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- knitty kitty replied to glucel's topic in Super Sensitive People17iron digestibility
@glucel, There's a strong correlation between thiamine deficiency, hypoxia, and insomnia. Thiamine is needed to help red blood cells carry oxygen. In thiamine deficiency, hypoxia (lack of oxygen in tissues) occurs, and this can result in insomnia. Hypoxia causes systemic inflammation, increases inflammatory markers, and is associated with cardiovascular... -
- Aretaeus Cappadocia commented on Scott Adams's article in Latest Research3New Research Reveals How Antibody Genes May Shape the Immune Response in Celiac Disease
Thanks. Not a big thing, particularly because most likely it is "true" but not yet demonstrated.- antibodies
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- glucel replied to glucel's topic in Super Sensitive People17iron digestibility
Thanks to everybody for your help. I reread the dr's notes from the biopsy procedure and it seems I had worse than atrofied villi. It was termed flattened mucosa. So while iron ferratin levels are normal my bet is, as kitty alluded to, iron not getting into cells. I have dr appointment next mo but don't hold out a lot of hope, There is strong correlation... -
- Scott Adams commented on Scott Adams's article in Latest Research3New Research Reveals How Antibody Genes May Shape the Immune Response in Celiac Disease
Thanks for the thoughtful comment. You are right that the study’s main conclusion was cautious: the researchers found that inherited antibody-gene variants significantly shape the naïve B-cell receptor repertoire, including usage of some gene segments involved in celiac-related antibody responses, but they did not find strong evidence that polymorphisms in...- 1
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- knitty kitty replied to Bogger's topic in Related Issues & Disorders6
Osteoporosis: Does the body start rebuilding bones after starting a gluten-free diet?
I have osteoporosis and have crushed three vertebrae. I supplement with Lysine, Tryptophan, threonine, calcium, Boron, Vitamins D, A, and K, and the B vitamins (folate, B12, and Thiamine B1 especially for bone health). I tried Fosomax, but it tore up my insides. I prefer the supplements. I feel better and my bones feel stronger. References...
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By knitty kitty · Posted
@glucel, There's a strong correlation between thiamine deficiency, hypoxia, and insomnia. Thiamine is needed to help red blood cells carry oxygen. In thiamine deficiency, hypoxia (lack of oxygen in tissues) occurs, and this can result in insomnia. Hypoxia causes systemic inflammation, increases inflammatory markers, and is associated with cardiovascular events. Curiously, thiamine deficiency is correlated with excessive daytime sleepiness and oversleeping. I found a combination of Tryptophan, Pyridoxine B 6, magnesium, and L-theanine works very well for inducing sleep. Sometimes, I add Passion Flower Extract and/or Sweet Melissa. There's no side effects the next morning with Passion Flower, it just induces sleepiness. Sweet Melissa is groovy, and has anti-inflammatory effects on the digestive system. I prefer to take 250 mg Benfotiamine and 100 mg Thiamine TTFD in the mornings and another dose of Benfotiamine at lunch. I try not to take any thiamine after four p.m. because it keeps my brain so energized and wanting to think... Oh, I do take a combination of another form of thiamine (sulbutiamine), Pyridoxine and Cobalamine for a pain reliever sometimes, but I can sleep after taking that. But thiamine does help regulate circadian rhythm. Make sure you're getting Omega Three fats! They'll help you satisfy that late night carb craving with fewer carbs. Flaxseed oil, olive oil, sunflower seed oil. Nuts and nut butters, like walnuts and cashews, are good, too, if you can tolerate them. Try taking the 100mg thiamine HCl before your aerobics and see if there's a difference. Sweet dreams! References: Network Pharmacology Analysis of the Potential Pharmacological Mechanism of a Sleep Cocktail. ......(Skip to Section Four) https://pmc.ncbi.nlm.nih.gov/articles/PMC11201840/ Effects of Melissa officinalis Phytosome on Sleep Quality: Results of a Prospective, Double-Blind, Placebo-Controlled, and Cross-Over Study https://pubmed.ncbi.nlm.nih.gov/39683592/ -
Thanks to everybody for your help. I reread the dr's notes from the biopsy procedure and it seems I had worse than atrofied villi. It was termed flattened mucosa. So while iron ferratin levels are normal my bet is, as kitty alluded to, iron not getting into cells. I have dr appointment next mo but don't hold out a lot of hope, There is strong correlation of low red blood cells and insomnia so at least I finally solved that one after few yrs of being mislead. I intend to take stop taking 100 mg b1 at noon time and start 150 mg benfotiamin. I may or may not add the the 100 mg b1evening meal. BTW, last night had 1/3 lb beef. potato then 2 bowls cereal and an apple later in the eve. I generally do my areobics before supper so maybe that contributes to the hunger.
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By knitty kitty · Posted
I have osteoporosis and have crushed three vertebrae. I supplement with Lysine, Tryptophan, threonine, calcium, Boron, Vitamins D, A, and K, and the B vitamins (folate, B12, and Thiamine B1 especially for bone health). I tried Fosomax, but it tore up my insides. I prefer the supplements. I feel better and my bones feel stronger. References: A composite protein enriched with threonine, lysine, and tryptophan improves osteoporosis by modulating the composition and metabolism of the gut microbiota https://pubmed.ncbi.nlm.nih.gov/41915427/ -
By knitty kitty · Posted
@Aileen Cregan, I was put on high blood pressure medication, too. But I was able to correct my high blood pressure by supplementing with Thiamine Vitamin B 1. I am no longer on high blood pressure medication. I feel much better without the medication. I continue to supplement Thiamine in the form Benfotiamine. The particular high blood pressure medication I took was Norvasc (amlodipine), which causes thiamine deficiency by blocking thiamine transporters so that thiamine cannot enter cells. Benfotiamine can get into cells by merging with the cell membrane, thus bypassing nonfunctional thiamine transporters. Indapamide also blocks thiamine transporters! The use of this type of medications that block thiamine precipitated Wernickes Encephalopathy. My doctors did not recognize the connection to Thiamine deficiency. I nearly died. Talk to your doctor and dietician about supplementing with Benfotiamine, a fat soluble form of thiamine that bypasses thiamine transporters. Ask for an Erythrocyte Transketolace Activity Assay to check your thiamine levels asap. Routine blood tests for thiamine are not an accurate measure of thiamine in the body. Absorption of essential vitamins like Thiamine is altered in Celiac Disease due to damaged villi, inflammation and dysbiosis. The Gluten Free diet can be lacking in vitamins and minerals. Discuss supplementing with all the eight B vitamins, the four fat soluble vitamins and necessary minerals. Please keep us posted on your progress! References: Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3) https://pubmed.ncbi.nlm.nih.gov/31764942/ The Pivotal Role of Thiamine Supplementation in Counteracting Cardiometabolic Dysfunctions Associated with Thiamine Deficiency https://pmc.ncbi.nlm.nih.gov/articles/PMC11988323/ -
By knitty kitty · Posted
Hi, @Sue7171, I thought you might be interested in this article about Lyme disease and the discussion after the article. I found this article enlightening. The finding that not only can alpha gal be problematic, but advantageous infection with Staph aureus can be problematic. The Acari Hypothesis, VII: accounting for the comorbidity of allergy with other contemporary medical conditions, especially metabolic syndrome https://pmc.ncbi.nlm.nih.gov/articles/PMC11983536/
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