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Whoops ...just noticed my spelling in my forum title...I mean two copies! :rolleyes:

Does anyone have any links about the increased risk of Celiac Disease with someone like my self having 2 copies of HLA_DQ2?

Does anyone else out there have 2 copies of HLA-DQ 2?

HLA-DQB1 Molecular Analysis, Allele 1: 0201

HLA-DQB1 Molecular Analysis, Allele 2: 0202

Serologic equivalent: HLA-DQ 2,2 (Subtype 2,2)

The report said something like...by having the 0202 gluten sensitivity gene along with the 0201 Celiac Gene...my risk is greater and the possibility is more severe disease...

I was looking for more information regarding this connection...

Thanks

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I don't have any links for you but I also am positive for HLA-DQ2 plus a subset of that gene and am scheduled for a second upper endoscopy on Tues. Dec. 1st. I would love to know exactly what that means too. My gastroenterologist said that the combination that I have puts me in the second highest risk group and I am not really sure what that means. My first endo. only showed inflammation but that gastroenterologist didn't take any biopsies from the duodenal bulb where he saw lots of inflammation so my current gastro. really feels he needs to see what is going on in there. If I find any links I will be more than happy to share them with you. I am sorry you also have the genetic markers that I do but I am glad that there is someone else out there searching for answers to the best health possible.

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I don't have the HLA DQ2 marker (I'm HLA DQ8), but here are some links that may be helpful.....

A thread from this board about a year ago:

http://www.celiac.com/gluten-free/index.php?showtopic=52131

Some Wikipedia articles with info on HLA genetics:

http://en.wikipedia.org/wiki/Coeliac_disease

http://en.wikipedia.org/wiki/HLA-DQ

http://en.wikipedia.org/wiki/HLA-DQ2

And here is a JPEG version of the Prometheus risk table:

http://bp3.blogger.com/_oSrs_NcPb_U/R6-EvV...20for%20web.jpg

Sounds as though you do have a higher risk of developing celiac disease than most.

I guarantee you that there are LOTS of members here that are double DQ2! I hope you hear soon from one of our resident genetic experts.... :)

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I've got two copies as well. My celiac gastroenterologist told me that that meant all of my children would carry the DQ2.

I think I actually had two of the same and a third that was subset of DQ2 -- have to look it up.

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I'm no genetic expert, and though I've tried to understand it, it's a completely foreign language to me. :lol:

I am double DQ2 (0201), which puts me in the highest risk group for developing celiac. It also means that both my parents have at least one gene and my children have at least one. I don't know my husband's genetics, but right now I'm becoming suspect about my son and whether he has celiac or not.

My mom was tested for celiac last year, and it came back negative. She doesn't feel bad, so she figures she doesn't have it. As far as I know, my dad doesn't have it, but we don't exactly talk everyday...

Anyway, I think for me, because I have double copies, if one didn't get 'triggered', there was always the other gene. I am sure that my pregnancy with my first was the trigger for me, although my mom says that in my childhood I always hated stuff like pasta, pancakes... so who knows. Either way, if my mom only carries one gene, then her risk is half of mine, so, if her gene wasn't 'triggered', then she didn't have another one to possibly be triggered. Does that make sense?? That's my theory anyway.

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Thanks everyone...

this is all so interesting...the genes are so hard to understand...

Now that I have learned a few things about genes I am looking at my family history with more scrutiny...

My mom almost died as kid and had to live on rice gruel and bananas for years...

(Celiac or what they used to call sprue?????...that, in those days they thought kids would outgrow? Who knows?)

My mom died of a very early Alzhiemers...She got sick in her early fifties ...I lost her way too soon!

Her sister and my maternal Aunt...never had children because she miscarried all of them...died of an unknown Muscular Dystrophy type illness...they never figured out what it was...

She died at only 42 years of age

My sister Positive for Celiac...ttg's by bloodwork in the 100's, Positive Endoscope, Severe Osteoporosis, and vitamin deficiencies.

No wonder that having this gene sequence would worry me....I want to know all I can....

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Thanks everyone...

this is all so interesting...the genes are so hard to understand...

Now that I have learned a few things about genes I am looking at my family history with more scrutiny...

My mom almost died as kid and had to live on rice gruiel and bananas for years...

(Celiac or what they used to call sprue?????...that, in those days they thought kids would outgrow? Who knows?)

My mom died of a very early Alzhiemers...She got sick in her early fifties ...I lost her way too soon!

Her sister and my maternal Aunt...never had children because she miscarried all of them...died of an unknown Muscular Dystrophy type illness...they never figured out what it was...

She died at only 42 years of age

My sister Positive for Celiac...ttg's by bloodwork in the 100's, Positive Endoscope, Severe Osteoporosis, and vitamin deficiencies.

No wonder that having this gene sequence would worry me....I want to know all I can....

Hi homemaker,

Just though I might chime in too. I'm sorry about your losing your mother so early. There is some research showing links between some forms of Alzhiemers and celiac disease. Also untreated celiac disease carries a higher risk of infertility, and other reproductive issues, spinabifida, neuro-degeneratve diseases and a whole host of CNS conditions as well. There is a book called 'Recognizing Celiac Disease' which lists over 300 associated disorders, diseases, and conditions. You might be interested in it. What it is especially useful for (for me) is helping to identify and link specific nutrient deficiencies with specific symptoms. A number of my symptoms and conditions had the same nutritional malabsorption issues as their root.

I'm DQ8+DQ3. My Dad is double DQ8 so my mom carries at least DQ3 but she has never had the gene testing done.

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I know that you only need to have one copy of HLA-DQ02 or 08 to develop celiac disease. I do not know if having two copies makes you more likely to develop celiac disease. I am DQ-02 & DQ-08 positive but do not have celiac disease at this time. I know that I may develop it later in life so I pay attention to my body and get serological testing done periodically. My son, which definitely has at least one copy of DQ 02 and/or DQ-08 does have celiac disease. It's clear that the entire celiac mechanism is not fully understood. It is such a wildly complex disease.

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Whoops ...just noticed my spelling in my forum title...I mean two copies! :rolleyes:

Does anyone have any links about the increased risk of Celiac Disease with someone like my self having 2 copies of HLA_DQ2?

Does anyone else out there have 2 copies of HLA-DQ 2?

HLA-DQB1 Molecular Analysis, Allele 1: 0201

HLA-DQB1 Molecular Analysis, Allele 2: 0202

Serologic equivalent: HLA-DQ 2,2 (Subtype 2,2)

The report said something like...by having the 0202 gluten sensitivity gene along with the 0201 Celiac Gene...my risk is greater and the possibility is more severe disease...

I was looking for more information regarding this connection...

Thanks

I am also a double DQ-2 and what that means is both of your parents carry the gene for Celiac....you inherit one from each parent. Celiac Disease is on both ides of your family, like mine. Not too hard to grasp considering my father is Irish/English and my mother is Scottish/English. It also signifies that your chances of triggering is greater with 2 copies and if you do trigger, the disease will be more severe. That is exactly what happened to me. I was withering away to nothing by the time it was diagnosed. :o This is actually good information to have as it backs up any diagnosis a doctor would be making.

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QUOTE...."I am also a double DQ-2 and what that means is both of your parents carry the gene for Celiac....you inherit one from each parent. Celiac Disease is on both ides of your family, like mine. Not too hard to grasp considering my father is Irish/English and my mother is Scottish/English. It also signifies that your chances of triggering is greater with 2 copies and if you do trigger, the disease will be more severe. That is exactly what happened to me. I was withering away to nothing by the time it was diagnosed. ohmy.gif This is actually good information to have as it backs up any diagnosis a doctor would be making."

Thank you...I without a doubt believe it is on both sides of my family ....

I am Scottish Gaelic and Swedish and a bit of old yankee English thrown in for good measure! :P

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