parker

Enterolab retested the most recent member of the family that had the 0202 gene (that was tested a couple of months ago), to confirm the results. 0202 or 0201, avoiding gluten will happen in either case.

Yes, I know they did send it out to another lab. I think saying the tests lie is a little strong, though. It's just that the prior technology (Bonfils, I presume) wasn't able to "see" as much detail, so they could not differentiate between 0201 and 0202. In any case, it's good to know the tests are now more accurate. The transcription problem is a little...

In case anyone is interested, I did finally get clarified what happened with the genetic testing of the family I mentioned previously. Two of the gene tests were done by Enterolab in 2006, and they did not have access to a high resolution method at that time. 0201 genotypes then may have really been 0202, as they could not tell at the time. Now the tests...

Yes, I spoke with Enterolab and they indicated there must have been a mistyping. I've put the results of 3 generations below. One of the parents in Family B is a child of Family A. You'll see 3 cases of 0201, and no other cases of 0202. 0202 must be the error. Enterolab is going to have that test run again to confirm. --------------------- Family...

Although I will follow-up with Enterolab to see what they can tell me, I'm wondering if it really matters, for practical purposes. Is it the case that both 0201 and 0202 both are forms of DQ2, which predisposes to Celiac? If so, it won't change my understanding of the results. Thanks for any clarification! Patrick

I was a little confused as well about 0201, which prompted my question about a possible lab error? Hopefully some enlightened member here will shed some light on this... Patrick

OK, I think I may have finally answered my own question, thanks to the information contained in this link: HLA DQ Info If I understood that correctly, then the following possibilities exist for each child: DQ8/DQ5 DQ8/DQ6 DQ2/DQ5 DQ2/DQ6 Do I have this correct? Is it also correct that Parent 1 has 2 genes that predispose to Celiac, DQ8 and...

I am trying to help someone understand the Enterolab gene testing results. In particular, how the nomenclature works in terms of passing genes from parent to child. I understand each child gets one gene from each parent. I've included the results from this family below (2 parents, 3 children). Using these actual results, how should I interpret this? ...

I would appreciate thoughts on the thread below. I have to get this straight so I can make sure I'm a smart shopper for my son. Thanks! Patrick -------------------------------------------------- I just looked at the following document, and have a question about interpretation. ("American Celiac Disease Alliance Food Labeling (FALCPA) Fact Sheet,...

I'm interested in the significance of the pill in testing by people more informed than I am about Celiac disease (rather new in our family). Assuming testing proves the efficacy and safety, I wonder how long it would take to get this out in the marketplace? It's also exciting to me to soon (hopefully!) have a better (less expensive and faster) test available...

Do you happen to know what % of people who DO have Celiac do NOT have the main genes (DQ2 and DQ8)? Until we find out what my son's status is, it doesn't matter for our situation, but if you happen to know, that would be a useful data point for understanding the predisposition for the disease. Thanks!

I now believe my son's results reflect the wrong test that was ordered-- it was a more general HLA typing, or at least an outdated test. One of the more well-known labs had this to say about the results: "Thank you for your correspondence. I have consulted with Dr. ____ on these HLA results, and he has informed me that the tests that were run are somewhat...

After doing a little more research and reading this: "HLA molecules exist in two classes. HLA-A, HLA-B and HLA-C molecules make up the class I molecules and HLA-DR, HLA-DQ and HLA-DP molecules make up the class II molecules." Given that the test result only listed Type I HLA, I'm wondering if the test even checked for the class II molecules. i.e.,...

I think my faxed results may have been off on one factor, as it was not printed very clearly. I'm guessing Cw*03 should really be Cw09, based on the fact that Cw9 was printed very clearly. Corrected version is: Alleles Detected: Serological equivalents: HLA A*02 Antigen 1: A2 HLA A*03 Antigen 2: A3 HLA B*18 Antigen 1: B18 HLA B*44 Antigen 2: B...

After doing more research, I realized the test that was done for my son probably used a more recent nomenclature than what is described in the enterolab tests. Hopefully that will help in targeting appropriate resources for a proper interpretation. I'll copy a little explanation of the enterolab test below, followed by my son's test resutls. Please let...