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IMResident

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Celiac.com - Celiac Disease & Gluten-Free Diet Support Since 1995

Everything posted by IMResident

  1. IMResident
    Katherine, here's an article on tolerance which can be induced by ingestion of an antigen (this one pertains to the treatment of Multiple Sclerosis): Treatment of autoimmune disease by oral tolerance to autoantigens. Whitacre CC, Gienapp IE, Meyer A, Cox KL, Javed N. Department of Medical Microbiology and Immunology, Ohio State University College...
  2. IMResident
    GFP, obviously I was kidding when I said that I am 100% croatian. I am sorry you found it disturbing. I however disagree with your opinion that most countries in Europe have a predominantly mixed heritage. That would be the case in the US as most people have parents of 2 or more different ancestries.
  3. IMResident
    Wow, some people seem to be really overreacting. This is not dangerous medical advice. Going on gluten again is common in blood test positive celiacs for the gluten challange for 6 months or more without any adverse long term effects. I said she should TRY it for 2 weeks. No harm in that. Believe me this is NOT like insulin, and it's not going to kill her...
  4. IMResident
    Ursula, it sounds like the gluten free diet is causing a lot of conflict with your family, and you mentioned that you are back to where you started from with regards to seeing improvement after going gluten free. Here's what I would do in your situation: I would first evaluate how you feel now and how you felt a year ago before you started the diet, including...
  5. IMResident
    >Define "improve significantly"? >Certainly a large percentage of patients taking psyhctropics change significantly but that doesn't mean >they improve. They probably certainly complain less and are probably less assertive with their GP but that >doesn't mean they have "improved significantly". Improve significantly means a 50% or more...
  6. IMResident
    >The numbers indicate otherwise, the numbers point more towards therapy alone or therapy AND drugs, >but not therapy OR drugs. Drugs only cover up a symptom. Without finding the cause you are just asking >for trouble. That cause could be chemical or could be phychological or both. I think this is something we can both agree on. Therapy and drugs...
  7. IMResident
    You don't need lab tests to diagnose depression because it's not a disease caused by physical factors. OR I should rather say it's caused by both a combination of neurochemical and psychological factors. The psychological part of depression is just as important and many times depression is just caused by psychological factors. For example most depressed...
  8. IMResident
    I don't know where you got that impression from but I am genuinly trying to help. There's a reason why I dislike enterolab so much. First, I want to tell my personal story because this might put things in perspective. So sorry but this is going to be a long post. I think you, or maybe someone else asked me what my personal interest in this board is and...
  9. IMResident
    Cara, what's your definition of gluten sensitivity? Because if you tested anybody in the normal population, close to 100% would have fecal and blood antibodies against gluten, as well as transglutaminase and anti-endomysial antibodies. In low numbers but they would have them nonetheless. People also have anti-rice, anti-potatoe, anti-vegetable, anti-everything...
  10. IMResident
    Actually antibodies levels decline pretty slowly (about 10% per month) so being gluten free for one or 2 months is not a problem and you can still be blood tested. All labs doing fecal antibody testing including Dr. Fine use exactly the same lab tecniques and prodcedures as in the study, so this study applies to his lab as well. To answer your second...
  11. IMResident
    I want to clarify what specificity of 58% means for the fecal antibody testing. In the case of the study there were 24 people with celiac and 60 controls (completely healthy people without any intestinal or gluten sensitivity symptoms). The fecal testing found about 22 of the celiac people positive for celiac as well as about 20 of the completely healthy...
  12. IMResident
    I agree with this 100% except for the fecal tests. I read the studies you mentioned. The first study supports the theoritical role for fecal secretory IgA antigliadin testing but contradicts solely antigliadin IgA testing (because of overlap between those with celiac and controls hence low specificity). The second study supports the use of the antiendomysial...
  13. IMResident
    Matilda, I would like to respond to a couple of things, first of all according to the study fecal anti-gliadin/transglutaminase testing has a sensitivity in the 90s and a specificity of something like 50%, but the problem is high sensitivity in a test is useless without high specificty. It would be a completely useless screening test, despite what Dr...
  14. IMResident
    I beg to differ, all my grandparents and great-grandparents on both my fathers and mothers side for 100% croatian, with maybe a little Hungarian contamination. I am not sure about what those haplotypes mean, but I am sure I have the 100% Croatian haplotype. I think celiac is a lot less common in Croatian and Eastern European populations because all we...
  15. IMResident
    Most people here seem to be Irish/Swedish/German. I am 100% pure blooded Croatian .... are there any other Eastern Euros/Slavic people out there with celiac disease?
  16. IMResident
    My mother and my brother both have celiac disease and I have the genes for it, so sooner or later I might have it.
  17. IMResident
    It is my understanding that many people use enterolab for their celiac testing. I was wondering why people here don't use traditional testing laboratories, such as the ones that test for blood anti-endomysial/transglutaminase/antigliadin antibodies for diagnosis of celiac/gluten sensitivity, because these are as far as I know highly specific and highly sensitive...
  18. IMResident
    The memory B cells and memory T cells live for 30-40 years sometimes even life , so once you're exposed to something it's very hard to lose the immune response to it. The problem with tetanus is that the vaccine is an immunoglobulin which binds with the tetanus toxin, and inactivates it and these immunoglobulins decay over time. It's a form of "passive"...
  19. IMResident
    Hm, my previous post seems to have been deleted so I'll reply to this. The trigger for celiac disease is thought to be infection with the adeno virus. It is found in the intestines of many people and its protein coat is simillar to gliadin. Here's an excerpt from a study: >A 12 amino acid sequence from the adenovirus 12 E1B protein is homologous...
  20. IMResident
    GFP, well if you're interested, it's been a while since I've taken immunology but this is the way I remeber: HLA genes, especially Dp/Dq/Dr code for molecules called "MHC class II molecules" which is the protein on the cells called "antigen presenting cells" that present foreign antigens to Th lymphocyte. For example let's say you have a bacteria in...
  21. IMResident
    Hey Mike, here's a kink: Open Original Shared Link, although it uses many technical terms.
  22. IMResident
    I tried to put it in very simple terms. It's obviously a lot more complicated than a simple mutation, because autoimmune diseases are caused by multiple factors, but the presence of abnormal HLA genes is the most important.
  23. IMResident
    I personally don't think there's sufficent evidence for the leaky gut hypothesis causing other autoimmune diseases for 2 reasons. First if you have foreign proteins entering the body than they would first go by the portal vein to the liver. The portal vein is the only vein that drains the intestines. The function of the liver is to detoxify any foreign...
  24. IMResident
    I disagree wholeheartedly with this. I think most of medicine is based on research, either past or current that is being updated all the time. 2 areas which have especially progressed at a rapid rate over the past 5-10 years are genetics and immunology. However you can't just accept all research at face value. I think even most researchers agree that some...
  25. IMResident
    I think stress reduction, excercise and lifestyle modifiction would be helpful. In other words everything Dr. Lam said with the exception of cortisol and licourice tea which would not only not help but could actually be dangerous.
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