Butcher's Broom is a great, natural way to relieve RLS. I've used it as needed for years. It takes a little while to kick in, but once it does, legs are back to normal. I've never noticed any side effects, but make sure there's no gluten in the capsules. I don't think my RLS is related to celiac, but it's annoying, whatever the cause (I've heard of lots of potential causes, but no one seems to be sure - although anything that helps improve circulation seems to help, according to what I've read). I like the Butcher's Broom because it's so mild, so I don't feel like I'm potentially creating more problems with my solution (as I do with prescription drugs for anything). It doesn't get to the source of the problem, but it helps get rid of it for the night. Good luck.