Test And Biopsy Questions

[Caeryn23]

I was tested for Total IgA and Tissue Transglutaminase AB IgG. Both are negative. Are those accurate for celiac?

My upper endoscopy biopsy came back negative. The GI who ordered the biopsy said if it is negative, I could still have celiac or gluten sensitivity/intolerance. He also said damage could be in other parts in the intestine. The GI who did the biopsy and the GI I saw for the follow-up said I can't have celiac because the biopsy was negative. Both also said damage can't be in other parts in the intestine. Which GI is correct? I saw 3 different doctors, because I go to a clinic.

I also have the HLA genes DQ2, DQ8, DR4, and DR7.

Thanks.

[Ursa Major]

The GI who said that you could still have celiac disease despite a negative blood test and biopsy is right. The blood tests aren't all that reliable, and he biopsy is hit and miss. They only take biopsies from the upper third of the small intestine, but the damage can be lower down than that.

Also, if your villi are still in the beginning stages of pathology, your blood work would be negative, and so would your biopsies be, despite having celiac disease.

You have the celiac disease genes, and you have the symptoms. It is very likely that you have it.

In your case, trying the gluten-free diet is the true and most valid test. If you improve on the gluten-free diet, you will have your answer.