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davemu

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  1. davemu
    I dont have classical symptoms but I wonder if it warrants further investigations... The one thing I notice when trying gluten-free is that the reflux symptoms improve, my incredible thirst goes away, and my appetite normalizes without the frequent hunger pangs. It is frustrating to be thorough in investigating ones health without coming off sounding like...
  2. davemu
    Thank you gottaski. Very useful info. Other than family history my ferritin is borderline for a male that eats exceptionally well (ferritin of 50 - what's a "normal" ferritin is another discussion. I think folate and liver enzymes were normal. I have issues with sleep, anxiety, chronic nasal congestion and recurrent chest colds. Im pale but not anemic - in...
  3. davemu
    Troy you will find my "ultimate goal" stated in one of my first posts, if you only cared to read it. I wanted to know where you got the value of 70% sensitivity for the ttg blood test. I also clearly stated it was of personal interest because I too had a negative ttg and wanted to know how reliable this result is. Unfortunately you became too pre-occupied...
  4. davemu
    ... And someone has yet to post one single piece of literature that speaks to this "extraordinary, mounting evidence". I don't know why my asking is just falling on deaf ears. I'm not vehemently arguing anything, if you cared to read my previous posts you would know that I just want to know where you guys are getting your numbers from. It seems like the source...
  5. davemu
    Systematic review: the use of serology to exclude or diagnose coeliac disease (a comparison of the endomysial and tissue transglutaminase antibody tests). Authors Lewis NR, Scott BB. ---------- Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease. Authors Lewis...
  6. davemu
    I actually merely corrected some misunderstanding on your end. It seems you didn't handle that too well. I never questioned the diagnosis, I only asked for the source of your information (to which you gave me a smart ass reply about using google and then gave me a misguided lesson on blood tests). The purpose of this board is to educate each other, is...
  7. davemu
    With that line of reasoning we would be doing joint fluid sampling for diagnosing rheumatoid arthritis or performing heart biopsies to diagnose heart attacks. Enzymes and antibodies are present in the bloodstream. Let's agree to disagree because you have a high almighty attitude about when it comes to your understanding of things.
  8. davemu
    Yeah I definitely agree with your points of view. I'm going to get it investigated further. As for the sensitivity thing, it seems you have it backwards. A high sensitivity means that you are going to catch most people with the disease. 99% sensivity means that you are only going to miss 1% of the diagnoses (in the form of a false negative). In other...
  9. davemu
    See I'm just wondering about a credible source. The most up to date medical literature indicates high sensitivity of ttg. This means that false negatives occur 1-5% of the time. This means that a negative result is accurate 95-99% of the time. There are many ways to slice it. The test is supposed to be highly sensitive and highly specific meaning that either...
  10. davemu
    No reason for you to get snarky. Any reputable source I came across suggests the ttg has 95-99% sensitivity. The fact that antibodies predominate in the gut is irrelevant - If the test works, it works. If you have other information I am interested to find out where it's from, that's all. This is also for personal reasons as I am wondering whether I should...
  11. davemu
    Any chance your symptoms fit with those of dyshidrotic eczema and not true DH?
  12. davemu
    I am interested in your information about the sensitivity of the TTG test, as I too have a positive family history with negative bloodwork. My understanding was that a false negative was rare and hence the hesitancy of most doctors proceeding with an endoscopy in the setting of negative bloodwork. It is true that if you are IgA deficient the negative TTG...
  13. davemu
    I'm simply being objective here. The TTG should have a sensitivity of 95-99%, meaning there should only be a false negative of 1-5% of celiacs. This is why it's used as a screening test. If it was only 70% sensitive then it would make a horrible screening test. This stat may change with our evolving understanding of the disease. The only reason it's important...
  14. davemu
    This is good to know. Thank you. I am going by current medical literature, which as we know is ever changing. I do question the validity of diagnosing celiac based on 2/3 positive tests. That's an exceptionally unscientific way of making a diagnosis. I would be more inclined to look at your pre-test probability (the fact that immediate family history is...
  15. davemu
    The issue here is that they did a biopsy with a negative TTG. Usually one stops at a negative blood test unless one has convincing symptoms of celiac and/or a strong family history. This is why your doc is a bit unsure of how to interpret these results. That being said, in a otherwise healthy person with no recent gastrointestinal infection the pathology...
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