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Help With Test Results


Zebra007

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Zebra007 Contributor
Hi, I have had the following blood work done and I wonder if you could possibly  help me with the results, its in Spanish to complicate things further! I was never formally diagnosed with Gluten intolerance and I have been Gluten free now since around Sept 2014, the guy that I spoke with o the phone  today indicated that this showed that I do not have Gluten intolerance, although he did explain it could be wrong and that a biopsy is the definitive test really.  Problem is he was telling me this over the phone in Spanish and so I couldn't really grasp what he was saying ha ha! and now I see the word indeterminado
 
Inmunologia                                               Resultado            Unidades          Referencias
Analisis
 
Inmunoglobulina A                                       246                   Mg/dL                  70-400
Transglutaminasa 1gG                                  0.9                    U/mL
Negativo < 12 U/mL Indeterminado
12-18 U/mL Positivo > 18 U/mL
Transglutaminasa                                                                    U/mL
tisular 1gA                                                       1.6
Negativo < 0 - 15
Positivo > 15
 
Alergias   
Inmunologia                                                   39.5                  UI/mL                     ND - 87             
 
 
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cyclinglady Grand Master

Well, from the test results it looks like you do not have celiac disease, but the test could be invalid if you have been gluten free. (Your signature states that you have been gluten-free since sept. 2014.). When was the blood drawn? Also, this was an incomplete panel, but again, if you were gluten free you would most likely still get a negative result.

I open others can add their opinions.

Remember, I am not a doctor!

Zebra007 Contributor

Thank you cycling lady...that is exactly what I thought, and the blood test was done yesterday.  I have stuck firmly to a Gluten free diet.  Not sure what to think now.

 

 

I am waiting on some results for Mast Cell and my GI wanted to do these tests as well.

ravenwoodglass Mentor

You have to be eating gluten for the test to be accurate. If you want a diagnosis of Celiac then you need to get back on gluten for a couple of months and then retest. 

Zebra007 Contributor

I knew that for some tests you needed to be eating Gluten, but for this  particular test my GI indicated that we might pick up some sort of measurement...I cant go back to eating Gluten, but really I do wish I had done things in the right order because I really really wanted to know without doubt.

nvsmom Community Regular

I knew that for some tests you needed to be eating Gluten, but for this  particular test my GI indicated that we might pick up some sort of measurement...I cant go back to eating Gluten, but really I do wish I had done things in the right order because I really really wanted to know without doubt.

Your GI may be incorrect.  The tissue transglutaminase (tTG IGA) test can remain positive in some celiacs for many months after going gluten-free, especially if they have other health issues like thyroiditis, but in many others, their tTG IgA returns to normal within weeks of going gluten-free.  

 

Are you planning on staying very strictly gluten-free in the long run?  Sounds like it.  If so, you don't "need" a diagnosis to go gluten-free and treat suspected celiac disease or non-celiac gluten sensitivity (NCGS), for which there are no blood tests.

Zebra007 Contributor

I see, thanks.  I will continue going gluten-free as I know I am gluten intolerant, it just would have been nice to have had it confirmed. I didn't ask my GI for the blood test, he wanted it because I am struggling at the moment with many allergies/problems and I think he wanted to be able to get a clearer picture of what was going on.

 

I am so sad that I didn't listen to my body years ago.  I used to say to my husband "There is something wrong with bread!! every time I eat it I end up with a bloated stomach"  it sounds ridiculous now... I honestly didn't realize that there was something wrong with me, not the bread!


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BlessedMommy Rising Star

I have to stay gluten free, because eating gluten for testing could be fatal for me(due to the nature of my symptoms), so I've been gluten free for 5 years now. It'd be interesting to know if I had celiac disease, but I can't even imagine eating gluten for 2-3 months straight. I had a TIA while on gluten for only 10 days, so I'm guessing that a full blown stroke could be in the works, if I did a full length gluten trial.

Most people who know me well understand my situation and know that cheating isn't an option and it's gotten easier with time. As far as doctors, I cannot afford to go to them anyway. I may eventually do bloodwork to check my nutrient levels, though.

Zebra007 Contributor
BM..TIA, that sounds terrible, I had to look that one up!  I  think your right that you could possibly end up having a major stroke if you did a full length gluten trial...
 
For myself I went through a tricky period with GERD, and its hard to find the words to express the misery that can cause, its a wretched condition to have, and I had to make some big changes to kick that to the curb, and going gluten-free was one of them, and so I would never want to risk having that return, plus of course I have other illness issues.  

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    • Nicbent35
      Well I had a moment yesterday morning where I accidentally gave her gluten. She wanted what I was eating and I forgot and let her have a few bites of toast. It was a really bad night last night with her behavior. Will a few bites of bread influence their behavior that much or could it just be a coincidence?
    • Scott Adams
      The first set of results show two positive results for celiac disease, so at the very least it looks like you could have it, or at the least NCGS.   Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.      
    • Scott Adams
      Elevated tissue transglutaminase IgA (tTG-IgA) levels are highly specific for celiac disease, and they are a key biomarker used in its diagnosis. However, there are some rare instances where elevated tTG-IgA levels have been reported in conditions other than celiac disease. While these cases are not common, they have been documented in the literature. Below are some examples and references to studies or reviews that discuss these scenarios:  1. Non-Celiac Gluten Sensitivity (NCGS)    - NCGS typically does not cause elevated tTG-IgA levels, as it is not an autoimmune condition. However, some individuals with NCGS may have mild elevations in tTG-IgA due to intestinal inflammation or other factors, though this is not well-documented in large studies.    - Reference: Catassi, C., et al. (2013). *Non-Celiac Gluten Sensitivity: The New Frontier of Gluten-Related Disorders*. Nutrients, 5(10), 3839–3853. [DOI:10.3390/nu5103839](https://doi.org/10.3390/nu5103839)  2. Autoimmune Diseases    - Elevated tTG-IgA levels have been reported in other autoimmune conditions, such as type 1 diabetes, autoimmune hepatitis, and systemic lupus erythematosus (SLE). This is thought to be due to cross-reactivity or polyautoimmunity.    - Reference: Sblattero, D., et al. (2000). *The Role of Anti-Tissue Transglutaminase in the Diagnosis and Management of Celiac Disease*. Autoimmunity Reviews, 1(3), 129–135. [DOI:10.1016/S1568-9972(01)00022-3](https://doi.org/10.1016/S1568-9972(01)00022-3)  3. Chronic Liver Disease    - Conditions like chronic hepatitis or cirrhosis can sometimes lead to elevated tTG-IgA levels, possibly due to increased intestinal permeability or immune dysregulation.    - Reference: Vecchi, M., et al. (2003). *High Prevalence of Celiac Disease in Patients with Chronic Liver Disease: A Role for Gluten-Free Diet?* Gastroenterology, 125(5), 1522–1523. [DOI:10.1016/j.gastro.2003.08.031](https://doi.org/10.1016/j.gastro.2003.08.031)  4. Inflammatory Bowel Disease (IBD)    - Some patients with Crohn’s disease or ulcerative colitis may have elevated tTG-IgA levels due to intestinal inflammation and damage, though this is not common.    - Reference: Walker-Smith, J. A., et al. (1990). *Celiac Disease and Inflammatory Bowel Disease*. Journal of Pediatric Gastroenterology and Nutrition, 10(3), 389–391. [DOI:10.1097/00005176-199004000-00020](https://doi.org/10.1097/00005176-199004000-00020)  5. Infections and Parasites    - While infections (e.g., giardiasis) are more commonly associated with false-positive tTG-IgA results, chronic infections or parasitic infestations can sometimes lead to elevated levels due to mucosal damage.    - Reference: Rostami, K., et al. (1999). *The Role of Infections in Celiac Disease*. European Journal of Gastroenterology & Hepatology, 11(11), 1255–1258. [DOI:10.1097/00042737-199911000-00010](https://doi.org/10.1097/00042737-199911000-00010)  6. Cardiac Conditions    - Rarely, heart failure or severe cardiovascular disease has been associated with elevated tTG-IgA levels, possibly due to gut ischemia and increased intestinal permeability.    - Reference: Ludvigsson, J. F., et al. (2007). *Celiac Disease and Risk of Cardiovascular Disease: A Population-Based Cohort Study*. American Heart Journal, 153(6), 972–976. [DOI:10.1016/j.ahj.2007.03.019](https://doi.org/10.1016/j.ahj.2007.03.019)  Key Points: - Elevated tTG-IgA levels are highly specific for celiac disease, and in most cases, a positive result strongly suggests celiac disease. - Other conditions causing elevated tTG-IgA are rare and often accompanied by additional clinical findings. - If celiac disease is suspected, further testing (e.g., endoscopy with biopsy) is typically required for confirmation. If you’re looking for more specific studies, I recommend searching PubMed or other medical databases using terms like "elevated tTG-IgA non-celiac" or "tTG-IgA in non-celiac conditions." Let me know if you’d like help with that!
    • MaryMJ
      I called zero water and they state their filters do not contain gluten or gluten containing ingredients. 
    • trents
      I agree. Doesn't look like you have celiac disease. Your elevated DGP-IGG must be due to something else. And it was within normal at that after your gluten challenge so it is erratic and doesn't seem to be tied to gluten consumption.
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