysed wheat gluten.

Most manufacturers with the added peptide bonded glutamine do now not claim the whey protein as gluten free but I have noticed at least one who does.

I have emailed the manufacturers and await responses.

But does anybody out there know if this peptide bonded glutamine does contain gluten or has it been treated such that the gluten content is removed ?

This stuff is appearing in lots of protein supplements that would previously have been gluten free.

Any thoughts??

Stear clear of proteins that contain glutamine peptides as in most cases they are derived from wheat. Your top quality proteins such as isolates still have peptides in them and are therefore not gluten free. Be cautious with weight gainers also. I'm researching protein powders to be sure they are safe enough for people with Celiac Disease. ;)

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Stear clear of proteins that contain glutamine peptides as in most cases they are derived from wheat. Your top quality proteins such as isolates still have peptides in them and are therefore not gluten free. Be cautious with weight gainers also. I'm researching protein powders to be sure they are safe enough for people with Celiac Disease. ;)

Yes I think that any supplements with glutamine peptide, or peptide bonded glutamine, should be avoided. I also agree with the caution with weight gainers as most of these seem to contain gluten.

I have had limited success in getting replies from manufacturers. The manufactuer with the protein supposedly containing glutamine peptide and claiming it to be gluen free has replied to state that their distributor had made an error in their advertising and that there was no glutamine peptide in the powder and it was gluten free.

You say you are researching protein powders. What sort of research?? Do you mean your own investigations or do you mean scientific research??

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Hi,

I just noticed your L-glutamine controversy. This worries me since it has seemed like L-glutamine has helped me considerably.

However the kind I use is pure--not with an energy bar or anything else. Its pharmaceutical grade and says its gluten, wheat, soy, milk, sugar etc. free. Its called Essential Glutmine Powder by Iron Tek. Taking the pure powder its pretty inexpensive and supposedly more effective.

I take it at night just before I go to bed and often first thing in the morning on an empty stomach with co-enzyme B vitamins and bromelain/papain and nattokinase (these last for the fibronilytic/anti-scar tissue effect--important for the gut as well as scar tissue elsewhere as well as thickening arteries etc.). It seems to give me more energy and I at least thought it helps heal the gut. I've also read L-glutamine naturally helps kick in more anti-aging hormones. I have noticed no ill effect.

Any comments??

--Yolo

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Hi,

I just noticed your L-glutamine controversy. This worries me since it has seemed like L-glutamine has helped me considerably.

However the kind I use is pure--not with an energy bar or anything else. Its pharmaceutical grade and says its gluten, wheat, soy, milk, sugar etc. free. Its called Essential Glutmine Powder by Iron Tek. Taking the pure powder its pretty inexpensive and supposedly more effective.

I take it at night just before I go to bed and often first thing in the morning on an empty stomach with co-enzyme B vitamins and bromelain/papain and nattokinase (these last for the fibronilytic/anti-scar tissue effect--important for the gut as well as scar tissue elsewhere as well as thickening arteries etc.). It seems to give me more energy and I at least thought it helps heal the gut. I've also read L-glutamine naturally helps kick in more anti-aging hormones. I have noticed no ill effect.

Any comments??

--Yolo

To further muddy up the discussion, I found this reference that says L-glutamine and peptide bonded glutamine are not the same thing.

http://www.criticalbench.com/Glutamine-Pep...ment-Review.htm

I agree that we should steer clear of anything containing peptide bonded glutamine, but pure form L-glutamine should be fine. I think the article listed above has a link for the L-glutamine powder that says on its label it is gluten free.

Sigh, this all used to be sooo much easier B)

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L-Glutamine is glutamine which is gluten free.

It is the glutamine peptide, or peptide bonded glutamine, which should be avoided.

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L-Glutamine is glutamine which is gluten free.

It is the glutamine peptide, or peptide bonded glutamine, which should be avoided.

Thank heavens!

Has anyone else noticed how the L-Glutamine helps the gut and boosts the hormonal and muscular systems--as well as lessens sugar cravings?

--Yolo

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Thank heavens!

Has anyone else noticed how the L-Glutamine helps the gut and boosts the hormonal and muscular systems--as well as lessens sugar cravings?

--Yolo

Just so you know L-Glutamine helps the body repair, our bodies simply do not produce enough of it, and even less as we age.....this is why it's been helping. By you taking it at night is the best thing you can do for yourself, as the body naturally repairs itself while we sleep. Cudo's to you!

Now as for sugar craving??? Couldn't tell ya, you might be getting less craving due to your diet and eating patterns? As for boosting the muscular system and hormonal system - how long has it been since you got a cold or flu, while taking L-Glutamine???? Probably been a while as it also boost your immune system!

Keep up the good work - stay healthy!

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If you're looking for a safe gluten-free whey protein to drink try EAS. They are one of the very few products on the market that are completely gluten-free. I have personally checked this out for a client who has celiac disease.

Another safe protein - a gainer style protein shake that is completely gluten free is Ultimate Nutrition's Muscle Juice. All flavours are safe for celiac patients and people whom prefer a gluten-free healthy lifestyle.

All the best,

Elaine and Peter

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I'm so happy I found this thread!! I switched back to being a vegetarian last summer and have been taking supplements. I thought I was feeling crappy because my stomach wasn't used to them or something. No...glutamine peptide is the culprit. Thanks for the tips on the muscle milk and EAS...I'm switching over.

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If you're looking for a safe gluten-free whey protein to drink try EAS. They are one of the very few products on the market that are completely gluten-free. I have personally checked this out for a client who has celiac disease.

Another safe protein - a gainer style protein shake that is completely gluten free is Ultimate Nutrition's Muscle Juice. All flavours are safe for celiac patients and people whom prefer a gluten-free healthy lifestyle.

All the best,

Elaine and Peter

You can also add bioplex to that list.

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Thanks for this, at least now I know what to look for and why I was feeling symptoms the last couple of days (insert head banging smiley here) :(

btw, with the EAS powders I was told they are not great if you are lactose intolerant but otherwise they rank up there

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I use Gold Standard 100% Whey.... I called the company and they said it was gluten free. It doesn't make me sick. I read the ingredients again after reading this thread... they say... Protein Blend(Whey Protein Isolate, Whey Protein Concentrate, Whey Peptidies) Is that the same thing as the glutamine peptides?

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I use Gold Standard 100% Whey.... I called the company and they said it was gluten free. It doesn't make me sick. I read the ingredients again after reading this thread... they say... Protein Blend(Whey Protein Isolate, Whey Protein Concentrate, Whey Peptidies) Is that the same thing as the glutamine peptides?

I see your hypoglycemic. Doesn't whey protein give you hypoglycemia? The sugar (Lactose) in whey?

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I supplement 5 grams of L-Glutamine in the morning and I also use protein powders with added L-Glutamine.

L-Glutamine helps to heal the lining of the intestines and also aids in muscle recovery. It is the amino acid that is most abundant and most used by skeletal muscle.

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I was thinking about getting the whey protein isolate microfiltrated from trueprotein.com. In the allergen warnings, it states that it is entirely gluten-free, so it should be fine.

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I contacted Optimum Nutrition and asked for a list of their gluten free products. This is the reply I received on Saturday (4 days ago):

Thank you for your interest in Optimum Nutrition products. The

following products are those to avoid; those which absolutely contain

gluten:

100% Whey Gold Standard-Cookies n' Cream (cookie pieces)

100% Casein Gold Standard (cookie pieces)

Serious Mass-all flavors(glutamine peptides)

Aftermax-all flavors (glutamine peptides)

Pro Complex-all flavors (glutamine peptides)

Pro Complex Gainer-all flavors (glutamine peptides)

Nitro-Core 24 - all flavors (glutamine peptides)

Lift Bar - Cookies & Cream (glutamine peptides)

Mor'sos-Cookies and Cream (cookie pieces) - Discontinued

*To the best of our knowledge these are the only products that contain

gluten. While we are not adding gluten to our other products, we cannot

say with 100% certainty that our other products are gluten-free. We use

the same equipment to make products with and without gluten. Although

the equipment is cleaned in-between, trace amounts of gluten may remain.

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Glutathione (GSH) happens to be your body

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Jay Robb makes various protein powders...whey, egg white, rice, and he states on his site they are gluten free. I've tried them, they are good, but quite expensive. Whole Foods sells them, too. Here's a link: http://www.jayrobb.com/jayRobbProtein.asp

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Hi,

My gym uses this company called Royal Smoothie Company: Whey protein and also advertises energy boosts, Focus boosts and fat burning boosts. I can't reach the company to see if these products are gluten free. Is anyone familiar with these products. I would love some of these drinks but am afraid to try them.

Thanks,

Rachel

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    • I am sorry that I was not clear.    I only mentioned  your diagnostic background, not to discredit you, but because without any lab results (other than a positive gene test), how can you be sure that gluten (shampoo containing wheat protein) was the actual culprit (not a guess) of your symptoms?  It is common for celiacs to receive follow-up antibodies to monitor their dietary compliance.  This is not perfect, but it is the only tool in the toolbox for now.   My husband has been gluten free 12 years prior to my diagnosis.  He went gluten free per the poor advice of his GP and my allergist.  So, I am not trying to discount your diagnosis at all.  I am just trying to see if other lab tests (e.g. liver tests that were elevated previously for you when you were still consuming gluten) were measured after your shampoo exposure.   I am curious because I have had issues over the last year.  I was glutened last January, had the flu, a tooth infection, a cold and a tooth extraction, three rounds of antibiotics (verified to be gluten free) within a month or so.  Like, you, I am very careful.  I have no idea as to how I was exposed.   The last time I ate out was a year ago and even then it was at at 100% gluten free restaurant.   My hubby did not have any symptoms at this time.  He is like my canary.    I went to my GI and my DGP IgA was off the charts even some three months later.   My celiac-related symptoms diminished in three months, but I struggled with autoimmune hives for six.  My GI offered to do an endoscopy in the summer.  Instead I chose to follow the Fasano diet.  I still was not feeling well.  In December, my antibodies were 80.  They were either on a decline or they were increasing again.  I opted for the endoscopy.  My biopsies revealed a healed small intestine (you could see the villi on the scope too).  But I was diagnosed with chronic gastritis and had a polyp removed.   So, all this time I thought my celiac disease was active, but it was NOT the source of my current gut issues.   Again, my apologies.  I just wanted to know how you know for SURE that hydrologized wheat protein from someone else’s shampoo and conditioner could reach your small intestine to trigger an autoimmune reaction.  Maybe, like me, Gluten was not the actual culprit.    
    • The reason I think it was the shampoo? Process of elimination. Our house is almost entirely gluten free (except for this shampoo which slipped through the cracks until I read the ingredient label). My husband has bread that he eats at lunch, but he practices something that resembles aseptic technique from the lab when he's making his sandwiches. He's been doing this for years now and I've never been glutened from within my home. The previous week I hadn't eaten out, I cooked all my food, I don't eat processed food and I never eat something from a shared facility.  Usually if I get glutened it's a single dose sort of thing and it follows a very predictable course, to the point where I can estimate when I got glutened within 24 hours of when it happened. However, this time, I was feeling achy and arthritic and moody for about a week before it got bad enough for me to recognize it as the result of gluten exposure, at which point we went searching and found the shampoo (and conditioner, which does leave more of a residue than shampoo), which he immediately stopped using. Within three days I was feeling back to normal (which is the usual course for me).  Sure, it could have been something else, but I know how sensitive I am, and, as silly as it sounds, it was the only thing that made sense. The other thing you said: You're correct, mine was not a rock solid celiac diagnosis, but I have no doubt that gluten is the problem. I was SICK. I went through two different gluten challenges in an effort to get a more straightforward diagnosis during which I was a barely functioning human being. Consuming gluten may not have given me blunted villi or elevated antibodies, but it did inflame my gut, and actually started to damage my liver. If you look at my diagnosis thread, I had elevated liver enzymes, which have been correlated with celiac disease in the past. There was no alternative explanation for the liver enzymes, he checked EVERYTHING.  I too am a scientist and I have spent a lot of time with the literature trying to make sense of my condition.  https://www.ncbi.nlm.nih.gov/pubmed/26150087 I also have no doubt that gluten was damaging my intestines in some way, as any prolonged gluten exposure in the past has inevitably been followed by a severe FODMAP intolerance that goes away once I've eliminated the gluten and given myself a month or so to heal.  I also had a very fast diagnosis following the onset of symptoms (~1 year) so it's possible that the disease never had a chance to manifest as full celiac. I wasn't willing to eat gluten long enough to find out. As a result of my diagnosis, hazy as it was, I am *meticulously* gluten free. It is not a fad for me. I don't occasionally cheat. It is my life, for better or worse. All of that being said, I'm not sure what my diagnosis has to do with your question. You say you're not trying to be rude, but when you bring up my diagnosis in a thread that has nothing to do with diagnostics, it seems like you're trying to undermine the validity of my disease or the validity of my input in this forum. If I'm being hypersensitive, I apologize, but that's how you came across on my end. I'll admit that the fact that my diagnosis wasn't more straight forward does make me a bit defensive, but I promise that even if I didn't have a solid diagnosis, I interact with the world as though I did, and I'm not out there giving people the wrong idea about celiac disease by not taking it seriously. If there was a connection between your question and my diagnostics that I missed I would appreciate you giving me the chance to better understand what you were asking. 
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