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Positive Anti-gliadin Igg


hinoko

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hinoko Newbie

In November I had a celiac blood panel done. All of my results were negative except for my IgG results. My results were 69 where >10 was considered high. The doctor said that based on my symptoms, and such a high level of anti-gliadin antibodies that he was positive that I had Celiac, or at the very least, a severe gluten intolerance. With all of the controversy over IgG, I'm wondering if it's possible that something else was causing my symptoms, and my gluten free diet is only a band-aid fix.

Here's a quick overview of my symptoms: I began to have digestion problems when I turned 18 (and moved away to university). The next year I was diagnosed with ADHD and IBS. Two years later I moved to Italy for a semester and I had urgent and persistent diarrhea every day. I lost 20 lbs (while I lived in Italy I ate gluten for breakfast, lunch, and dinner - pasta, pizza, panini). When I returned home I gained a few pounds but continued to have diarrhea every day.

After graduating from college I moved to Japan and the diarrhea stopped. I thought I was cured. After Christmas I began to import some of my favorite American foods (flour tortillas and goldfish), and began to experience joint and muscle pain, as well as muscle spasms; I was given pain meds and muscle relaxers. Three months later I began to have stabbing pains under my ribs on the left side. I went to a dr and he believed that I had an ulcer from the NSAIDS and gave me meds.

The pain continued to get worse, not better (especially in the evening and after eating). The dr ran quite a few tests (CT scan, blood work, upper endoscopy, etc.) The only finding of any interest was a polyp in my esophagus (which I was told was benign). The pain was so bad that I could barely walk. They diagnosed me with stress. They don't give real pain meds (only ibuprofen) in Japan, so I was given an SNRI anti-depressant to deal with the pain. The pain didn't leave, but it was manageable (for the most part).

I returned home and went on a gluten free diet in November. I am able to eat eggs and dairy again, which my body couldn


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    • trents
      NCGS does not cause damage to the small bowel villi so, if indeed you were not skimping on gluten when you had the antibody blood testing done, it is likely you have celiac disease.
    • Scott Adams
      I will assume you did the gluten challenge properly and were eating a lot of gluten daily for 6-8 weeks before your test, but if not, that could be the issue. You can still have celiac disease with negative blood test results, although it's not as common:  Clinical and genetic profile of patients with seronegative coeliac disease: the natural history and response to gluten-free diet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606118/  Seronegative Celiac Disease - A Challenging Case: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441776/  Enteropathies with villous atrophy but negative coeliac serology in adults: current issues: https://pubmed.ncbi.nlm.nih.gov/34764141/  Approximately 10x more people have non-celiac gluten sensitivity than have celiac disease, but there isn’t yet a test for NCGS. If your symptoms go away on a gluten-free diet it would likely signal NCGS.
    • Xravith
      I'm very confused... My blood test came out negative, I checked all antibodies. I suppose my Total IgA levels are normal (132 mg/dl), so the test should be reliable. Still, I'm not relieved as I can't tolerate even a single biscuit. I need to talk to my doctor about whether a duodenal biopsy is necessary. But it is really possible to have intestinal damage despite having a seronegative results? I have really strong symptoms, and I don't want to keep skipping university lectures or being bedridden at home.
    • Scott Adams
      They may want to also eliminate other possible causes for your symptoms/issues and are doing additional tests.  Here is info about blood tests for celiac disease--if positive an endoscopy where biopsies of your intestinal villi are taken to confirm is the typical follow up.    
    • Scott Adams
      In the Europe the new protocol for making a celiac disease diagnosis in children is if their tTg-IgA (tissue transglutaminase IgA) levels are 10 times or above the positive level for celiac disease--and you are above that level. According to the latest research, if the blood test results are at certain high levels that range between 5-10 times the reference range for a positive celiac disease diagnosis, it may not be necessary to confirm the results using an endoscopy/biopsy: Blood Test Alone Can Diagnose Celiac Disease in Most Children and Adults TGA-IgA at or Above Five Times Normal Limit in Kids Indicates Celiac Disease in Nearly All Cases No More Biopsies to Diagnose Celiac Disease in Children! May I ask why you've had so many past tTg-IgA tests done, and many of them seem to have been done 3 times during short time intervals?    
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